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    v1.0.30
    OpenPayerBilling CodesExcision Procedures on the EsophagusCPT cpt-43101-esophageal-lesion-excision-thoracic-abdominal-approach
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    CPT 43101: Excision of Esophageal Lesion via Thoracic or Abdominal Incision

    Medicare pays $977 on average nationally for this procedure.

    CPT code 43101 describes a surgical procedure in which the provider makes a thoracic or abdominal incision to perform an excision of a lesion in the esophagus, classified as an open surgical resection; the service type is operative surgical excision and the typical site of service is an inpatient or outpatient hospital operating room depending on clinical indications and perioperative needs.

    For related coverage guidance, see recent payer policy updates: Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Esophagogastroduodenoscopy (EGD) Coverage Policy, Radiofrequency Therapy for Fecal Incontinence.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 62-year-old male with progressive dysphagia and weight loss is diagnosed on endoscopy with a suspicious sessile lesion in the mid-esophagus. Biopsy is inconclusive for deep invasion, and imaging suggests a localized lesion without distant metastasis. The thoracic surgery team schedules an open esophagectomy or segmental esophageal resection via a thoracotomy or abdominal approach to excise the lesion and obtain adequate margins; intraoperative frozen section may be used. Preoperative workflow includes surgical consent, airway evaluation, pre-op labs and imaging, anesthesia assessment, and marking for a thoracic or upper abdominal incision. Intraoperative steps include exposure of the esophagus through a right or left thoracotomy or upper midline laparotomy depending on lesion location, resection of the lesion with margins, reconstruction or primary anastomosis as indicated, and placement of drains. Postoperative care includes ICU monitoring as needed, pain control, enteral nutrition planning, and surveillance for complications such as anastomotic leak, bleeding, or recurrent laryngeal nerve injury.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    43101Entering thoracic or abdominal cavity with excision of lesion of esophagus (primary code in context)Primary procedure for excision of an esophageal lesion via thoracic or abdominal incision
    43280Esophagogastroduodenoscopy, flexible, diagnostic, with biopsy, single or multiplePreoperative endoscopic evaluation and biopsy to identify lesion and obtain pathology
    43249Endoscopic mucosal resection (EMR) or submucosal dissection of esophageal lesionMinimally invasive alternative for some superficial lesions; may be performed instead of 43101 or prior to open resection if incomplete
    43320Esophagomyotomy, with partial fundoplication (Heller)Not routine for lesion excision but may be performed in combined foregut procedures when dysphagia due to motility disturbance coexists
    43112Transthoracic partial esophagectomy with intrathoracic anastomosisMore extensive resection that may be performed when 43101 is not sufficient for oncologic margins
    43760Revision of Roux-en-Y or reconstruction of gastrointestinal tractMay be used if reconstruction or complex alimentary tract reconstruction is required after esophageal resection

    Related Modifiers

    13 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    66Modifier 66 (Surgical Team) is used when three or more surgeons act as primary surgeons on a single, highly complex procedure. The AMA defines it for use when a surgical team — often composed of…- Use modifier 66 when three or more surgeons act as primary surgeons working collaboratively as a surgical team on a single, highly complex or difficult procedure (for example organ…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Showing 1–10 of 13

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207L00000X
    207K00000X
    207RP1001X
    2086S0102X
    207QG0300X
    324500000X
    225100000X
    261QH0100X

    Related ICD-10-CM Codes

    20 rows

    ICD-10-CM CodeDescription
    C15.3Malignant neoplasm of upper third of esophagus
    C15.4Malignant neoplasm of middle third of esophagus
    C15.5Malignant neoplasm of lower third of esophagus
    C15.8Malignant neoplasm of overlapping sites of esophagus
    C15.9Malignant neoplasm of esophagus, unspecified
    D13.1Benign neoplasm of stomach
    I85.00Esophageal varices without bleeding
    I85.01Esophageal varices with bleeding
    I85.10Secondary esophageal varices without bleeding
    K21.9Gastro-esophageal reflux disease without esophagitis

    Showing 1–10 of 20

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01

    Related Codes

    CPT-43100-CERVICAL-ESOPHAGEAL-LESION-EXCISION

    CPT 43100: Excision of Lesion From Cervical Esophagus

    CPT-43107-ESOPHAGECTOMY-CERVICAL-ESOPHAGOGASTRIC-RECONSTRUCTION

    CPT 43107: Transcervical Esophagectomy with Gastric-Pharyngeal Reconstruction

    CPT-43108-ESOPHAGECTOMY-NON-THORACOTOMY-WITH-BOWEL-GRAFT-RECONSTRUCTION

    CPT 43108: Esophagectomy with Small Bowel or Colon Interposition, Nonthoracotomy

    CPT-43112-MCKEOWN-TRI-INCISIONAL-ESOPHAGECTOMY

    CPT 43112: McKeown (Tri-incisional) Total Esophagectomy with Gastric Pull-up

    CPT-43113-ESOPHAGECTOMY-WITH-INTESTINAL-GRAFT-THROUGH-CHEST

    CPT 43113: Esophagectomy with Small Bowel or Colon Reconstruction, Thoracic Approach

    CPT-43116-ESOPHAGECTOMY-WITH-INTESTINAL-GRAFT-RECONSTRUCTION

    CPT 43116: Esophagectomy with Intestinal Graft in Cervical Esophagus

    CPT-43117-ESOPHAGECTOMY-DISTAL-TWO-THIRDS-WITH-GASTRIC-RECONSTRUCTION

    CPT 43117: Subtotal Esophagectomy with Gastric Conduit, Abdominal and Thoracic Approach

    CPT-43118-ESOPHAGECTOMY-DISTAL-TWO-THIRDS-WITH-INTESTINAL-INTERPOSITION

    CPT 43118: Esophagectomy with Reconstruction (Thoracoabdominal)

    CPT-43121-TRANSTHORACIC-ESOPHAGECTOMY-DISTAL-TWO-THIRDS

    CPT 43121: Distal Two-Thirds Esophagectomy via Chest Incision

    CPT-43122-PARTIAL-ESOPHAGECTOMY-ESOPHAGOGASTROSTOMY

    CPT 43122: Partial Esophagectomy with Esophagogastric Anastomosis

    Showing 1–10 of 14

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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