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    v1.0.31
    OpenPayerBilling CodesEndoscopic Stomal ProceduresCPT cpt-44404-colonoscopy-via-colostomy-with-submucosal-injection
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    CPT 44404: Colonoscopy via Colostomy Stoma with Submucosal Injection

    Medicare pays $484 on average nationally for this procedure.

    CPT code 44404 describes insertion of an endoscope to perform a colonoscopic examination through a colostomy stoma with one or more injections into the submucosa; service type: endoscopic therapeutic procedure (colonoscopy via colostomy) performed in an ambulatory surgical center, endoscopy suite, or hospital procedural area as appropriate for stoma access and therapeutic intervention.

    For related coverage guidance, see recent payer policy updates: Diabetic Supplies, Radiofrequency Ablation for Thyroid Nodules, Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Idaho Only).

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old male with a longstanding end colostomy presents for surveillance of peristomal mucosa after prior polypectomy via the stoma. The patient reports intermittent bleeding from the stoma and a recent change in stool output. The colorectal surgeon schedules an outpatient procedure to insert a flexible endoscope through the colostomy stoma to evaluate the colon segment accessible via the stoma and to perform targeted submucosal injections for lesion lifting prior to endoscopic resection.

    The clinical workflow includes pre-procedure consent and history, review of anticoagulation status, and stoma inspection. The patient is brought to an endoscopy suite or ambulatory surgical center, monitored per standard sedation protocols (moderate sedation or anesthesia as indicated). The provider inserts the endoscope through the colostomy stoma, identifies lesions, and performs one or more submucosal injections into the lesion base (saline, diluted epinephrine, or lifting solution) to raise the mucosa for safer biopsy or endoscopic mucosal resection. Hemostasis is achieved as needed. Post-procedure recovery occurs in the recovery area with discharge instructions focused on stoma care, signs of bleeding or perforation, and follow-up arranged with the colorectal clinic.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    45378Colonoscopy, flexible, proximal to splenic flexure; diagnostic, with or without collection of specimen(s) by brushing or washingSimilar diagnostic colonoscopy via the rectum; conceptually related as the standard colonic evaluation performed via the native route rather than a stoma.
    45380Colonoscopy with biopsy, single or multipleOften performed in conjunction when mucosal biopsies are needed in addition to submucosal injection and lesion removal via the stoma.
    45385Colonoscopy with removal of tumor(s), polyp(s), or other lesion(s) by snare techniqueFrequently follows submucosal injection (lifting) to facilitate safe snare polypectomy or endoscopic mucosal resection through a stoma.
    45390Colonoscopy with submucosal injection (for lesion lifting) when performed during colonoscopyRelated therapeutic maneuver; used in similar contexts when injections are done to lift lesions for resection (note: 44404 specifically describes injection through colostomy stoma).
    45382Colonoscopy with control of bleeding, any methodMay be performed during the same session if active bleeding is identified at the stoma or within the accessible colon segment.

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208600000X
    207T00000X
    208000000X
    363L00000X
    372500000X
    2279P1006X
    222Q00000X
    261QA3000X

    Related Payer Policy Updates

    Specialty: Endocrinology1 / 3

    10 rows

    PolicyPayerEffective Date
    Diabetic SuppliesCigna2026-10-15
    Radiofrequency Ablation for Thyroid NodulesCigna2026-10-15
    Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Idaho Only)UnitedHealthcare2026-10-01
    Continuous Glucose Monitoring and Insulin Delivery for Managing Diabetes (for Indiana Only)UnitedHealthcare2026-10-01
    Tzield (teplizumab-mzwv) CoverageUnitedHealthcare2026-10-01
    Medical Necessity Guidelines Insulin PumpsMass General Brigham Health Plan2026-10-01
    Medical Necessity Guidelines: Continuous Glucose MonitorsMass General Brigham Health Plan2026-10-01
    Continuous Glucose MonitoringAmbetter Nevada2026-10-01
    Salivary Hormone TestingOscar Health2026-10-01
    Bone Turnover Markers TestingOscar Health2026-10-01

    Related Codes

    CPT-44380-STOMAL-ILEOSCOPY-ENDOSCOPIC-ILEUM-EXAMINATION

    CPT 44380: Ileoscopy via Stoma with Brushings or Washings

    CPT-44381-ILEOSCOPY-THROUGH-STOMA-WITH-BALLOON-DILATION

    CPT 44381: Ileoscopy via Stoma with Endoscopic Balloon Dilation

    CPT-44382-ILEOSCOPY-THROUGH-STOMA-BIOPSY

    CPT 44382: Ileoscopy Through Stoma with Biopsy

    CPT-44384-ILEOSCOPY-WITH-STENT-PLACEMENT-THROUGH-STOMA

    CPT 44384: Ileoscopy with Endoscopic Stent Placement via Stoma

    CPT-44385-ILEAL-POUCH-ENDOSCOPIC-EVALUATION-WITH-BIOPSY-WASHINGS

    CPT 44385: Endoscopic Evaluation of Ileal Pouch with Brushings/Washings

    CPT-44386-ENDOSCOPIC-POUCHOSCOPY-WITH-BIOPSY

    CPT 44386: Endoscopic Examination of Ileal Pouch with Biopsy

    CPT-44388-COLONOSCOPY-VIA-COLOSTOMY-STOMA-SURVEILLANCE

    CPT 44388: Colonoscopy Through Colostomy Stoma for Evaluation

    CPT-44389-STOMAL-COLONOSCOPY-WITH-BIOPSY

    CPT 44389: Endoscopic Colon Examination Through Stoma with Biopsy

    CPT-44390-COLONOSCOPY-THROUGH-COLOSTOMY-STOMA-FOREIGN-BODY-REMOVAL

    CPT 44390: Colonoscopy via Colostomy for Foreign Body Removal

    CPT-44391-COLONOSCOPY-VIA-COLOSTOMY-STOMA-THERAPEUTIC-EVALUATION

    CPT 44391: Colonoscopy via Colostomy Stoma with Hemostasis

    Showing 1–10 of 19

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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