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    v1.0.30
    OpenPayerBilling CodesExcision and Destruction Procedures on the Pharynx, Adenoids, and TonsilsCPT cpt-42804-nasopharyngeal-lesion-biopsy
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    CPT 42804: Biopsy of Visible Nasopharyngeal Lesion

    Medicare pays $224 on average nationally for this procedure.

    CPT code 42804 describes a procedure in which the provider obtains a biopsy sample from a visible lesion of the nasopharynx; this is an operative/diagnostic biopsy procedure typically performed in an ambulatory surgery center or outpatient clinic or the operating room under appropriate visualization of the nasopharynx to collect tissue for histopathologic examination.

    For related coverage guidance, see recent payer policy updates: Dental Anesthesia Services, Anesthesia Services for Interventional Pain Management Procedures in an Adult, General Anesthesia and Conscious Sedation Services.

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old male presents to an otolaryngology clinic with unilateral nasal obstruction and intermittent epistaxis. Nasal endoscopy identifies a suspicious, visible lesion on the nasopharyngeal wall. After discussion of risks and benefits, the otolaryngologist performs a targeted nasopharyngeal biopsy under local anesthesia with endoscopic visualization. The specimen is placed in formalin and sent to pathology for histologic diagnosis. Typical workflow includes pre-procedure consent, topical anesthesia and vasoconstriction, endoscopic visualization, targeted biopsy using forceps or a punch instrument, specimen handling and labeling, and post-procedure monitoring for bleeding or airway compromise. Typical site of service is an outpatient otolaryngology clinic or ambulatory surgery center; hospital outpatient setting can be used for patients requiring monitored anesthesia or complex comorbidity management. Common clinical indications include palpable/visual nasopharyngeal masses, suspected nasopharyngeal carcinoma, chronic unilateral serous otitis media with an associated mass, or unexplained epistaxis with an identified lesion.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    31231Nasal/sinus endoscopy, diagnostic, with or without collection of specimen(s)Endoscopic evaluation commonly performed immediately before a nasopharyngeal biopsy for visualization and guidance
    42820Excision, tumor, nasopharynx; benignPerformed when the lesion is excised definitively rather than sampled; may follow a positive biopsy
    42821Excision, tumor, nasopharynx; malignantDefinitive surgical resection code used if pathology confirms malignancy and a formal excision is performed
    99100Anesthesia for procedures on head, neck, including general anesthesiaUsed when general anesthesia or monitored anesthesia care is provided for patient comfort or complexity
    49405Data not available in the input.Data not available in the input.

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Y00000X
    208D00000X
    367A00000X
    207K00000X
    163WP0200X
    2086S0122X
    102L00000X
    302R00000X

    Related ICD-10-CM Codes

    28 rows

    ICD-10-CM CodeDescription
    C09.0Malignant neoplasm of tonsillar fossa
    C09.1Malignant neoplasm of tonsillar pillar (anterior) (posterior)
    C10.0Malignant neoplasm of vallecula
    C10.9Malignant neoplasm of oropharynx, unspecified
    C11.9Malignant neoplasm of nasopharynx, unspecified
    D14.2Benign neoplasm of trachea
    D37.9Neoplasm of uncertain behavior of digestive organ, unspecified
    D38.1Neoplasm of uncertain behavior of trachea, bronchus and lung
    D49.0Neoplasm of unspecified behavior of digestive system
    J00Acute nasopharyngitis [common cold]

    Showing 1–10 of 28

    Related Payer Policy Updates

    Specialty: Anesthesiology1 / 3

    10 rows

    PolicyPayerEffective Date
    Dental Anesthesia ServicesProvidence Health Plan2026-10-01
    Anesthesia Services for Interventional Pain Management Procedures in an AdultCigna2026-09-15
    General Anesthesia and Conscious Sedation ServicesUnitedHealthcare2026-09-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Elective Inpatient Services (for Idaho Only)UnitedHealthcare2026-06-01
    Sites of Servicepriority health2026-06-01
    Coverage for Ambulatory Surgery Unit (ASU)/Outpatient Facility and Anesthesia for Dental Servicesuniverahealthcare2026-05-21

    Related Codes

    CPT-42800-OROPHARYNGEAL-BIOPSY

    CPT 42800: Biopsy, Oropharynx

    CPT-42806-NASOPHARYNGEAL-BIOPSY-UNKNOWN-PRIMARY-LESION

    CPT 42806: Biopsy of Nasopharyngeal Lesion, Unknown Primary

    CPT-42808-PHARYNGEAL-LESION-DESTRUCTION-LASER-CRYOSURGERY

    CPT 42808: Pharynx Lesion Destruction (Laser, Cryosurgery, Electrocautery)

    CPT-42809-PHARYNX-FOREIGN-BODY-REMOVAL

    CPT 42809: Removal of Foreign Body from Pharynx

    CPT-42810-BRACHIAL-CLEFT-CYST-EXCISION

    CPT 42810: Excision of Brachial Cleft Cyst, Lateral Neck

    CPT-42815-BRACHIAL-CLEFT-CYST-EXCISION

    CPT 42815: Excision of Brachial Cleft Cyst, Lateral Neck

    CPT-42820-TONSILLECTOMY-AND-ADENOIDECTOMY-YOUNGER-THAN-12

    CPT 42820: Tonsillectomy and Adenoidectomy, Patient Younger Than 12 Years

    CPT-42821-TONSILLECTOMY-ADENOIDECTOMY-AGE-12-PLUS

    CPT 42821: Tonsillectomy with Adenoidectomy, Age 12 or Older

    CPT-42825-PEDIATRIC-TONSILLECTOMY-UNDER-12

    CPT 42825: Tonsillectomy in Patients Under 12 Years

    CPT-42826-TONSILLECTOMY-AGE-12-AND-OLDER

    CPT 42826: Tonsillectomy for Patients Age 12 and Older

    Showing 1–10 of 22

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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