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    OpenPayerBilling CodesAmputation Procedures on the Femur (Thigh Region) and Knee JointCPT cpt-27592-femoral-transsection-for-infection-control
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    CPT 27592: Complete Femoral Amputation (Through Femur)

    Medicare pays $634 on average nationally for this procedure.

    CPT code 27592 describes a surgical procedure for complete amputation through the femur where the surgeon severs the thigh bone in a circumferential fashion to remove a severely infected limb; this represents a major lower extremity amputation performed as an operative surgical service, typically provided in an inpatient hospital operating room setting to control life‑threatening infection or sepsis.

    For related coverage guidance, see recent payer policy updates: Implants for Joint Pain, Orthopedic Applications of Stem Cell Therapy, Bone Lengthening (Distraction Osteogenesis).

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult with a limb-threatening, deep femoral infection (for example, necrotizing soft tissue infection, uncontrolled osteomyelitis of the femur, or severe ischemic limb with superimposed infection) who has failed aggressive medical therapy including intravenous antibiotics, repeated debridement, and revascularization attempts. The patient often presents with systemic signs of sepsis, persistent purulence, foul odor, and nonviable tissue of the thigh despite prior interventions. Initial workflow includes emergency department triage, hemodynamic stabilization, broad-spectrum IV antibiotics, imaging (radiographs, CT, or MRI) to assess bone involvement and soft tissue extent, and consultation with orthopedics, vascular surgery, and infectious disease. When limb salvage is not possible and infection threatens life, the surgical team obtains informed consent and prepares for an open femoral-level guillotine amputation under general or regional anesthesia. Perioperative steps include antibiotic redosing, tourniquet or vascular control as indicated, sterile prep, circular guillotine-level transection through soft tissue and femur with the objective of removing the infected segment, intraoperative cultures, and gross debridement. Postoperative care includes wound management, possible conversion to staged definitive amputation (flap closure or myodesis) once infection is controlled, occupational/physical therapy planning, prosthetic referral, and infectious disease-directed antimicrobial therapy based on cultures.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    11042Debridement, subcutaneous tissue (first 20 sq cm or less)May be performed prior to or during amputation to remove necrotic soft tissue or as part of serial debridements
    11043Debridement, muscle and/or fascia (first 20 sq cm or less)Used when deep soft tissue infection necessitates removal of infected muscle/fascia in the thigh before or during amputation
    11044Debridement, bone (with or without soft tissue)Applied when osteomyelitis of the femur requires direct bone debridement in conjunction with or prior to definitive amputation
    27390Amputation, hip disarticulation; not otherwise specifiedPerformed when a higher-level amputation (hip disarticulation) is required instead of a femoral-level guillotine amputation
    27595Amputation, through femur; with immediate fitting of prosthesis (as applicable)May be performed later as a definitive reconstruction/closure after initial guillotine amputation to create a functional residual limb
    99304Initial nursing facility care — per dayExample of postoperative inpatient care coding for prolonged hospitalization and complex postoperative management

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    79Modifier 79 indicates a surgical procedure performed during the postoperative global period of a prior surgery that is unrelated to the original procedure. Per AMA/CPT and CMS guidance, it is…- Use modifier 79 when the same physician (or same‑specialty physician in the same group) performs a surgical procedure during the postoperative global period of a prior surgery and the new procedure…
    58Modifier 58 (Staged or related procedure/service by the same physician during the postoperative period) indicates that a subsequent procedure performed by the same provider during the…- Use modifier 58 when the same physician/QHP performs a procedure during the postoperative/global period of an earlier procedure and the subsequent procedure is either planned or anticipated…
    63Modifier‑63 is appended to surgical CPT codes (20000–69990) when a procedure is performed on a neonate or infant weighing ≤ 4 kg (about 8.8 lbs). The AMA/AAPC definition specifies this use and notes…- Use modifier -63 only for surgical procedures in the CPT 20000–69990 series performed on a neonate or infant who weighs ≤ 4 kg at the time of the procedure; it indicates increased complexity due to…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RI0001X
    208800000X
    332800000X
    344600000X
    2279P3800X
    247100000X
    251K00000X
    261QF0050X

    Related Payer Policy Updates

    Specialty: Orthopedics/Musculoskeletal1 / 2

    10 rows

    PolicyPayerEffective Date
    Implants for Joint PainBlue Cross Blue Shield - Rhode Island2027-03-01
    Orthopedic Applications of Stem Cell TherapyBlue Cross Blue Shield - Rhode Island2027-01-01
    Bone Lengthening (Distraction Osteogenesis)Blue Cross Blue Shield - North Dakota2027-01-01
    Orthopedic Joint Procedures of the Knee for Managed Medicaid (MMC), Health and Recovery Plan (HARP), Child Health Plus (CHP), and Essential Plan (EP) Membersuniverahealthcare2027-01-01
    Sacroiliac Joint Fusion for the Treatment of Adult Low-Back Pain Medical PolicyHealth-New-England2026-12-01
    Bone Grafts and Stabilization Devices for Spinal Defects - Medical PolicyHealth-New-England2026-12-01
    Implantable Shock Absorbers for Treatment of Knee Osteoarthritisblue cross blue shield - louisiana2026-12-01
    Autologous Chondrocyte Transplantation or Implantation Corporate Medical Policybcbsvermont2026-12-01
    Cartilage Implants for Joint Painpremerabluecrossofwashington2026-11-06
    Cartilage Implants for Joint Painpremerabluecrossofwashington2026-11-06

    Related Codes

    CPT-27590-FEMORAL-AMPUTATION-ABOVE-KNEE

    CPT 27590: Amputation of Leg Through Femur

    CPT-27591-TRANSFEMORAL-AMPUTATION-IMMEDIATE-PROSTHESIS

    CPT 27591: Transfemoral Amputation with Immediate Prosthesis

    CPT-27594-HIGH-FEMORAL-AMPUTATION-SECONDARY-CLOSURE

    CPT 27594: Transfemoral (Above-Knee) Amputation with Secondary Closure

    CPT-27596-FEMORAL-STUMP-SHORTENING-AMPUTATION-REVISION

    CPT 27596: Femoral Amputation Residual Limb Shortening

    CPT-27598-LOWER-LEG-DISARTICULATION-PRESERVING-FEMORAL-END

    CPT 27598: Lower Leg Amputation Separating Tibia/Fibula From Femur

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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