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    OpenPayerBilling CodesTransplantation and Post-Transplantation Cellular Infusion Procedures on the Hemic and Lymphatic SystemsCPT cpt-38243-donor-derived-hematopoietic-progenitor-cell-infusion
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    CPT 38243: Infusion of Donor-Derived Hematopoietic Progenitor Cells

    Medicare pays $104 on average nationally for this procedure.

    CPT code 38243 describes infusion of hematopoietic progenitor cells (HPCs) from the same transplant donor used in a prior HPC transplant; this procedure is a therapeutic cellular infusion typically performed as an outpatient or inpatient transfusion procedure within a hematology/oncology or transplant unit, and the service involves intravenous administration of donor-derived stem/progenitor cells to reestablish hematopoiesis following prior transplant therapy.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult or pediatric recipient of an allogeneic hematopoietic progenitor cell (HPC) transplant who requires infusion of additional HPCs from the same donor as part of a planned boost, rescue for poor graft function, or management of graft failure. The patient usually presents in an inpatient transplant unit or specialized outpatient infusion center after prior conditioning and transplant. Pre-infusion steps include verification of donor identity and prior transplant records, confirmation of cell product compatibility and chain-of-custody, baseline vital signs and lab evaluation (CBC, coagulation, infectious disease testing), informed consent review, and IV access placement. The procedure consists of retrieving the thawed or fresh HPC product, performing bedside checks with the transplant physician and nursing team, and infusing the product via central venous catheter under monitoring for infusion reactions. Post-infusion care includes observation for acute infusion-related events (fever, hypotension, allergic reaction), serial CBCs to assess engraftment, supportive care, and documentation of product lot numbers and cell dose. Typical sites of service are inpatient bone marrow transplant units, hospital outpatient infusion centers, or specialized ambulatory transplant clinics. Common clinical indications include poor graft function after allogeneic transplant, primary or secondary graft failure, and planned donor lymphocyte or HPC boost following hematologic malignancy treatment.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    38240Bone marrow transplantation, allogeneic; without stem cell harvestingRelated prior procedure when the patient previously received an allogeneic transplant from the same donor
    38241Bone marrow transplantation, allogeneic; with stem cell harvesting from donor and marRepresents donor collection procedures that precede HPC infusion in donor-related transplants
    36556Insertion of non-tunneled centrally inserted central venous catheter; age 5 years or olderCommonly performed pre-procedure to provide secure central access for HPC infusion
    36415Collection of venous blood by venipuncturePerformed for pre-infusion testing, crossmatch, and infectious disease assays
    99024Postoperative follow-up visit during global periodUsed for subsequent transplant follow-up visits documenting engraftment and complications

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    73Modifier 73 indicates a facility-level outpatient hospital or ASC procedure that was discontinued after the patient was prepared and taken to the procedure/operating room but before any anesthesia…- When to use: Apply CPT modifier 73 on the FACILITY (outpatient hospital or ASC) claim when the patient has been fully prepared and physically taken into the procedure/operating room but the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    2080P0207X
    208000000X
    207RC0000X
    367A00000X
    2085U0001X
    2085H0002X
    207XS0117X
    225CA2500X

    Related ICD-10-CM Codes

    25 rows

    ICD-10-CM CodeDescription
    B20Human immunodeficiency virus [HIV] disease
    C81.90Hodgkin lymphoma, unspecified, unspecified site
    C83.30Diffuse large B-cell lymphoma, unspecified site
    C85.80Other specified types of non-Hodgkin lymphoma, unspecified site
    C90.00Multiple myeloma not having achieved remission
    C91.00Acute lymphoblastic leukemia not having achieved remission
    C92.00Acute myeloblastic leukemia, not having achieved remission
    C95.90Leukemia, unspecified not having achieved remission
    D46.9Myelodysplastic syndrome, unspecified
    D47.1Chronic myeloproliferative disease

    Showing 1–10 of 25

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 2

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    CPT-38240-DONOR-HEMATOPOIETIC-PROGENITOR-CELL-INFUSION

    CPT 38240: Allogeneic Hematopoietic Progenitor Cell Transplantation

    CPT-38241-AUTOLOGOUS-HEMATOPOIETIC-PROGENITOR-CELL-REINFUSION

    CPT 38241: Autologous Hematopoietic Progenitor Cell Reinfusion

    CPT-38242-ADOPTIVE-LYMPHOCYTE-TRANSFER

    CPT 38242: Allogeneic Lymphocyte Infusion for Recurrent Infection

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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