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    v1.0.30
    OpenPayerBilling CodesRepair Procedures on the PancreasCPT cpt-48500-pancreatic-cyst-marsupialization
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    CPT 48500: Marsupialization of Pancreatic Cyst

    Medicare pays $1102 on average nationally for this procedure.

    CPT code 48500 describes an open surgical marsupialization of a pancreatic cyst, a procedure in which the surgeon incises the cyst and leaves it partially open to form a pouch; this represents an operative pancreatic cyst drainage technique typically performed as an open abdominal surgical procedure in an inpatient or operating room setting under general anesthesia and is billed as a discrete surgical service.

    For related coverage guidance, see recent payer policy updates: Surgical Procedures, Outpatient Surgical Procedures - Site of Service, Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in Adults.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 45–70-year-old adult presenting with abdominal pain, early satiety, or a palpable epigastric mass with imaging demonstrating a symptomatic pancreatic pseudocyst or true pancreatic cyst that communicates poorly with the pancreatic duct. The workflow begins with clinical evaluation, laboratory studies (CBC, CMP, amylase/lipase), and cross-sectional imaging (CT or MRI) confirming a cystic pancreatic lesion. Interventional planning includes assessment of cyst size, location relative to stomach or bowel, presence of infection or hemorrhage, and ductal anatomy.

    In the operating room or interventional suite under general anesthesia, the surgeon or advanced endoscopist performs a pancreatic cyst marsupialization (48500) by incising the cyst wall and creating a dependent opening to allow continuous drainage into the peritoneal cavity or adjacent hollow viscus, as appropriate. Intraoperative steps commonly include exposure of the pancreas, controlled cyst entry, evacuation of cyst contents, sampling for cytology and cultures, hemostasis, and partial opening and suturing of cyst edges to establish a pouch. Postoperative care includes monitoring for hemorrhage, fistula, infection, and appropriate imaging or follow-up drainage. Typical sites of service are inpatient operating room, ambulatory surgery center, or specialized endoscopy/interventional radiology suite depending on approach and patient acuity.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    47562Laparoscopic pancreatic cyst drainage, with or without cyst debridementMinimally invasive alternative to open 48500; may be performed instead of or prior to open marsupialization.

    48150 | Excision or destruction of lesion of pancreas, partial pancreatectomy | Used when definitive resection is required rather than drainage/marsupialization for neoplastic cysts.

    49083 | Unlisted laparoscopy procedure, abdomen, peritoneum and omentum | Sometimes used for novel or combined laparoscopic approaches to pancreatic cysts when no specific code applies.

    47530 | Laparoscopy, surgical; pancreatic necrosectomy | Performed when necrosis or infected pancreatic collections coexist and more extensive debridement is required.

    76700 | Ultrasound, abdominal, real time with image documentation | Preoperative or intraoperative imaging to localize cyst and guide drainage; typically performed prior to or during intervention.

    76937 | Ultrasound guidance for drainage procedures | Used when real-time ultrasound guidance assists cyst access for drainage or catheter placement related to 48500.

    Related Modifiers

    14 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Showing 1–10 of 14

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207L00000X
    207LP2900X
    207RP1001X
    2084P0800X
    163WD0400X
    2471B0102X
    315D00000X
    261Q00000X

    Related Payer Policy Updates

    Specialty: General Surgery1 / 3

    10 rows

    PolicyPayerEffective Date
    Surgical ProceduresUnitedHealthcare2026-09-01
    Outpatient Surgical Procedures - Site of ServiceUnitedHealthcare2026-09-01
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01
    Medical Necessity Guidelines — Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Ambulatory Surgery Center (ASC) - Site of Care PolicyKaiser Permanente2026-08-01

    Related Codes

    CPT-48510-OPEN-DRAINAGE-PANCREATIC-PSEUDOCYST

    CPT 48510: Open Drainage of Pancreatic Pseudocyst

    CPT-48520-PANCREATIC-CYST-ENTERIC-DRAINAGE

    CPT 48520: Pancreatic Cyst–Enteric Internal Drainage

    CPT-48540-PANCREATIC-CYST-INTERNAL-DRAINAGE-CYSTENTEROSTOMY

    CPT 48540: Pancreatic Cyst-Jejunostomy for Internal Drainage

    CPT-48545-PANCREAS-REPAIR-RECONSTRUCTION-TRAUMA

    CPT 48545: Repair and Reconstruction of Pancreas After Trauma

    CPT-48547-GASTRIC-TO-JEJUNUM-BYPASS-TRAUMATIC-ABDOMINAL-INJURY

    CPT 48547: Gastrojejunostomy to Bypass Duodenum for Traumatic Pancreatic Injury

    CPT-48548-PANCREATIC-JEJUNOSTOMY-PANCREATIC-DRAINAGE

    CPT 48548: Pancreaticojejunostomy for Pancreatic Drainage

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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