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    v1.0.30
    OpenPayerBilling CodesExcision Procedures on the EsophagusCPT cpt-43122-partial-esophagectomy-esophagogastrostomy
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    CPT 43122: Partial Esophagectomy with Esophagogastric Anastomosis

    Medicare pays $2348 on average nationally for this procedure.

    CPT code 43122 describes a partial esophagectomy where the surgeon removes part of the esophagus (and may remove the upper stomach), connects the remaining esophagus to the remaining stomach, and may widen the gastric outlet; the service is a surgical resection of the esophagus typically performed as an inpatient major abdominal or combined thoracoabdominal operative procedure via an abdominal incision or combined abdominal and chest approach.

    For related coverage guidance, see recent payer policy updates: Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Esophagogastroduodenoscopy (EGD) Coverage Policy, Radiofrequency Therapy for Fecal Incontinence.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 62-year-old with progressive dysphagia, weight loss, and odynophagia who is diagnosed with a localized distal esophageal adenocarcinoma or high-grade Barrett-related stricture refractory to endoscopic therapy. After staging with endoscopic ultrasound and CT/PET to confirm resectable disease and assess for metastasis, the surgical team schedules an esophagectomy. The operation commonly performed under CPT 43122 involves transthoracic or transabdominal mobilization with resection of the affected esophageal segment and possible partial gastrectomy, followed by an esophagogastric anastomosis. Perioperative workflow includes preoperative optimization (cardiopulmonary evaluation, nutrition support), intraoperative monitoring (anesthesia, central access, arterial line), potential thoracic and abdominal incisions or a combined approach, and postoperative care in a monitored setting with early enteral nutrition, pain control, pulmonary toilet, and staged imaging (contrast swallow) to assess anastomotic integrity prior to initiating oral intake. Typical sites of service are an inpatient operating room with postoperative stay in a surgical ward or ICU. Common team members include thoracic or general surgeons with esophageal expertise, anesthesiologists, surgical assistants, intensivists, nutritionists, and wound/ostomy nurses.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    43235Esophagoscopy, flexible, diagnostic, with or without collection of specimen(s) by brushing or forcepsPreoperative diagnostic endoscopy and biopsy to establish diagnosis and plan for CPT 43122.
    43247Endoscopic ultrasound, esophagus (EUS) with FNA when performedStaging of esophageal cancer to assess tumor depth and regional nodes prior to resection.
    39501Thoracotomy; with exploration (separate procedure)May be performed as the thoracic access component when a transthoracic approach is selected for CPT 43122.
    43842Gastric resection, partial; distal gastrectomy (includes anastomosis)When a partial gastrectomy is required as part of reconstruction after esophageal resection.
    43770Laparoscopy, surgical, gastric restrictive procedure (eg, sleeve gastrectomy)Laparoscopic mobilization or conduit preparation is sometimes used in minimally invasive esophagectomy approaches.
    43254Esophagoscopy, flexible, with dilation of stenosis or stricturePerformed preoperatively for palliation or temporizing dilation prior to definitive esophagectomy.

    Related Modifiers

    13 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…

    Showing 1–10 of 13

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207K00000X
    2084P0800X
    207L00000X
    208600000X
    163WP0200X
    226000000X
    2080A0000X
    2279G1100X

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    B37.9Candidiasis, unspecified
    C15.3Malignant neoplasm of upper third of esophagus
    C15.4Malignant neoplasm of middle third of esophagus
    C15.8Malignant neoplasm of overlapping sites of esophagus
    C15.9Malignant neoplasm of esophagus, unspecified
    C16.1Malignant neoplasm of fundus of stomach
    C16.2Malignant neoplasm of body of stomach
    I85.00Esophageal varices without bleeding
    I85.01Esophageal varices with bleeding
    K21.9Gastro-esophageal reflux disease without esophagitis

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01

    Related Codes

    CPT-43100-CERVICAL-ESOPHAGEAL-LESION-EXCISION

    CPT 43100: Excision of Lesion From Cervical Esophagus

    CPT-43101-ESOPHAGEAL-LESION-EXCISION-THORACIC-ABDOMINAL-APPROACH

    CPT 43101: Excision of Esophageal Lesion via Thoracic or Abdominal Incision

    CPT-43107-ESOPHAGECTOMY-CERVICAL-ESOPHAGOGASTRIC-RECONSTRUCTION

    CPT 43107: Transcervical Esophagectomy with Gastric-Pharyngeal Reconstruction

    CPT-43108-ESOPHAGECTOMY-NON-THORACOTOMY-WITH-BOWEL-GRAFT-RECONSTRUCTION

    CPT 43108: Esophagectomy with Small Bowel or Colon Interposition, Nonthoracotomy

    CPT-43112-MCKEOWN-TRI-INCISIONAL-ESOPHAGECTOMY

    CPT 43112: McKeown (Tri-incisional) Total Esophagectomy with Gastric Pull-up

    CPT-43113-ESOPHAGECTOMY-WITH-INTESTINAL-GRAFT-THROUGH-CHEST

    CPT 43113: Esophagectomy with Small Bowel or Colon Reconstruction, Thoracic Approach

    CPT-43116-ESOPHAGECTOMY-WITH-INTESTINAL-GRAFT-RECONSTRUCTION

    CPT 43116: Esophagectomy with Intestinal Graft in Cervical Esophagus

    CPT-43117-ESOPHAGECTOMY-DISTAL-TWO-THIRDS-WITH-GASTRIC-RECONSTRUCTION

    CPT 43117: Subtotal Esophagectomy with Gastric Conduit, Abdominal and Thoracic Approach

    CPT-43118-ESOPHAGECTOMY-DISTAL-TWO-THIRDS-WITH-INTESTINAL-INTERPOSITION

    CPT 43118: Esophagectomy with Reconstruction (Thoracoabdominal)

    CPT-43121-TRANSTHORACIC-ESOPHAGECTOMY-DISTAL-TWO-THIRDS

    CPT 43121: Distal Two-Thirds Esophagectomy via Chest Incision

    Showing 1–10 of 14

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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