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    v1.0.30
    OpenPayerBilling CodesExcision Procedures on the StomachCPT cpt-43605-open-biopsy-excision-gastric-lesion
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    CPT 43605: Open Biopsy and Excision of Gastric Lesion

    Medicare pays $807 on average nationally for this procedure.

    CPT code 43605 describes an open surgical biopsy with excision of part or all of a suspicious gastric lesion to establish diagnosis and determine malignant versus benign pathology; service type: open surgical biopsy/excisional procedure; typical site of service: inpatient or outpatient hospital operating room or surgical suite where open abdominal procedures are performed.

    For related coverage guidance, see recent payer policy updates: Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Esophagogastroduodenoscopy (EGD) Coverage Policy, Radiofrequency Therapy for Fecal Incontinence.

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    Clinical & Coding Specifications

    Clinical Context

    A 62-year-old patient presents with persistent upper abdominal pain and unintentional weight loss. Endoscopic evaluation identifies a suspicious gastric mass not amenable to complete endoscopic removal. After multidisciplinary review, the surgeon schedules an open surgical biopsy with excision of part of the lesion to establish histopathologic diagnosis and rule out malignancy. The perioperative workflow includes preoperative imaging (CT abdomen), informed consent documenting diagnostic intent, standard pre-op labs, general anesthesia, open laparotomy or limited incision to access the stomach, excisional biopsy of the lesion with hemostasis, specimen submission to pathology, and postoperative monitoring for bleeding, infection, and return of bowel function. Typical site of service is an inpatient or ambulatory hospital operating room. The service type is an open surgical diagnostic/excisional procedure of the stomach to determine lesion origin (benign versus malignant).

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    43239Esophagogastroduodenoscopy, flexible, transoral; with biopsy, single or multipleOften performed before open biopsy for endoscopic assessment and tissue sampling; may precede open excisional biopsy when endoscopic sampling is inadequate.
    49080Exploratory laparotomy, exploratory celiotomy with biopsy(s) of intra-abdominal organs (separate procedure)Related intra-abdominal exploratory approaches can be used when broader abdominal exploration is required in conjunction with gastric biopsy.
    88305Pathology examination, surgical pathology, intermediate complexity (e.g., gross and microscopic examination)Typical pathology CPT code for histologic examination of gastric biopsy specimens sent by the surgeon.
    99223Initial hospital care, typically 70 minutes or morePreoperative or immediate postoperative inpatient evaluation and management associated with major surgery.
    47562Laparoscopy, surgical, gastric procedures (example), when performedMinimally invasive gastric procedures may be performed instead of open biopsy when feasible; included for workflow context.

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207L00000X
    208000000X
    2086S0105X
    207RR0500X
    163WI0500X
    163WG0000X
    364SE0003X
    207WX0110X

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01

    Related Codes

    CPT-43610-GASTRIC-EXPLORATION-LESION-EXCISION

    CPT 43610: Exploration of Stomach and Excision of Lesion

    CPT-43611-GASTRIC-TUMOR-EXCISION-SURGICAL-ONCOLOGY

    CPT 43611: Excision of Cancerous Tumor of the Stomach

    CPT-43620-ESOPHAGOENTEROSTOMY-AFTER-GASTRECTOMY

    CPT 43620: Esophagojejunostomy After Gastrectomy

    CPT-43621-TOTAL-GASTRECTOMY-SMALL-BOWEL-ANASTOMOSIS

    CPT 43621: Total Gastrectomy with Small Bowel-to-Stomach Anastomosis

    CPT-43622-TOTAL-GASTRECTOMY-ESOPHAGODUODENAL-POUCH-RECONSTRUCTION

    CPT 43622: Total Gastrectomy with Esophagoduodenostomy

    CPT-43631-PARTIAL-GASTRECTOMY-GASTRODUODENOSTOMY

    CPT 43631: Partial Gastrectomy with Gastroduodenostomy (Billroth I)

    CPT-43632-PARTIAL-GASTRECTOMY-WITH-GASTROJEJUNOSTOMY

    CPT 43632: Partial Gastrectomy with Gastrojejunostomy

    CPT-43633-PARTIAL-GASTRECTOMY-STOMACH-RESECTION-RECONSTRUCTION

    CPT 43633: Distal Gastrectomy with Gastrojejunostomy

    CPT-43634-PARTIAL-GASTRECTOMY-WITH-INTESTINAL-POUCH-RECONSTRUCTION

    CPT 43634: Distal Gastrectomy with Intestinal Pouch Creation

    CPT-43635-GASTRIC-RESECTION-WITH-VAGOTOMY

    CPT 43635: Vagotomy with Distal Gastrectomy

    Showing 1–10 of 12

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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