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    OpenPayerBilling CodesMalignant neoplasms of ill-defined, other secondary and unspecified sitesICD-10-CM c76-malignant-neoplasm-other-ill-defined-sites
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    ICD-10-CM Code For Malignant Neoplasm Of Other And Ill-Defined Sites: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group C76 includes malignant neoplasms of other and ill-defined sites, covering cancers documented at anatomic locations that are not specified elsewhere or are described ambiguously in the record. These ICD-10-CM diagnosis codes are used to document clinical scenarios where the primary tumor site is unspecified or falls outside site-specific categories, capturing disease extent and organ involvement when precise localization is lacking. Accurate coding within the ICD-10-CM C76 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM C76: Malignant Neoplasm Of Other And Ill-Defined Sites Overview

    The ICD-10-CM C76 group represents malignant neoplasms located at sites that are classified as other or ill-defined when a more specific primary site cannot be assigned. These codes capture cancers that involve various body regions not covered by site-specific neoplasm codes or that are described imprecisely in documentation. Accurate coding matters for reimbursement because payers and the Centers for Medicare & Medicaid Services rely on specific diagnosis codes to determine medical necessity and appropriate payment.

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    When to Use

    Use a code from this group when clinical documentation indicates a malignant neoplasm at an anatomic site that is not specified elsewhere or is described as ill-defined and no more specific site-based code applies. These codes are appropriate when the record lacks sufficient detail to assign a site-specific malignant neoplasm code or when the tumor is reported at an uncommon or unspecified location.

    ICD-10-CM Codes

    11 rows

    ICD-10-CM CodeDescription
    C76.0Malignant neoplasm of head, face and neck
    C76.1Malignant neoplasm of thorax
    C76.2Malignant neoplasm of abdomen
    C76.3Malignant neoplasm of pelvis
    C76.40Malignant neoplasm of unspecified upper limb
    C76.41Malignant neoplasm of right upper limb
    C76.42Malignant neoplasm of left upper limb
    C76.50Malignant neoplasm of unspecified lower limb
    C76.51Malignant neoplasm of right lower limb
    C76.52Malignant neoplasm of left lower limb
    C76.8Malignant neoplasm of other specified ill-defined sites

    DRG Codes

    34 rows

    DRG CodeDescription
    011Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with MCC
    012Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with CC
    013Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy without CC/MCC
    146Ear, Nose, Mouth and Throat Malignancy with MCC
    147Ear, Nose, Mouth and Throat Malignancy with CC
    148Ear, Nose, Mouth and Throat Malignancy without CC/MCC
    180Respiratory Neoplasms with MCC
    181Respiratory Neoplasms with CC
    182Respiratory Neoplasms without CC/MCC
    374Digestive Malignancy with MCC
    375Digestive Malignancy with CC
    376Digestive Malignancy without CC/MCC
    715Other Male Reproductive System O.R. Procedures for Malignancy with CC/MCC
    716Other Male Reproductive System O.R. Procedures for Malignancy without CC/MCC
    722Malignancy, Male Reproductive System with MCC
    723Malignancy, Male Reproductive System with CC
    724Malignancy, Male Reproductive System without CC/MCC
    736Uterine and Adnexa Procedures for Ovarian or Adnexal Malignancy with MCC
    737Uterine and Adnexa Procedures for Ovarian or Adnexal Malignancy with CC
    738Uterine and Adnexa Procedures for Ovarian or Adnexal Malignancy without CC/MCC

    Showing 1–20 of 34

    Typical Clinical Scenarios

    • An elderly patient presents to the emergency department with progressive, painless swelling of the right supraclavicular region and new-onset hoarseness; imaging shows an irregular mass in the lower neck crossing anatomical boundaries, but the primary site cannot be identified on PET/CT and biopsy reveals poorly differentiated malignant cells. The acute workup and biopsy are performed because of rapidly evolving local symptoms and concern for regional metastatic disease; a code from this group is assigned to capture a malignant neoplasm located in an other or ill-defined head and neck site when a more specific primary site cannot be determined. Typical codes: C76.0, C76.8
    • A middle-aged patient with a history of treated lung cancer presents for routine oncology follow-up with newly noted pain and focal swelling in the upper back; imaging demonstrates a solitary mass involving the thoracic soft tissues and paravertebral region without clear origin from bone or lung. This chronic surveillance visit documents a malignant neoplasm of an other/ill-defined thoracic soft tissue site when the lesion cannot be confidently classified under a more specific anatomical code, so an appropriate code from this group is used. Typical codes: C76.1, C76.8
    • A hospitalized patient with advanced, widely metastatic disease is admitted for symptom control of severe abdominal pain and cachexia; cross-sectional imaging shows an ill-defined intra-abdominal soft tissue mass in the retroperitoneum encasing vessels, and biopsy is non-diagnostic for a specific primary site. As a comorbidity complicating care and guiding palliative management, a code from this group is assigned to record a malignant neoplasm of an other or ill-defined intra-abdominal site when location is vague or not attributable to a specific organ. Typical codes: C76.3, C76.8

    Related Codes

    C77-SECONDARY-AND-UNSPECIFIED-LYMPH-NODE-NEOPLASMS

    ICD-10-CM Code For Secondary And Unspecified Malignant Neoplasm Of Lymph Nodes: Group Overview

    C78-SECONDARY-MALIGNANT-NEOPLASM-RESPIRATORY-DIGESTIVE

    ICD-10-CM Code For Secondary Malignant Neoplasm Of Respiratory And Digestive Organs: Group Overview

    C79-SECONDARY-MALIGNANT-NEOPLASM

    ICD-10-CM Code For Secondary Malignant Neoplasm Of Other And Unspecified Sites: Group Overview

    C80-MALIGNANT-NEOPLASM-UNSPECIFIED

    ICD-10-CM Code For Malignant Neoplasm Without Specification Of Site: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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