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    v1.0.30
    OpenPayerBilling CodesLaparoscopic Procedures on the KidneyCPT cpt-50543-laparoscopic-partial-nephrectomy
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    CPT 50543: Laparoscopic Partial Nephrectomy

    Medicare pays $1352 on average nationally for this procedure.

    CPT code 50543 describes a surgical laparoscopic partial nephrectomy in which the provider removes part of a kidney using minimally invasive laparoscopy; the service is a surgical procedure typically performed in an operating room or ambulatory surgery center for treatment of localized renal masses or other focal renal pathology.

    For related coverage guidance, see recent payer policy updates: Surgical Procedures, Outpatient Surgical Procedures - Site of Service, Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in Adults.

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    Table of contents

    Progress1 / 7

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old man with a 3-cm enhancing mass in the mid-pole of the right kidney is referred for a nephron-sparing procedure. He has controlled hypertension and baseline creatinine of 1.1 mg/dL. After preoperative imaging with contrast CT and anesthesia assessment, the urologic surgeon schedules a laparoscopic partial nephrectomy using transperitoneal approach under general anesthesia. The clinical workflow includes preoperative informed consent, intraoperative laparoscopic tumor excision with renorrhaphy and hemostasis, possible intraoperative ultrasound localization, specimen retrieval in an endoscopic bag, and postoperative monitoring in a post-anesthesia care unit. Pathology is submitted for histologic diagnosis. Typical site of service is an outpatient ambulatory surgery center or hospital operating room depending on patient comorbidities and anticipated complexity. Payors commonly involved include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, BUCA, and Medicare.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    50545Laparoscopy, surgical; nephrectomy, complete, abdominal, including partial ureterectomy if performedAlternative when a radical or complete nephrectomy is required instead of partial; may be selected if tumor involves most of the kidney.
    50740Ureteral stent placement, cystoscopic; internal ureteral stent placementMay be performed before or after partial nephrectomy for ureteral drainage or to protect the ureter.
    76942Ultrasonic guidance for needle placement (e.g., for intraoperative ultrasound)Intraoperative ultrasound localization of the renal tumor to guide excision.
    49999Unlisted procedure, abdomen, peritoneum and omentumMay be used for atypical laparoscopic maneuvers not described by specific codes — documentation required.
    36415Collection of venous blood by venipuncturePreoperative laboratory testing commonly performed prior to 50543.

    Related Modifiers

    14 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Showing 1–10 of 14

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207L00000X
    208800000X
    207W00000X
    363A00000X
    261QE0800X
    1744R1102X
    174M00000X
    2080C0008X

    Related ICD-10-CM Codes

    29 rows

    ICD-10-CM CodeDescription
    C64.1Malignant neoplasm of right kidney, except renal pelvis
    C64.9Malignant neoplasm of unspecified kidney, except renal pelvis
    D63.1Anemia in chronic kidney disease
    N03.9Chronic nephritic syndrome with unspecified morphologic changes
    N04.9Nephrotic syndrome with unspecified morphologic changes
    N11.9Chronic tubulo-interstitial nephritis, unspecified
    N12Tubulo-interstitial nephritis, not specified as acute or chronic
    N13.2Hydronephrosis with renal and ureteral calculous obstruction
    N13.6Pyonephrosis
    N17.9Acute kidney failure, unspecified

    Showing 1–10 of 29

    Related Payer Policy Updates

    Specialty: General Surgery1 / 2

    10 rows

    PolicyPayerEffective Date
    Surgical ProceduresUnitedHealthcare2026-09-01
    Outpatient Surgical Procedures - Site of ServiceUnitedHealthcare2026-09-01
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01
    Medical Necessity Guidelines — Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Ambulatory Surgery Center (ASC) - Site of Care PolicyKaiser Permanente2026-08-01

    Related Codes

    CPT-50541-LAPAROSCOPIC-RENAL-CYST-ABLATION-CRYO-RFA

    CPT 50541: Laparoscopic Destruction of Renal Cysts

    CPT-50542-LAPAROSCOPIC-RENAL-MASS-ABLATION-CRYO-RADIOFREQUENCY

    CPT 50542: Laparoscopic Destruction of Renal Mass Lesion(s)

    CPT-50544-PYELOPLASTY-URETEROPELVIC-JUNCTION-REPAIR

    CPT 50544: Pyeloplasty to Repair Ureteropelvic Junction Obstruction

    CPT-50545-RADICAL-NEPHRECTOMY-KIDNEY-AND-SURROUNDING-STRUCTURES

    CPT 50545: Radical Nephrectomy Including Gerota's Fascia

    CPT-50546-LAPAROSCOPIC-NEPHRECTOMY-WITH-PARTIAL-URETERECTOMY

    CPT 50546: Laparoscopic Nephroureterectomy with Partial Ureter Removal

    CPT-50547-LAPAROSCOPIC-DONOR-NEPHRECTOMY-COLD-PRESERVATION

    CPT 50547: Laparoscopic Living Donor Nephrectomy

    CPT-50548-LAPAROSCOPIC-NEPHROURETERECTOMY-KIDNEY-AND-URETER-REMOVAL

    CPT 50548: Laparoscopic Nephroureterectomy

    CPT-50549-LAPAROSCOPIC-RENAL-UNLISTED-PROCEDURE

    CPT 50549: Laparoscopic Renal Procedure, Unlisted

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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