CPT code 50542 covers laparoscopic destruction of renal mass lesions using cryoablation or radiofrequency ablation. This procedure is a minimally invasive surgical option for targeted treatment of renal masses and is relevant nationally for surgical urology, oncology, and outpatient surgical centers. The code captures clinically significant interventions that can affect downstream imaging, follow-up care, and facility billing.

Key payers addressed include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise clinical description of the procedure, the typical sites of service, and the types of situations in which the code is used. The publication also summarizes common billing modifiers and related administrative considerations when available, and provides context for how the procedure fits into surgical oncology and interventional urology service lines.

This report is intended to inform revenue cycle teams, surgical program managers, and policy analysts about the clinical intent and billing context of CPT code 50542, outline what to expect in facility and professional billing workflows, and identify where further data or payer-specific policy reviews are typically required.