CPT code 43622 represents a total gastrectomy with construction of an esophagoduodenal pouch to preserve an uninterrupted alimentary tract, most commonly performed for gastric malignancy. As a high-acuity oncologic abdominal procedure, it has significant clinical, perioperative and reimbursement implications across hospital systems and payers nationally. Key payers commonly included in evaluations of this code are Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare and Medicare.

This publication provides a concise national overview of CPT code 43622, covering clinical context, typical site-of-service considerations, and the reimbursement and billing elements that influence hospital and surgeon workflows. Readers will find benchmarking information where available, common billing modifiers and claims considerations, and a summary of policy updates and coverage patterns that affect authorization, bundling, and post-acute care planning. The analysis is intended for hospital administrators, surgical departments, revenue cycle teams, and policy analysts seeking a practical reference on coding, coverage, and operational impacts for major upper gastrointestinal oncologic resections.