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    v1.0.30
    OpenPayerBilling CodesTransplantation and Post-Transplantation Cellular Infusion Procedures on the Hemic and Lymphatic SystemsCPT cpt-38242-adoptive-lymphocyte-transfer
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    CPT 38242: Allogeneic Lymphocyte Infusion for Recurrent Infection

    Medicare pays $109 on average nationally for this procedure.

    CPT code 38242 describes an allogeneic lymphocyte infusion in which lymphocytes harvested from a donor are introduced into a recipient to treat recurrent infections or lymphoproliferative disease after transplant; service type: cellular immunotherapy/allogeneic lymphocyte infusion; typical site of service: inpatient or hospital-based outpatient setting where donor cell collection and recipient infusion can be performed under specialized transplant or hematology services.

    For related coverage guidance, see recent payer policy updates: Hematology - Adzynma, Tumor Treating Fields for Pancreatic Cancer, Axicabtagene ciloleucel (Yescarta®) coverage.

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    Clinical & Coding Specifications

    Clinical Context

    A 45-year-old patient with profound lymphopenia and recurrent opportunistic infections following an allogeneic hematopoietic stem cell transplant is evaluated for adoptive lymphocyte transfer. The transplant team identifies a matched donor (usually the original stem cell donor or a closely matched related donor) who undergoes lymphocyte harvest. The procedure 38242 documents the infusion of lymphocytes from that donor into the recipient to provide passive cellular immunity and treat or prevent persistent viral or fungal infections or post-transplant lymphoproliferative disease. The workflow includes donor screening and consent, donor peripheral blood lymphocyte collection (apheresis or venipuncture harvest documented separately), infectious disease and HLA compatibility testing, pre-infusion recipient assessment, administration of pre-medications as indicated, infusion of harvested lymphocytes under monitored conditions in an outpatient infusion center or inpatient transplant unit, and post-infusion observation for infusion reactions and graft-versus-host phenomena. Documentation should include donor identification, harvest method, cell dose or volume infused, time and date of infusion, recipient pre- and post-infusion vital signs, and any adverse events.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    38240Hematopoietic progenitor cell (HPC), autologous; allogeneic peripheral blood progenitor cell collection or exchange transfusionOften performed earlier for donor cell harvest when mobilized peripheral blood stem cells are collected prior to lymphocyte isolation
    38241Hematopoietic progenitor cell (HPC), allogeneic; bone marrow harvest for transplantationAlternative donor cell source; may be performed instead of peripheral harvest
    86356Crossmatch, antibody detection (e.g., lymphocyte crossmatch)Pre-infusion laboratory compatibility testing between donor lymphocytes and recipient
    36415Collection of venous blood by venipunctureDocumentation of peripheral blood draws for infectious disease and compatibility testing prior to infusion
    96365Intravenous infusion, initial, up to 1 hourWhen infusion time and administration are billed for time-based infusion services associated with lymphocyte administration

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RC0000X
    208000000X
    2084P0800X
    1835P0018X
    246RH0600X
    261QX0203X
    251300000X
    1835I0206X

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 2

    10 rows

    PolicyPayerEffective Date
    Hematology - AdzynmaCigna2026-10-15
    Tumor Treating Fields for Pancreatic Cancerselect_health2026-10-01
    Axicabtagene ciloleucel (Yescarta®) coverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Kentucky Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Kansas Only)UnitedHealthcare2026-10-01
    Electric Tumor Treatment Field Therapy (for Idaho Only)UnitedHealthcare2026-10-01
    Brexucabtagene autoleucel (Tecartus) CoverageBaylor Scott & White Health Plan2026-10-01
    Electric Tumor Treatment Field Therapy (for Pennsylvania Only)UnitedHealthcare2026-10-01
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Factor VIII ProductsCigna2026-09-15

    Related Codes

    CPT-38240-DONOR-HEMATOPOIETIC-PROGENITOR-CELL-INFUSION

    CPT 38240: Allogeneic Hematopoietic Progenitor Cell Transplantation

    CPT-38241-AUTOLOGOUS-HEMATOPOIETIC-PROGENITOR-CELL-REINFUSION

    CPT 38241: Autologous Hematopoietic Progenitor Cell Reinfusion

    CPT-38243-DONOR-DERIVED-HEMATOPOIETIC-PROGENITOR-CELL-INFUSION

    CPT 38243: Infusion of Donor-Derived Hematopoietic Progenitor Cells

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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