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    v1.0.30
    OpenPayerBilling CodesExcision Procedures on the Neck (Soft Tissues) and ThoraxCPT cpt-21558-extensive-excision-soft-tissue-malignant-tumor-neck-thorax
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    CPT 21558: Extensive Excision of Malignant Soft Tissue Tumor, Neck/Anterior Chest

    Medicare pays $1236 on average nationally for this procedure.

    CPT code 21558 describes an extensive excision of a soft tissue malignant tumor (for example, a sarcoma) involving the neck or anterior thorax where the resection includes wide margins and surrounding structures with a tumor plus margins measuring 5 cm or greater; the service is a surgical excision for malignant soft tissue tumor typically performed in an operating room or surgical suite for patients requiring wide local or radical resection.

    For related coverage guidance, see recent payer policy updates: Surgical Procedures, Outpatient Surgical Procedures - Site of Service, Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in Adults.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 58-year-old patient presents with a rapidly enlarging, firm mass involving the anterior neck/upper thorax region. Imaging (contrast-enhanced CT and MRI) demonstrates a soft-tissue mass with suspicious extension into adjacent fascia and musculature, measuring 6.5 cm in greatest diameter. Core needle biopsy returns high-grade sarcoma. Multidisciplinary tumor board review recommends wide excision with oncologic margins of at least 2–3 cm and resection of involved adjacent structures as needed. The patient is admitted to an acute care hospital for the procedure, which is performed in the operating room under general anesthesia. The surgical team obtains wide soft-tissue margins, resects part of adjacent sternocleidomastoid muscle and prevertebral fascia, performs intraoperative frozen sections to assess margins, and places drains. Postoperative course includes inpatient pain control, wound monitoring, pathology review for margin status, coordination with medical/radiation oncology for adjuvant therapy if indicated, and discharge planning with wound care instructions and follow-up visits for oncology and surgical surveillance.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    19260Modified radical mastectomy, with or without axillary dissectionPerformed when sarcoma involves anterior chest wall or breast tissue requiring more extensive resection adjacent to 21558.
    15734Muscle, myocutaneous, or fasciocutaneous flap with microvascular anastomosisUsed for reconstruction of large soft-tissue defects created by wide excision of sarcoma in the neck/thorax region.
    38792Lymphadenectomy, radical, neckMay be performed when regional nodal assessment or clearance is clinically indicated alongside tumor excision.
    11042Debridement; subcutaneous tissue (includes epidermis and dermis)May be used for initial wound management or when staged debridement is required in the postoperative period.
    20926Tendon or muscle transfer, each tendon/muscle transferredEmployed in complex reconstructions when functional restoration is needed after resection of involved musculature.

    Related Modifiers

    13 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    50Modifier –50 (Bilateral Procedure) is appended to a CPT code when an identical procedure is performed on paired anatomical structures during the same operative session. The AMA states to add…- Use modifier -50 when the same CPT surgical, diagnostic, or radiology procedure is performed on paired anatomical structures (both sides of the body) during the same operative/session by the same…
    51Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    77Modifier 77 indicates that a previously performed procedure or service was legitimately repeated by a different physician or other qualified health care professional. The AMA’s CPT definition…- Use modifier 77 when a basic procedure or service already performed is repeated by a different physician or other qualified health care professional (for example, a second provider independently…

    Showing 1–10 of 13

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207P00000X
    207X00000X
    207K00000X
    2355S0801X
    208M00000X
    251E00000X
    208200000X
    246ZX2200X

    Related ICD-10-CM Codes

    22 rows

    ICD-10-CM CodeDescription
    C41.9Malignant neoplasm of bone and articular cartilage, unspecified
    C44.01Basal cell carcinoma of skin of lip
    C44.311Basal cell carcinoma of skin of nose
    C44.319Basal cell carcinoma of skin of other parts of face
    C47.0Malignant neoplasm of peripheral nerves of head, face and neck
    C49.0Malignant neoplasm of connective and soft tissue of head, face and neck
    C49.3Malignant neoplasm of connective and soft tissue of thorax
    C49.4Malignant neoplasm of connective and soft tissue of abdomen
    C49.5Malignant neoplasm of connective and soft tissue of pelvis
    C49.6Malignant neoplasm of connective and soft tissue of trunk, unspecified

    Showing 1–10 of 22

    Related Payer Policy Updates

    Specialty: General Surgery1 / 2

    10 rows

    PolicyPayerEffective Date
    Surgical ProceduresUnitedHealthcare2026-09-01
    Outpatient Surgical Procedures - Site of ServiceUnitedHealthcare2026-09-01
    Site of Service Ambulatory Service Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Surgical or Diagnostic Procedures in AdultsPremera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Site of Service Ambulatory Surgical Center (ASC) Select — Site of Service for Ambulatory Surgical Procedures (ASC Select)Premera Bluecross2026-09-01
    Site of Service Ambulatory Service Center (ASC) SelectPremera Bluecross2026-09-01
    Outpatient Surgical Procedures - Site of Servicesierra health and life2026-08-01
    Medical Necessity Guidelines — Inpatient Surgical CareMass General Brigham Health Plan2026-08-01
    Ambulatory Surgery Center (ASC) - Site of Care PolicyKaiser Permanente2026-08-01

    Related Codes

    CPT-21550-SOFT-TISSUE-EXCISION-NECK-CHEST-DIAGNOSTIC-BIOPSY

    CPT 21550: Excision of Soft Tissue, Neck or Chest for Diagnosis

    CPT-21552-SUBCUTANEOUS-MASS-EXCISION-NECK-CHEST-3CM-OR-GREATER

    CPT 21552: Excision of Subcutaneous Mass, Neck or Chest, 3.0 cm or Greater

    CPT-21554-NECK-ANTERIOR-THORAX-DEEP-TUMOR-EXCISION-5CM-PLUS

    CPT 21554: Excision of Subfascial Tumor ≥5 cm, Neck or Anterior Thorax

    CPT-21555-SUBCUTANEOUS-MASS-EXCISION-NECK-CHEST

    CPT 21555: Excision of Subcutaneous Mass, Neck or Anterior Chest (<3 cm)

    CPT-21556-NECK-ANTERIOR-CHEST-MUSCLE-MASS-EXCISION-LESS-THAN-5CM

    CPT 21556: Excision of Intramuscular Neck/Anterior Chest Mass (<5 cm)

    CPT-21557-EXTENSIVE-SOFT-TISSUE-EXCISION-NECK-ANTERIOR-THORAX

    CPT 21557: Extensive Excision of Soft Tissue Tumor, Neck/Anterior Thorax

    CPT-21600-PARTIAL-RIB-RESECTION

    CPT 21600: Rib Resection for Deformity or Infection

    CPT-21601-CHEST-WALL-TUMOR-EXCISION-WITH-RIB-RESECTION

    CPT 21601: Chest Wall Tumor Excision with Rib Resection

    CPT-21602-CHEST-WALL-TUMOR-RESECTION-RECONSTRUCTION-RIBS-MYOCUTANEOUS

    CPT 21602: Chest Wall Tumor Excision with Rib Reconstruction

    CPT-21603-CHEST-WALL-TUMOR-EXCISION-RECONSTRUCTION

    CPT 21603: Chest Wall Tumor Excision with Rib Reconstruction

    Showing 1–10 of 16

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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