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    OpenPayerBilling CodesExcision and Destruction Procedures on the Palate and UvulaCPT cpt-42100-palate-uvula-tissue-removal-pathology
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    CPT 42100: Excision of Palate or Uvula Tissue for Pathology

    Medicare pays $155 on average nationally for this procedure.

    CPT code 42100 describes the surgical removal of tissue from the palate or uvula for pathological analysis, a minor operative specimen excision procedure typically performed in an outpatient surgical suite or ambulatory surgery center and classified as an otolaryngology/head and neck soft tissue excision service.

    For related coverage guidance, see recent payer policy updates: Dental Anesthesia Services, Anesthesia Services for Interventional Pain Management Procedures in an Adult, General Anesthesia and Conscious Sedation Services.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 45-year-old adult referred to an otolaryngology clinic for evaluation of a suspicious palatal lesion or persistent uvular mass. The patient reports a focal area of ulceration or a firm nodular lesion on the soft palate or uvula that has failed conservative therapy or has concerning features (rapid growth, induration, bleeding). Examination in clinic using topical anesthesia demonstrates a discrete lesion amenable to outpatient excisional biopsy. The clinical workflow includes pre-procedure consent, topical or local infiltration anesthesia in the clinic or ambulatory surgery center, excisional or incisional removal of the palatal or uvular tissue, hemostasis, specimen labeling and submission to pathology, and brief post-procedure observation with discharge instructions. Typical sites of service are outpatient clinic procedure room or ambulatory surgery center; the procedure may occasionally be performed in an operating room for larger or complex lesions. Pathology processing and interpretation are separate services reported by the laboratory/pathologist when applicable.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    40490Incision and drainage of peritonsillar abscess; without drainage of tonsillar cryptsMay be performed if lesion represents an abscess requiring drainage rather than biopsy.
    42120Simple tonsillectomy and adenoidectomy; tonsillectomy with or without adenoidectomy, younger than 12 yearsMay be part of a broader or concurrent oropharyngeal surgical plan in pediatric cases.
    40499Unlisted procedure, nose, septum, turbinates (used for atypical or complex palatal procedures when no specific code exists)Used when a palatal procedure is unusual and no specific CPT code applies.
    88305Level IV surgical pathology, gross and microscopic examinationCommon pathology CPT for tissue submitted after biopsy; billed by the laboratory/pathologist.
    99213Office or other outpatient visit for the evaluation and management of an established patient, low to moderate complexityTypical pre- or post-procedure outpatient E/M visit associated with the biopsy.

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    58Modifier 58 (Staged or related procedure/service by the same physician during the postoperative period) indicates that a subsequent procedure performed by the same provider during the…- Use modifier 58 when the same physician/QHP performs a procedure during the postoperative/global period of an earlier procedure and the subsequent procedure is either planned or anticipated…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    208D00000X
    207K00000X
    2080P0206X
    207L00000X
    363LF0000X
    283XC2000X
    1223G0001X
    207LA0401X

    Related ICD-10-CM Codes

    29 rows

    ICD-10-CM CodeDescription
    C09.0Malignant neoplasm of tonsillar fossa
    C10.9Malignant neoplasm of oropharynx, unspecified
    D49.2Neoplasm of unspecified behavior of bone, soft tissue, and skin
    F45.8Other somatoform disorders
    G47.00Insomnia, unspecified
    J02.9Acute pharyngitis, unspecified
    J34.2Deviated nasal septum
    J34.89Other specified disorders of nose and nasal sinuses
    J35.1Hypertrophy of tonsils
    J35.3Hypertrophy of tonsils with hypertrophy of adenoids

    Showing 1–10 of 29

    Related Payer Policy Updates

    Specialty: Anesthesiology1 / 3

    10 rows

    PolicyPayerEffective Date
    Dental Anesthesia ServicesProvidence Health Plan2026-10-01
    Anesthesia Services for Interventional Pain Management Procedures in an AdultCigna2026-09-15
    General Anesthesia and Conscious Sedation ServicesUnitedHealthcare2026-09-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Intravenous Anesthetics for the Treatment of Chronic Pain and Psychiatric or Substance Use DisordersPremera Bluecross2026-07-01
    Elective Inpatient Services (for Idaho Only)UnitedHealthcare2026-06-01
    Sites of Servicepriority health2026-06-01
    Coverage for Ambulatory Surgery Unit (ASU)/Outpatient Facility and Anesthesia for Dental Servicesuniverahealthcare2026-05-21

    Related Codes

    CPT-42104-PALATE-UVULA-LESION-EXCISION-NO-CLOSURE

    CPT 42104: Excision of Lesion from Palate or Uvula, No Closure

    CPT-42106-PALATE-UVULA-LESION-EXCISION-SIMPLE-REPAIR

    CPT 42106: Excision of Lesion, Palate or Uvula; Simple Repair

    CPT-42107-PALATE-UVULA-LESION-EXCISION-LOCAL-FLAP

    CPT 42107: Excision of Palate or Uvula Lesion with Local Flap Closure

    CPT-42120-PALATAL-LESION-RESECTION-WIDE-AREA

    CPT 42120: Wide Resection of Palatal/Oral Lesion

    CPT-42140-UVULOPALATOPHARYNGOPLASTY-UVULA-REMOVAL

    CPT 42140: Uvula Removal for Snoring

    CPT-42145-PALATOPHARYNGOPLASTY-UVULOPALATOPHARYNGOPLASTY

    CPT 42145: Palatopharyngoplasty for Oropharyngeal Airway Widening

    CPT-42160-PALATE-UVULA-LESION-DESTRUCTION

    CPT 42160: Destruction of Lesion on Palate or Uvula

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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