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    v1.0.30
    OpenPayerBilling CodesExcision Procedures on the Tongue and Floor of MouthCPT cpt-41108-floor-of-mouth-biopsy-excision
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    CPT 41108: Incision and Excision of Tissue, Floor of Mouth for Biopsy

    Medicare pays $177 on average nationally for this procedure.

    CPT code 41108 describes an incision in the floor of the mouth with excision of tissue for biopsy, a minor surgical procedure performed to obtain diagnostic tissue from the oral floor; service type: biopsy/tissue excision, typical site of service: ambulatory surgical center or outpatient clinic/procedure room.

    For related coverage guidance, see recent payer policy updates: Orthopedic Joint Procedures of the Knee for Managed Medicaid (MMC), Health and Recovery Plan (HARP), Child Health Plus (CHP), and Essential Plan (EP) Members, Autologous Chondrocyte Transplantation or Implantation Corporate Medical Policy, Autologous Platelet-Derived Growth Factors (Platelet-Rich Plasma [PRP]).

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 48-year-old patient presents to the oral and maxillofacial surgery clinic with a 2-week history of a small, firm, non-ulcerated mass palpable in the midline floor of mouth beneath the tongue. The lesion is clinically suspicious for neoplasm or chronic sialadenitis of a nearby minor salivary gland. After history, exam, and review of imaging (panoramic radiograph and ultrasound), the surgeon schedules a diagnostic excisional biopsy under local anesthesia with possible conversion to general anesthesia if airway or patient tolerance requires it. In the procedure room or ambulatory surgery center, the provider performs an incision in the floor of the mouth, isolates the lesion, excises the tissue down to submucosal planes, achieves hemostasis, and sends the specimen for pathology. Post-procedure, the patient is observed for airway compromise and oral bleeding, receives wound care instructions, and a pathology report follows to guide further treatment such as definitive excision if malignancy is identified.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    40805Excision of sublingual glandPerformed when lesion arises from or involves the sublingual gland and requires gland excision beyond biopsy
    41010Biopsy of tongue or floor of mouth, incisionalAlternate biopsy code when only a portion of a larger lesion is sampled rather than full excision
    40800Excision of lesion of floor of mouth, simpleWhen a larger definitive excision is performed rather than limited biopsy, often used if pathology suggests benign lesion and margins taken
    42320Surgical drainage of abscess of floor of mouth (Ludwig angina)Performed for infectious processes of the floor of mouth requiring incision and drainage, distinct from diagnostic biopsy
    99213Office established patient visit, intermediateTypical pre- or post-procedure evaluation visit code used in clinic workflow for history, consent, and follow-up

    Related Modifiers

    12 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…

    Showing 1–10 of 12

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207Q00000X
    207RI0011X
    208000000X
    207V00000X
    2082S0105X
    385HR2060X
    207PE0004X
    242T00000X

    Related Payer Policy Updates

    Specialty: Orthopedics/Musculoskeletal1 / 2

    10 rows

    PolicyPayerEffective Date
    Orthopedic Joint Procedures of the Knee for Managed Medicaid (MMC), Health and Recovery Plan (HARP), Child Health Plus (CHP), and Essential Plan (EP) Membersuniverahealthcare2027-01-01
    Autologous Chondrocyte Transplantation or Implantation Corporate Medical Policybcbsvermont2026-12-01
    Autologous Platelet-Derived Growth Factors (Platelet-Rich Plasma [PRP])Cigna2026-10-15
    Metatarsophalangeal Joint ReplacementCigna2026-10-15
    Shoulder Arthroplasty (Total, Partial, Reverse, Revision and Resurfacing)univerahealthcare2026-10-15
    Hip Arthroplasty (partial and total hip replacement)univerahealthcare2026-10-15
    Artificial Lumbar Intervertebral Disc (Lumbar Total Disc Arthroplasty)univerahealthcare2026-10-15
    Osteochondral Grafting of the Kneeuniverahealthcare2026-10-15
    Lumbar Fusion (arthrodesis) with decompressionuniverahealthcare2026-10-15
    Metal-on-Metal Total Hip Resurfacinguniverahealthcare2026-10-15

    Related Codes

    CPT-41100-TONGUE-EXCISIONAL-BIOPSY-ANTERIOR-TWO-THIRDS

    CPT 41100: Partial Glossectomy for Biopsy, Anterior Tongue

    CPT-41105-POSTERIOR-TONGUE-BIOPSY-EXCISION

    CPT 41105: Partial Excision/Biopsy of Posterior Tongue

    CPT-41110-TONGUE-LESION-EXCISION

    CPT 41110: Excision of Lesion of Tongue

    CPT-41112-TONGUE-LESION-EXCISION-ANTERIOR-TWO-THIRDS

    CPT 41112: Excision of Lesion, Anterior Two-Thirds of Tongue

    CPT-41113-EXCISION-LESION-POSTERIOR-TONGUE

    CPT 41113: Excision of Lesion, Posterior One Third of Tongue

    CPT-41114-TONGUE-LESION-EXCISION-LOCAL-FLAP-REPAIR

    CPT 41114: Excision of Tongue Lesion with Local Flap Repair

    CPT-41115-LINGUAL-FRENUM-EXCISION-BASE-OF-TONGUE

    CPT 41115: Frenulectomy, Excision of Lingual Frenum

    CPT-41116-FLOOR-OF-MOUTH-LESION-EXCISION

    CPT 41116: Excision of Lesion, Floor of Mouth

    CPT-41120-PARTIAL-GLOSSECTOMY-LESS-THAN-HALF-TONGUE

    CPT 41120: Partial Glossectomy, Less Than Half of Tongue

    CPT-41130-PARTIAL-GLOSSECTOMY-LATERAL-TONGUE-RESECTION

    CPT 41130: Partial Glossectomy, Lateral Half of Tongue

    Showing 1–10 of 16

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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