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    OpenPayerBilling CodesAmputation Procedures on the Femur (Thigh Region) and Knee JointCPT cpt-27594-high-femoral-amputation-secondary-closure
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    CPT 27594: Transfemoral (Above-Knee) Amputation with Secondary Closure

    Medicare pays $485 on average nationally for this procedure.

    CPT code 27594 describes a transfemoral (above-knee) amputation through the femur with secondary closure or scar revision, a surgical removal of the leg at the thigh performed for severe trauma, tumor, or uncontrolled infection; service type: major surgical amputation; typical site of service: operating room in an inpatient or outpatient surgical facility depending on clinical status and complexity.

    For related coverage guidance, see recent payer policy updates: Implants for Joint Pain, Orthopedic Applications of Stem Cell Therapy, Bone Lengthening (Distraction Osteogenesis).

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient scenario involves an adult patient with a non-salvageable lower extremity due to severe trauma, progressive limb-threatening infection (such as necrotizing soft tissue infection or uncontrolled osteomyelitis), or malignant tumor of the femur or surrounding soft tissues. The patient presents to the hospital with intractable pain, sepsis risk, nonviable distal limb, or radiographic evidence of an aggressive tumor. The multidisciplinary workflow includes preoperative assessment (history, physical, vascular and oncologic evaluation, imaging such as X-ray/MRI/CT, labs, and discussion of limb salvage versus amputation), informed consent, anesthesia evaluation, and planning of level of amputation. The operative procedure entails transfemoral amputation through the femur at the appropriate level with creation of soft tissue flaps and performance of secondary closure or scar revision as indicated. Postoperative care includes pain control (including regional anesthesia or opioids), wound care, infection surveillance, physical therapy, prosthetic consultation, and discharge planning with outpatient follow-up and prosthetic/rehabilitation coordination. Typical site of service is an inpatient hospital operating room; in select planned cases it may occur in an ambulatory surgery center if medically appropriate, but most cases are inpatient due to complexity and comorbidity. This procedure is commonly performed by orthopedic surgeons or vascular surgeons with assistance from anesthesiology and perioperative teams.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    11044Debridement; skin, subcutaneous tissue, and muscle of chest wall, abdomen, or extremities (includes removal of foreign material)May be performed preoperatively or at the time of amputation for infected soft tissue or necrosis management
    11045Debridement including bone, muscle, and cartilage; extremityPerformed when extensive debridement of infected or necrotic tissue involving deeper structures is required alongside amputation
    10120Incision and removal of foreign body, subcutaneous tissuesMay be performed for wound management or removal of infected hardware prior to or during amputation
    27690Amputation, leg, through tibia and fibula (below knee), any level; with primary closureRelated lower-level amputation code for transtibial procedures; used in cases where limb salvage is possible at a more distal level
    20926Tumor and/or cyst of bone; resection, hemicortical, including internal fixation as necessaryMay be used when tumor resection requires partial femoral resection and may precede or follow definitive transfemoral amputation
    66984Data not available in the input.Data not available in the input.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207K00000X
    208D00000X
    363L00000X
    2084P0802X
    273Y00000X
    246XC2901X
    207XS0114X
    146M00000X

    Related Payer Policy Updates

    Specialty: Orthopedics/Musculoskeletal1 / 2

    10 rows

    PolicyPayerEffective Date
    Implants for Joint PainBlue Cross Blue Shield - Rhode Island2027-03-01
    Orthopedic Applications of Stem Cell TherapyBlue Cross Blue Shield - Rhode Island2027-01-01
    Bone Lengthening (Distraction Osteogenesis)Blue Cross Blue Shield - North Dakota2027-01-01
    Orthopedic Joint Procedures of the Knee for Managed Medicaid (MMC), Health and Recovery Plan (HARP), Child Health Plus (CHP), and Essential Plan (EP) Membersuniverahealthcare2027-01-01
    Sacroiliac Joint Fusion for the Treatment of Adult Low-Back Pain Medical PolicyHealth-New-England2026-12-01
    Bone Grafts and Stabilization Devices for Spinal Defects - Medical PolicyHealth-New-England2026-12-01
    Implantable Shock Absorbers for Treatment of Knee Osteoarthritisblue cross blue shield - louisiana2026-12-01
    Autologous Chondrocyte Transplantation or Implantation Corporate Medical Policybcbsvermont2026-12-01
    Cartilage Implants for Joint Painpremerabluecrossofwashington2026-11-06
    Cartilage Implants for Joint Painpremerabluecrossofwashington2026-11-06

    Related Codes

    CPT-27590-FEMORAL-AMPUTATION-ABOVE-KNEE

    CPT 27590: Amputation of Leg Through Femur

    CPT-27591-TRANSFEMORAL-AMPUTATION-IMMEDIATE-PROSTHESIS

    CPT 27591: Transfemoral Amputation with Immediate Prosthesis

    CPT-27592-FEMORAL-TRANSSECTION-FOR-INFECTION-CONTROL

    CPT 27592: Complete Femoral Amputation (Through Femur)

    CPT-27596-FEMORAL-STUMP-SHORTENING-AMPUTATION-REVISION

    CPT 27596: Femoral Amputation Residual Limb Shortening

    CPT-27598-LOWER-LEG-DISARTICULATION-PRESERVING-FEMORAL-END

    CPT 27598: Lower Leg Amputation Separating Tibia/Fibula From Femur

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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