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    v1.0.30
    OpenPayerBilling CodesExcision Procedures on the Tongue and Floor of MouthCPT cpt-41100-tongue-excisional-biopsy-anterior-two-thirds
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    CPT 41100: Partial Glossectomy for Biopsy, Anterior Tongue

    Medicare pays $195 on average nationally for this procedure.

    CPT code 41100 describes a partial glossectomy for biopsy involving an incision in the anterior two-thirds of the tongue with excision of the affected tissue; this is a surgical biopsy procedure (open surgical excision) typically performed in an operating room or procedure suite under local or general anesthesia and classified as an otolaryngology/head and neck surgical service.

    For related coverage guidance, see recent payer policy updates: Orthopedic Joint Procedures of the Knee for Managed Medicaid (MMC), Health and Recovery Plan (HARP), Child Health Plus (CHP), and Essential Plan (EP) Members, Autologous Chondrocyte Transplantation or Implantation Corporate Medical Policy, Autologous Platelet-Derived Growth Factors (Platelet-Rich Plasma [PRP]).

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old patient presents to an otolaryngology clinic with a persistent, non-healing ulcerative lesion on the anterior two-thirds of the tongue noted on exam. The patient reports mild pain, intermittent bleeding, and a recent change in lesion size. The clinician performs a focused head and neck exam, documents lesion characteristics (size, location, induration, mobility), and reviews medical history and anticoagulation status. After informed consent, the patient is taken to a procedure room or outpatient surgery suite where local anesthesia (with or without sedation) is administered. The provider makes an incision in the anterior two-thirds of the tongue and excises the lesion or affected tissue for diagnostic biopsy, controlling hemostasis and closing with absorbable sutures as indicated. Specimens are labeled and sent to pathology. Post-procedure instructions include airway precautions, diet modifications, analgesia plan, and follow-up for pathology results. Typical sites of service are the ambulatory surgical center, hospital outpatient department, or office-based procedure room depending on complexity and anesthesia needs.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    40490Biopsy, lip; excision of lesion or tissue, single or multipleAlternative oral cavity biopsy code when lesion is on lip rather than tongue; may be performed in the same clinical workflow for adjacent lesions
    41105Excision of lesion of tongue, partial glossectomy; hemiglossectomyMore extensive surgical resection when lesion requires partial glossectomy rather than localized biopsy
    41010Biopsy, oral mucosa (including tangential and punch biopsy techniques)Less extensive biopsy techniques that may be used for small, superficial tongue lesions
    99100Anesthesia for procedures performed in remote location of the hospital (e.g., radiology, MR)May be reported if additional anesthesia resources are required in a different setting; used per payer rules
    99213Office or other outpatient visit for established patient, moderate complexityTypical pre- or post-procedure office visit code for evaluation and management related to the biopsy procedure

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207L00000X
    207Q00000X
    207X00000X
    363L00000X
    261Q00000X
    2080P1004X
    207SG0205X
    207RM1200X

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    B00.2Herpesviral gingivostomatitis and pharyngotonsillitis
    B37.0Candidal stomatitis
    C01Malignant neoplasm of base of tongue
    C02.0Malignant neoplasm of dorsal surface of tongue
    C02.1Malignant neoplasm of border of tongue
    C02.2Malignant neoplasm of ventral surface of tongue
    C02.3Malignant neoplasm of anterior two-thirds of tongue, part unspecified
    C02.8Malignant neoplasm of overlapping sites of tongue
    C02.9Malignant neoplasm of tongue, unspecified
    C03.0Malignant neoplasm of upper gum

    Showing 1–10 of 27

    Related Payer Policy Updates

    Specialty: Orthopedics/Musculoskeletal1 / 2

    10 rows

    PolicyPayerEffective Date
    Orthopedic Joint Procedures of the Knee for Managed Medicaid (MMC), Health and Recovery Plan (HARP), Child Health Plus (CHP), and Essential Plan (EP) Membersuniverahealthcare2027-01-01
    Autologous Chondrocyte Transplantation or Implantation Corporate Medical Policybcbsvermont2026-12-01
    Autologous Platelet-Derived Growth Factors (Platelet-Rich Plasma [PRP])Cigna2026-10-15
    Metatarsophalangeal Joint ReplacementCigna2026-10-15
    Shoulder Arthroplasty (Total, Partial, Reverse, Revision and Resurfacing)univerahealthcare2026-10-15
    Hip Arthroplasty (partial and total hip replacement)univerahealthcare2026-10-15
    Artificial Lumbar Intervertebral Disc (Lumbar Total Disc Arthroplasty)univerahealthcare2026-10-15
    Osteochondral Grafting of the Kneeuniverahealthcare2026-10-15
    Lumbar Fusion (arthrodesis) with decompressionuniverahealthcare2026-10-15
    Metal-on-Metal Total Hip Resurfacinguniverahealthcare2026-10-15

    Related Codes

    CPT-41105-POSTERIOR-TONGUE-BIOPSY-EXCISION

    CPT 41105: Partial Excision/Biopsy of Posterior Tongue

    CPT-41108-FLOOR-OF-MOUTH-BIOPSY-EXCISION

    CPT 41108: Incision and Excision of Tissue, Floor of Mouth for Biopsy

    CPT-41110-TONGUE-LESION-EXCISION

    CPT 41110: Excision of Lesion of Tongue

    CPT-41112-TONGUE-LESION-EXCISION-ANTERIOR-TWO-THIRDS

    CPT 41112: Excision of Lesion, Anterior Two-Thirds of Tongue

    CPT-41113-EXCISION-LESION-POSTERIOR-TONGUE

    CPT 41113: Excision of Lesion, Posterior One Third of Tongue

    CPT-41114-TONGUE-LESION-EXCISION-LOCAL-FLAP-REPAIR

    CPT 41114: Excision of Tongue Lesion with Local Flap Repair

    CPT-41115-LINGUAL-FRENUM-EXCISION-BASE-OF-TONGUE

    CPT 41115: Frenulectomy, Excision of Lingual Frenum

    CPT-41116-FLOOR-OF-MOUTH-LESION-EXCISION

    CPT 41116: Excision of Lesion, Floor of Mouth

    CPT-41120-PARTIAL-GLOSSECTOMY-LESS-THAN-HALF-TONGUE

    CPT 41120: Partial Glossectomy, Less Than Half of Tongue

    CPT-41130-PARTIAL-GLOSSECTOMY-LATERAL-TONGUE-RESECTION

    CPT 41130: Partial Glossectomy, Lateral Half of Tongue

    Showing 1–10 of 16

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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