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CPT 49185: Percutaneous Chemical Destruction of Fluid Collection

CPT code 49185 defines a percutaneous, image-guided chemical destruction of fluid collections such as lymphoceles, cysts, or seromas. The provider performs the procedure through a small skin incision using ultrasound or fluoroscopic guidance; contrast material may be used for enhanced visualization. The procedure includes the diagnostic component plus radiological supervision and interpretation when performed, making it a radiology-led interventional service. Nationally, this code is relevant for interventional radiology, hospital outpatient departments, and ambulatory surgery centers given the frequency of postoperative seromas and symptomatic fluid collections.

Key payers addressed in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will gain a concise understanding of the clinical intent and typical sites of service for 49185, the payer landscape covered here, and what to expect in terms of where the procedure is billed and supervised. The publication also outlines benchmarking and policy context relevant to billing and coverage (benchmarks and detailed payer policy comparisons), plus clinical context that clarifies when this service is reported versus alternative drainage or excision procedures. Data not available in the input will be noted where applicable.

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Billing Code Overview

CPT code 49185 describes a percutaneous procedure for the chemical destruction of a fluid collection (for example, a lymphocele, cyst, or seroma) performed through a small skin incision under imaging guidance. The technique uses ultrasound or fluoroscopic guidance, and the clinician may inject contrast material to enhance visualization. The procedure includes the diagnostic study and radiological supervision and interpretation when those services are performed.

Service type: Image-guided percutaneous chemical ablation/drainage procedure

Typical site of service: Hospital outpatient setting, ambulatory surgery center, or interventional radiology suite

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CPT 49185: Percutaneous Chemical Destruction of Fluid Collection

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Get alerted when payer policies referencing 49185 are released or updated.

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Billing Code Overview

Service type: Image-guided percutaneous chemical ablation/drainage procedure

Typical site of service: Hospital outpatient setting, ambulatory surgery center, or interventional radiology suite

Clinical & Coding Specifications

Clinical Context

A 62-year-old male presents 3 weeks after open inguinal hernia repair with a progressively enlarging, fluctuant groin swelling, local tenderness, and low-grade fever. Ultrasound demonstrates a 5-cm fluid collection consistent with a seroma. The interventional radiologist is consulted and schedules a percutaneous, image-guided chemical ablation of the fluid collection using ultrasound guidance. In the procedure suite or outpatient interventional radiology (IR) unit, the patient is positioned and the skin prepped; local anesthetic is administered. Under real-time ultrasound (or fluoroscopic) guidance, a small skin puncture is made and a needle or catheter is advanced into the collection. Contrast may be injected to confirm location. A sclerosing agent is instilled to chemically obliterate the cavity; aspiration of fluid may be performed before or after instillation. The procedure includes diagnostic imaging, radiological supervision, and interpretation. Typical site of service is an outpatient interventional radiology suite, ambulatory surgery center, or hospital outpatient department. Typical clinical workflow includes preprocedure consent and coagulation review, image localization, needle/catheter placement, chemical instillation with monitoring, postprocedure ultrasound to confirm reduction, and brief recovery with discharge instructions and follow-up imaging or clinic visit.

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	When billing separately for the physician’s interpretation/performing professional portion when the facility bills technical component.
`59`	Distinct procedural service	When a separate and distinct percutaneous chemical destruction is performed on a different site or at a distinct session from other procedures on the same date.
`52`	Reduced services	When the procedure is partially reduced or not completed as described (e.g., attempted but limited by anatomy or patient intolerance).
`53`	Discontinued procedure	When the procedure is started but halted due to an adverse event or acute change in patient condition.
`76`	Repeat procedure by same physician	When the same physician repeats the procedure later the same day due to inadequate effect or recurrent collection.
`77`	Repeat procedure by another physician	When a different physician repeats the procedure same day.
`62`	Two surgeons	When two surgeons with different specialties are required and both perform a substantive portion of the procedure.
`78`	Unplanned return to the operating/procedure room for a related procedure during the postoperative period	When an unplanned percutaneous re-intervention is required during the global period.
`79`	Unrelated procedure or service by the same physician during the postoperative period	When the procedure is unrelated to a recent surgery and is performed during a global period for another surgery.
`50`	Bilateral procedure	If bilateral fluid collections are treated in the same session and payer requires a bilateral modifier.
`51`	Multiple procedures	When the chemical ablation is performed the same day as other reportable procedures and carrier requires multiple-procedure reporting.
`52`	Reduced services	(listed once above)
`QY`	Medical direction of one physician limited to 2–4 supporting personnel	When the physician provides medical direction for moderate sedation by ancillary staff during the procedure and the payer requires Q-code reporting.

Taxonomy Code	Specialty	Notes
207P00000X	Interventional Radiology	Primary specialty performing image-guided percutaneous procedures.
207K00000X	Diagnostic Radiology	Often performs and interprets image-guided procedures in hospital/ASC settings.
208C00000X	General Surgery	May perform percutaneous drainage or chemical ablation postoperatively, particularly for surgical-site collections.
363A00000X	Anesthesiology	Provides sedation or monitored anesthesia care when required during the procedure.
208000000X	Emergency Medicine	May perform or triage patients with symptomatic fluid collections in acute settings.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`I97.610`	Postprocedural seroma of abdominal wall	Seromas are a common indication for percutaneous chemical obliteration when persistent or symptomatic.
`I97.698`	Other postprocedural disorders of the genitourinary system, not elsewhere classified	Used when postoperative fluid collections occur in GU-related procedures where specific site codes are lacking.
`N28.9`	Disorder of kidney and ureter, unspecified	Retroperitoneal or perinephric fluid collections may require image-guided chemical ablation.
`K66.1`	Hemoperitoneum	Selected when loculated postoperative fluid collections in the peritoneal cavity are managed percutaneously.
`T81.4XXA`	Infection following a procedure, initial encounter	An infected fluid collection (abscess/seroma) may lead to percutaneous drainage and chemical destruction.
`L02.91`	Cutaneous abscess, unspecified site	Superficial collections approachable by percutaneous chemical ablation when appropriate.
`R22.2`	Localized swelling, mass and lump, trunk	Nonspecific code used when a localized postoperative fluid collection on the trunk is treated.
`M79.2`	Neuralgia and neuritis, unspecified	Included when adjacent nerve irritation from a fluid collection contributes to symptoms prompting intervention.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`49083`	Percutaneous drainage, abdomen and/or retroperitoneal abscess, percutaneous catheter placement with imaging guidance (e.g., abscess, seroma)	May be performed prior to or instead of chemical ablation for drainage and catheter placement; used when ongoing drainage is required.
`76942`	Ultrasonic guidance for needle placement (e.g., biopsy, aspiration, injection, localization device), imaging supervision and interpretation	Commonly billed in conjunction with percutaneous chemical destruction when ultrasound guidance is used for needle/catheter placement.
`77012`	Fluoroscopic guidance for therapeutic injection procedures (remote)	Used when fluoroscopic guidance is employed during needle/catheter placement or contrast injection to confirm positioning.
`49405`	Insertion of tunneled intraperitoneal catheter (e.g., peritoneal drainage)	Occasionally related when larger or tunneled drainage access is required for recurrent fluid collections before chemical ablation.
`96440`	Chemotherapy administration subcutaneous or intramuscular; injection or infusion of sclerosant agents when reported under specific payer rules (note: payer policy varies)	May be relevant when documentation and payer policy require coding for instillation of a sclerosant agent; clinical documentation must support appropriate use and billing.

CPT 49180: Percutaneous Abdominal Needle Biopsy

CPT-49186-OPEN-ABDOMINAL-EXCISION-DESTRUCTION-SMALL-TUMORS-CYSTS

CPT 49186: Open Excision/Destruction of Small Abdominal Tumors or Cysts

CPT-49187-OPEN-ABDOMINAL-TUMOR-CYST-EXCISION-5-1-10CM

CPT 49187: Open Abdominal Tumor or Cyst Excision, 5.1–10 cm

CPT-49188-OPEN-EXCISION-ABDOMINAL-TUMORS-10-1-20-CM

CPT 49188: Open Excision/Destruction of Abdominal Tumors or Cysts (10.1–20 cm)

CPT-49189-OPEN-ABDOMINAL-TUMOR-CYST-EXCISION-20-1-30CM

CPT 49189: Open Excision/Destruction of Abdominal Tumors or Cysts

CPT-49190-OPEN-ABDOMINAL-TUMOR-CYST-EXCISION-DESTRUCTION-OVER-30CM

CPT 49190: Open Excision/Destruction of Abdominal Tumors or Cysts, >30 cm

CPT-49215-SACROCOCCYGEAL-MASS-EXCISION

CPT 49215: Excision of Sacrococcygeal Mass

CPT-49250-UMBILICAL-EXCISION-HERNIA-INFECTION

CPT 49250: Excision of Umbilicus for Hernia or Nonhealing Infection

CPT-49255-OMENTECTOMY-FOR-METASTATIC-ABDOMINAL-PELVIC-CANCER

CPT 49255: Omentectomy for Metastatic Abdominal or Pelvic Cancer

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Modifier	Description	When to Use
`26`	Professional component	When billing separately for the physician’s interpretation/performing professional portion when the facility bills technical component.
`59`	Distinct procedural service	When a separate and distinct percutaneous chemical destruction is performed on a different site or at a distinct session from other procedures on the same date.
`52`	Reduced services	When the procedure is partially reduced or not completed as described (e.g., attempted but limited by anatomy or patient intolerance).
`53`	Discontinued procedure	When the procedure is started but halted due to an adverse event or acute change in patient condition.
`76`	Repeat procedure by same physician	When the same physician repeats the procedure later the same day due to inadequate effect or recurrent collection.
`77`	Repeat procedure by another physician	When a different physician repeats the procedure same day.
`62`	Two surgeons	When two surgeons with different specialties are required and both perform a substantive portion of the procedure.
`78`	Unplanned return to the operating/procedure room for a related procedure during the postoperative period	When an unplanned percutaneous re-intervention is required during the global period.
`79`	Unrelated procedure or service by the same physician during the postoperative period	When the procedure is unrelated to a recent surgery and is performed during a global period for another surgery.
`50`	Bilateral procedure	If bilateral fluid collections are treated in the same session and payer requires a bilateral modifier.
`51`	Multiple procedures	When the chemical ablation is performed the same day as other reportable procedures and carrier requires multiple-procedure reporting.
`52`	Reduced services	(listed once above)
`QY`	Medical direction of one physician limited to 2–4 supporting personnel	When the physician provides medical direction for moderate sedation by ancillary staff during the procedure and the payer requires Q-code reporting.

Taxonomy Code	Specialty	Notes
207P00000X	Interventional Radiology	Primary specialty performing image-guided percutaneous procedures.
207K00000X	Diagnostic Radiology	Often performs and interprets image-guided procedures in hospital/ASC settings.
208C00000X	General Surgery	May perform percutaneous drainage or chemical ablation postoperatively, particularly for surgical-site collections.
363A00000X	Anesthesiology	Provides sedation or monitored anesthesia care when required during the procedure.
208000000X	Emergency Medicine	May perform or triage patients with symptomatic fluid collections in acute settings.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`I97.610`	Postprocedural seroma of abdominal wall	Seromas are a common indication for percutaneous chemical obliteration when persistent or symptomatic.
`I97.698`	Other postprocedural disorders of the genitourinary system, not elsewhere classified	Used when postoperative fluid collections occur in GU-related procedures where specific site codes are lacking.
`N28.9`	Disorder of kidney and ureter, unspecified	Retroperitoneal or perinephric fluid collections may require image-guided chemical ablation.
`K66.1`	Hemoperitoneum	Selected when loculated postoperative fluid collections in the peritoneal cavity are managed percutaneously.
`T81.4XXA`	Infection following a procedure, initial encounter	An infected fluid collection (abscess/seroma) may lead to percutaneous drainage and chemical destruction.
`L02.91`	Cutaneous abscess, unspecified site	Superficial collections approachable by percutaneous chemical ablation when appropriate.
`R22.2`	Localized swelling, mass and lump, trunk	Nonspecific code used when a localized postoperative fluid collection on the trunk is treated.
`M79.2`	Neuralgia and neuritis, unspecified	Included when adjacent nerve irritation from a fluid collection contributes to symptoms prompting intervention.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`49083`	Percutaneous drainage, abdomen and/or retroperitoneal abscess, percutaneous catheter placement with imaging guidance (e.g., abscess, seroma)	May be performed prior to or instead of chemical ablation for drainage and catheter placement; used when ongoing drainage is required.
`76942`	Ultrasonic guidance for needle placement (e.g., biopsy, aspiration, injection, localization device), imaging supervision and interpretation	Commonly billed in conjunction with percutaneous chemical destruction when ultrasound guidance is used for needle/catheter placement.
`77012`	Fluoroscopic guidance for therapeutic injection procedures (remote)	Used when fluoroscopic guidance is employed during needle/catheter placement or contrast injection to confirm positioning.
`49405`	Insertion of tunneled intraperitoneal catheter (e.g., peritoneal drainage)	Occasionally related when larger or tunneled drainage access is required for recurrent fluid collections before chemical ablation.
`96440`	Chemotherapy administration subcutaneous or intramuscular; injection or infusion of sclerosant agents when reported under specific payer rules (note: payer policy varies)	May be relevant when documentation and payer policy require coding for instillation of a sclerosant agent; clinical documentation must support appropriate use and billing.

CPT 49180: Percutaneous Abdominal Needle Biopsy

CPT-49186-OPEN-ABDOMINAL-EXCISION-DESTRUCTION-SMALL-TUMORS-CYSTS

CPT 49186: Open Excision/Destruction of Small Abdominal Tumors or Cysts

CPT-49187-OPEN-ABDOMINAL-TUMOR-CYST-EXCISION-5-1-10CM

CPT 49187: Open Abdominal Tumor or Cyst Excision, 5.1–10 cm

CPT-49188-OPEN-EXCISION-ABDOMINAL-TUMORS-10-1-20-CM

CPT 49188: Open Excision/Destruction of Abdominal Tumors or Cysts (10.1–20 cm)

CPT-49189-OPEN-ABDOMINAL-TUMOR-CYST-EXCISION-20-1-30CM

CPT 49189: Open Excision/Destruction of Abdominal Tumors or Cysts

CPT-49190-OPEN-ABDOMINAL-TUMOR-CYST-EXCISION-DESTRUCTION-OVER-30CM

CPT 49190: Open Excision/Destruction of Abdominal Tumors or Cysts, >30 cm

CPT-49215-SACROCOCCYGEAL-MASS-EXCISION

CPT 49215: Excision of Sacrococcygeal Mass

CPT-49250-UMBILICAL-EXCISION-HERNIA-INFECTION

CPT 49250: Excision of Umbilicus for Hernia or Nonhealing Infection

CPT-49255-OMENTECTOMY-FOR-METASTATIC-ABDOMINAL-PELVIC-CANCER

CPT 49255: Omentectomy for Metastatic Abdominal or Pelvic Cancer

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Jul 29, 2026.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Jul 29, 2026.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

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CPT 49185: Percutaneous Chemical Destruction of Fluid Collection

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Billing Code Overview

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CPT 49185: Percutaneous Chemical Destruction of Fluid Collection

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Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Coding Specifications

Related Diagnoses

Related CPT Codes

Related Codes

References