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    v1.0.30
    OpenPayerBilling CodesExcision Procedures on the StomachCPT cpt-43621-total-gastrectomy-small-bowel-anastomosis
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    CPT 43621: Total Gastrectomy with Small Bowel-to-Stomach Anastomosis

    Medicare pays $2102 on average nationally for this procedure.

    CPT code 43621 describes a total gastrectomy procedure involving surgical removal of the entire stomach with creation of an anastomosis between the distal small bowel and the esophagogastric region; the service is a major abdominal surgical procedure typically performed in an inpatient hospital operating room setting for definitive treatment of gastric disease or malignancy.

    For related coverage guidance, see recent payer policy updates: Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Esophagogastroduodenoscopy (EGD) Coverage Policy, Radiofrequency Therapy for Fecal Incontinence.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 62-year-old male with a long history of peptic ulcer disease and recurrent gastric outlet obstruction presents with intractable symptoms, weight loss, and failure of medical therapy. Diagnostic workup including endoscopy and computed tomography demonstrates a nonrepairable, diffusely diseased stomach (e.g., severe gastric scarring, pyloric stenosis, or multifocal malignancy not amenable to partial gastrectomy). The surgical team elects to perform a total gastrectomy with reconstruction by anastomosis of the distal divided small bowel to the esophagus or gastric remnant equivalent, consistent with 43621.

    Preoperative workflow includes surgical consultation, informed consent noting risks of total gastrectomy (bleeding, leak, nutritional consequences), optimization of comorbidities, nutritional assessment, and perioperative antibiotics. Intraoperative steps involve general anesthesia, abdominal exploration, mobilization and resection of the stomach, division of the proximal small bowel, creation of an appropriate alimentary limb, and anastomosis of the distal divided small bowel to the proximal alimentary tract. Postoperative care includes ICU or step-down monitoring as indicated, pain control, gradual advancement of diet with enteral support as needed, nutritional counseling, and surveillance for surgical complications.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    43631Excision of stomach, total; with reconstruction (e.g., Roux-en-Y)Alternative code for total gastrectomy with a specified reconstruction technique; may be used instead of 43621 depending on operative details.
    43280Esophagogastroduodenoscopy, diagnostic, with or without collection of specimen(s) by brushing or washingCommon preoperative diagnostic procedure to evaluate proximal gastric or esophageal involvement prior to 43621.
    44360Anastomosis, small intestine; single layer, hand-sewnMay be used to report enteric anastomosis technique when a distinct code is appropriate alongside 43621 if payer guidance allows.
    44970Enterolysis (lysis of intestinal adhesions), single or multipleOften performed intraoperatively if significant adhesions are encountered during exposure for 43621.
    49505Repair initial inguinal hernia, age 5 years or older; reducibleData not available in the input.

    Related Modifiers

    13 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…

    Showing 1–10 of 13

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208800000X
    207R00000X
    2081P0004X
    261QM2500X
    225800000X
    101YP2500X
    2251G0304X
    207QA0505X

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01

    Related Codes

    CPT-43605-OPEN-BIOPSY-EXCISION-GASTRIC-LESION

    CPT 43605: Open Biopsy and Excision of Gastric Lesion

    CPT-43610-GASTRIC-EXPLORATION-LESION-EXCISION

    CPT 43610: Exploration of Stomach and Excision of Lesion

    CPT-43611-GASTRIC-TUMOR-EXCISION-SURGICAL-ONCOLOGY

    CPT 43611: Excision of Cancerous Tumor of the Stomach

    CPT-43620-ESOPHAGOENTEROSTOMY-AFTER-GASTRECTOMY

    CPT 43620: Esophagojejunostomy After Gastrectomy

    CPT-43622-TOTAL-GASTRECTOMY-ESOPHAGODUODENAL-POUCH-RECONSTRUCTION

    CPT 43622: Total Gastrectomy with Esophagoduodenostomy

    CPT-43631-PARTIAL-GASTRECTOMY-GASTRODUODENOSTOMY

    CPT 43631: Partial Gastrectomy with Gastroduodenostomy (Billroth I)

    CPT-43632-PARTIAL-GASTRECTOMY-WITH-GASTROJEJUNOSTOMY

    CPT 43632: Partial Gastrectomy with Gastrojejunostomy

    CPT-43633-PARTIAL-GASTRECTOMY-STOMACH-RESECTION-RECONSTRUCTION

    CPT 43633: Distal Gastrectomy with Gastrojejunostomy

    CPT-43634-PARTIAL-GASTRECTOMY-WITH-INTESTINAL-POUCH-RECONSTRUCTION

    CPT 43634: Distal Gastrectomy with Intestinal Pouch Creation

    CPT-43635-GASTRIC-RESECTION-WITH-VAGOTOMY

    CPT 43635: Vagotomy with Distal Gastrectomy

    Showing 1–10 of 12

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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