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    OpenPayerBilling CodesExcision and Destruction Procedures on the Palate and UvulaCPT cpt-42120-palatal-lesion-resection-wide-area
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    CPT 42120: Wide Resection of Palatal/Oral Lesion

    Medicare pays $937 on average nationally for this procedure.

    CPT code 42120 describes a surgical resection of a lesion involving a wide area or resection of the palate, typically performed for a malignant neoplasm; service type: surgical resection of oral/palatal lesion; typical site of service: operating room or ambulatory surgical center for head and neck surgery under general anesthesia.

    For related coverage guidance, see recent payer policy updates: Dental Anesthesia Services, Anesthesia Services for Interventional Pain Management Procedures in an Adult, General Anesthesia and Conscious Sedation Services.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult referred to an otolaryngologist or oral/maxillofacial surgeon for resection of a suspected or confirmed malignant lesion of the hard or soft palate. The patient often presents with progressively enlarging palatal mass, ulceration, pain, bleeding, or difficulty with swallowing/speech. Preoperative workup includes head and neck examination, flexible nasopharyngoscopy, imaging (contrast-enhanced CT or MRI of the head and neck), and biopsy confirming malignancy (for example, squamous cell carcinoma). The clinical workflow: initial evaluation and biopsy by the surgeon or ENT, staging with imaging and possible dental/oral oncology consultation, preoperative medical clearance, operative resection of the lesion and involved palate with appropriate margins under general anesthesia, intraoperative frozen section evaluation as needed, reconstruction (local flap, free flap, or obturator) often performed in the same setting or staged, postoperative monitoring in PACU and inpatient setting, pathology review for margin status, and coordination of adjuvant radiation or chemoradiation with medical/radiation oncology if indicated. Typical site of service is an ambulatory surgery center or hospital operating room. Service type is major surgical resection of oral cavity/palatal malignant lesion under general anesthesia.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    31575Laryngoscopy, direct, with biopsyPreoperative or intraoperative endoscopic evaluation and biopsy of upper aerodigestive tract lesions; may be used in workup or synchronous procedures.
    21015Excision of lesion of hard palate, partial maxillectomy, en blocAlternative or adjacent procedure for larger palatal/maxillary resections; may be performed if resection extends into maxilla.
    21210Reconstruction of palate with local flapCommon reconstructive procedure performed at the time of palatal resection to restore function and separation of oral/nasal cavities.
    88305Pathology, surgical pathology, gross and microscopic examinationRoutine permanent pathology examination of resected specimen to determine diagnosis and margins.
    96401Chemotherapy administration, IV infusion (example)May be used later in the treatment plan for systemic therapy when indicated as adjuvant treatment (administration code placeholder).

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207P00000X
    208100000X
    207L00000X
    207R00000X
    261QR0401X
    261QA0900X
    207SG0201X
    2278P1005X

    Related Payer Policy Updates

    Specialty: Anesthesiology1 / 3

    10 rows

    PolicyPayerEffective Date
    Dental Anesthesia ServicesProvidence Health Plan2026-10-01
    Anesthesia Services for Interventional Pain Management Procedures in an AdultCigna2026-09-15
    General Anesthesia and Conscious Sedation ServicesUnitedHealthcare2026-09-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Elective Inpatient Services (for Idaho Only)UnitedHealthcare2026-06-01
    Sites of Servicepriority health2026-06-01
    Coverage for Ambulatory Surgery Unit (ASU)/Outpatient Facility and Anesthesia for Dental Servicesuniverahealthcare2026-05-21

    Related Codes

    CPT-42100-PALATE-UVULA-TISSUE-REMOVAL-PATHOLOGY

    CPT 42100: Excision of Palate or Uvula Tissue for Pathology

    CPT-42104-PALATE-UVULA-LESION-EXCISION-NO-CLOSURE

    CPT 42104: Excision of Lesion from Palate or Uvula, No Closure

    CPT-42106-PALATE-UVULA-LESION-EXCISION-SIMPLE-REPAIR

    CPT 42106: Excision of Lesion, Palate or Uvula; Simple Repair

    CPT-42107-PALATE-UVULA-LESION-EXCISION-LOCAL-FLAP

    CPT 42107: Excision of Palate or Uvula Lesion with Local Flap Closure

    CPT-42140-UVULOPALATOPHARYNGOPLASTY-UVULA-REMOVAL

    CPT 42140: Uvula Removal for Snoring

    CPT-42145-PALATOPHARYNGOPLASTY-UVULOPALATOPHARYNGOPLASTY

    CPT 42145: Palatopharyngoplasty for Oropharyngeal Airway Widening

    CPT-42160-PALATE-UVULA-LESION-DESTRUCTION

    CPT 42160: Destruction of Lesion on Palate or Uvula

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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