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    v1.0.30
    OpenPayerBilling CodesExcision Procedures on the EsophagusCPT cpt-43100-cervical-esophageal-lesion-excision
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    CPT 43100: Excision of Lesion From Cervical Esophagus

    Medicare pays $569 on average nationally for this procedure.

    CPT code 43100 describes a surgical procedure in which the provider makes an incision in the neck to excise a lesion from the esophagus; this is an open surgical excision of an esophageal lesion performed via a cervical approach and is typically categorized as a surgical procedure with the usual site of service being an operating room or other sterile surgical suite in an inpatient or outpatient hospital setting.

    For related coverage guidance, see recent payer policy updates: Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disorders, Esophagogastroduodenoscopy (EGD) Coverage Policy, Radiofrequency Therapy for Fecal Incontinence.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 62-year-old male presents with progressive dysphagia and intermittent odynophagia. Endoscopic evaluation identifies a 2.5 cm intraluminal mass in the cervical esophagus approximately 18 cm from the incisors causing partial obstruction. Biopsy is indeterminate for malignancy. After multidisciplinary review, the patient is scheduled for a surgical excision via a neck incision. The patient receives preoperative anesthesia evaluation, informed consent documenting risks (bleeding, infection, recurrent laryngeal nerve injury, esophageal leak), and appropriate imaging (contrast esophagram or CT neck/chest) to plan the cervical approach. In the operating room under general anesthesia, the surgeon makes a left-sided cervical incision, dissects to the esophageal adventitia, performs an esophagotomy, excises the lesion with clear margins, repairs the esophageal wall, and places drains as indicated. Postoperative workflow includes monitored recovery for airway concerns, nil per os with enteral nutrition as needed, serial neck exams, contrast swallow study prior to oral diet advancement, pathology review, and follow-up with surgery and ENT as needed.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    43280Esophagoscopy, flexible, transoral; diagnostic, with or without collection of specimen(s) by brushing or washingPreoperative endoscopic evaluation and biopsy to localize lesion and obtain tissue sampling prior to surgical excision.
    43249Endoscopic, transoral, excision or resection of lesion(s) of esophagus; single lesionMinimally invasive alternative for selected intraluminal lesions amenable to endoscopic resection instead of cervical incision.
    43112Esophagoplasty, with intrathoracic anastomosis; for repair following laceration or resectionPerformed when more extensive esophageal repair or resection with reconstruction is required beyond simple excision.
    43770Esophagomyotomy, Heller type; via thoracotomy or thoracoscopyRelated esophageal surgery for functional disorders; included when combined procedures address motility issues discovered intraoperatively.
    43760Esophagectomy, partial, mobilization of stomach with intrathoracic anastomosisMore extensive resection if lesion proves malignant or invades adjacent structures requiring partial esophagectomy.

    Related Modifiers

    11 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    81Modifier -81 indicates a physician served as a minimal assistant surgeon for part—not all—of an operative procedure. Use when a physician’s assisting role is limited and does not represent full…- Use CPT modifier -81 when a physician acts as a minimum assistant surgeon who assists during only part (a limited portion) of an operative procedure; append -81 to the primary surgical CPT code to…

    Showing 1–10 of 11

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207K00000X
    2086S0122X
    207ZP0105X
    207RH0000X
    207P00000X
    2865C1500X
    251T00000X
    103G00000X

    Related ICD-10-CM Codes

    22 rows

    ICD-10-CM CodeDescription
    C15.3Malignant neoplasm of upper third of esophagus
    C15.4Malignant neoplasm of middle third of esophagus
    C15.8Malignant neoplasm of overlapping sites of esophagus
    C15.9Malignant neoplasm of esophagus, unspecified
    I85.00Esophageal varices without bleeding
    I85.01Esophageal varices with bleeding
    K21.9Gastro-esophageal reflux disease without esophagitis
    K22.0Achalasia of cardia
    K22.2Esophageal obstruction
    K22.6Gastro-esophageal laceration-hemorrhage syndrome

    Showing 1–10 of 22

    Related Payer Policy Updates

    Specialty: Gastroenterology1 / 3

    10 rows

    PolicyPayerEffective Date
    Percutaneous Electrical Nerve Field Stimulation for Functional Abdominal Pain Disordersbcbsvermont2026-12-01
    Esophagogastroduodenoscopy (EGD) Coverage Policyevicore2026-11-05
    Radiofrequency Therapy for Fecal IncontinenceCigna2026-10-15
    Magnetic Sphincter Augmentation for the Treatment of Gastroesophageal Reflux Disease (GERD)univerahealthcare2026-10-15
    High-Resolution Anoscopy (HRA)Premera Bluecross2026-10-01
    Gastroesophageal and Gastrointestinal (GI) Services and ProceduresColorado Rocky Mountain Health Plans2026-10-01
    Fecal Analysis in the Diagnosis of Intestinal Dysbiosis and Fecal Microbiota Transplant TestingOscar Health2026-10-01
    Serum Testing for Hepatic Fibrosis in the Evaluation and Monitoring of Chronic Liver DiseaseOscar Health2026-10-01
    Pancreatic Enzyme Testing for Acute PancreatitisOscar Health2026-10-01
    Helicobacter pylori TestingOscar Health2026-10-01

    Related Codes

    CPT-43101-ESOPHAGEAL-LESION-EXCISION-THORACIC-ABDOMINAL-APPROACH

    CPT 43101: Excision of Esophageal Lesion via Thoracic or Abdominal Incision

    CPT-43107-ESOPHAGECTOMY-CERVICAL-ESOPHAGOGASTRIC-RECONSTRUCTION

    CPT 43107: Transcervical Esophagectomy with Gastric-Pharyngeal Reconstruction

    CPT-43108-ESOPHAGECTOMY-NON-THORACOTOMY-WITH-BOWEL-GRAFT-RECONSTRUCTION

    CPT 43108: Esophagectomy with Small Bowel or Colon Interposition, Nonthoracotomy

    CPT-43112-MCKEOWN-TRI-INCISIONAL-ESOPHAGECTOMY

    CPT 43112: McKeown (Tri-incisional) Total Esophagectomy with Gastric Pull-up

    CPT-43113-ESOPHAGECTOMY-WITH-INTESTINAL-GRAFT-THROUGH-CHEST

    CPT 43113: Esophagectomy with Small Bowel or Colon Reconstruction, Thoracic Approach

    CPT-43116-ESOPHAGECTOMY-WITH-INTESTINAL-GRAFT-RECONSTRUCTION

    CPT 43116: Esophagectomy with Intestinal Graft in Cervical Esophagus

    CPT-43117-ESOPHAGECTOMY-DISTAL-TWO-THIRDS-WITH-GASTRIC-RECONSTRUCTION

    CPT 43117: Subtotal Esophagectomy with Gastric Conduit, Abdominal and Thoracic Approach

    CPT-43118-ESOPHAGECTOMY-DISTAL-TWO-THIRDS-WITH-INTESTINAL-INTERPOSITION

    CPT 43118: Esophagectomy with Reconstruction (Thoracoabdominal)

    CPT-43121-TRANSTHORACIC-ESOPHAGECTOMY-DISTAL-TWO-THIRDS

    CPT 43121: Distal Two-Thirds Esophagectomy via Chest Incision

    CPT-43122-PARTIAL-ESOPHAGECTOMY-ESOPHAGOGASTROSTOMY

    CPT 43122: Partial Esophagectomy with Esophagogastric Anastomosis

    Showing 1–10 of 14

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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