ICD-10-CM Code For Other Human Herpesviruses: Group Overview

The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group B10 includes infections due to other human herpesviruses such as cytomegalovirus and Epstein-Barr virus manifestations when classified under this group and related specified herpesviral infections. These ICD-10-CM diagnosis codes are used to document clinical scenarios including acute or chronic viral infections, organ-specific involvement, and immunocompromised host complications, capturing disease severity and clinical complexity. Accurate coding within the ICD-10-CM B10 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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ICD-10-CM B10: Other Human Herpesviruses Overview

This group represents infections caused by human herpesviruses other than herpes simplex and varicella-zoster, affecting multiple body systems depending on the specific virus and clinical presentation. These diagnoses commonly involve mucocutaneous, neurological, or systemic manifestations and may target immunocompetent or immunocompromised hosts. Accurate coding matters for clinical records and reimbursement because it documents disease severity, complications, and resource use.

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ICD-10-CM Code For Other Human Herpesviruses: Group Overview

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ICD-10-CM B10: Other Human Herpesviruses Overview

When to Use

Use a code from this group when a clinician documents an infection attributable to one of the other human herpesviruses with appropriate clinical or laboratory confirmation. Select the most specific code reflecting the site of involvement, complications, and the patient's immune status when provided.

ICD-10-CM Codes

5 rows

ICD-10-CM Code	Description
B10.01	Human herpesvirus 6 encephalitis
B10.09	Other human herpesvirus encephalitis
B10.81	Human herpesvirus 6 infection
B10.82	Human herpesvirus 7 infection
B10.89	Other human herpesvirus infection

DRG Codes

12 rows

DRG Code	Description
023	Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis with MCC or Antineoplastic Implant or Epilepsy with Neurostimulator
024	Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis without MCC
097	Non-Bacterial Infection of Nervous System Except Viral Meningitis with MCC
098	Non-Bacterial Infection of Nervous System Except Viral Meningitis with CC
099	Non-Bacterial Infection of Nervous System Except Viral Meningitis without CC/MCC
606	Minor Skin Disorders with MCC
607	Minor Skin Disorders without MCC
791	Prematurity with Major Problems
793	Full Term Neonate with Major Problems
974	HIV with Major Related Condition with MCC
975	HIV with Major Related Condition with CC
976	HIV with Major Related Condition without CC/MCC

Typical Clinical Scenarios

An adult presents to urgent care with sudden onset of multiple small, painful vesicular lesions on the labia and fever one week after a new sexual partner; clinicians obtain a swab for viral PCR and start symptomatic treatment while awaiting results. A diagnosis from this group is assigned when testing or clinical presentation indicates primary or recurrent genital infection due to non–herpes simplex human herpesviruses. Typical codes: B10.01, B10.09
A middle-aged patient with HIV and low CD4 count develops progressive bilateral facial weakness and otalgia followed by vesicular eruption in the external ear canal and palate; they are admitted for intravenous antivirals and monitoring for cranial nerve involvement. Because this is an opportunistic or complicated presentation of a non–HSV human herpesvirus affecting cranial nerves in an immunocompromised host, a code from this group is used to capture the specific viral etiology. Typical codes: B10.81, B10.82
An elderly nursing home resident with recent systemic corticosteroid therapy is evaluated for new-onset ulcerative lesions on the oral mucosa and persistent low-grade fever; culture or PCR confirms infection with a non–HSV human herpesvirus, complicating her chronic comorbidities and prolonging care. When a non–HSV herpesvirus causes mucocutaneous disease that acts as a comorbidity or complication in a frail patient, one of the codes from this group is assigned to reflect the infectious contributor to the clinical course. Typical codes: B10.89

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-CM Codes

5 rows

ICD-10-CM Code	Description
B10.01	Human herpesvirus 6 encephalitis
B10.09	Other human herpesvirus encephalitis
B10.81	Human herpesvirus 6 infection
B10.82	Human herpesvirus 7 infection
B10.89	Other human herpesvirus infection

DRG Codes

12 rows

DRG Code	Description
023	Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis with MCC or Antineoplastic Implant or Epilepsy with Neurostimulator
024	Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis without MCC
097	Non-Bacterial Infection of Nervous System Except Viral Meningitis with MCC
098	Non-Bacterial Infection of Nervous System Except Viral Meningitis with CC
099	Non-Bacterial Infection of Nervous System Except Viral Meningitis without CC/MCC
606	Minor Skin Disorders with MCC
607	Minor Skin Disorders without MCC
791	Prematurity with Major Problems
793	Full Term Neonate with Major Problems
974	HIV with Major Related Condition with MCC
975	HIV with Major Related Condition with CC
976	HIV with Major Related Condition without CC/MCC

Typical Clinical Scenarios

An adult presents to urgent care with sudden onset of multiple small, painful vesicular lesions on the labia and fever one week after a new sexual partner; clinicians obtain a swab for viral PCR and start symptomatic treatment while awaiting results. A diagnosis from this group is assigned when testing or clinical presentation indicates primary or recurrent genital infection due to non–herpes simplex human herpesviruses. Typical codes: B10.01, B10.09
A middle-aged patient with HIV and low CD4 count develops progressive bilateral facial weakness and otalgia followed by vesicular eruption in the external ear canal and palate; they are admitted for intravenous antivirals and monitoring for cranial nerve involvement. Because this is an opportunistic or complicated presentation of a non–HSV human herpesvirus affecting cranial nerves in an immunocompromised host, a code from this group is used to capture the specific viral etiology. Typical codes: B10.81, B10.82
An elderly nursing home resident with recent systemic corticosteroid therapy is evaluated for new-onset ulcerative lesions on the oral mucosa and persistent low-grade fever; culture or PCR confirms infection with a non–HSV human herpesvirus, complicating her chronic comorbidities and prolonging care. When a non–HSV herpesvirus causes mucocutaneous disease that acts as a comorbidity or complication in a frail patient, one of the codes from this group is assigned to reflect the infectious contributor to the clinical course. Typical codes: B10.89

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-CM Code For Other Human Herpesviruses: Group Overview

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ICD-10-CM B10: Other Human Herpesviruses Overview

ICD-10-CM Code For Other Human Herpesviruses: Group Overview

Sign up for ICD-10-CM Code For Other Human Herpesviruses: Group Overview policy alerts

ICD-10-CM B10: Other Human Herpesviruses Overview

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Which infections are included in the ICD-10-CM B10 group?

What specific ICD-10-CM codes are in the B10 group?

How does accurate coding in the B10 group affect reimbursement?

Which DRGs may be related to diagnoses coded from the B10 group?

What clinical scenarios are documented using B10 group diagnosis codes?

References

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Which infections are included in the ICD-10-CM B10 group?

What specific ICD-10-CM codes are in the B10 group?

How does accurate coding in the B10 group affect reimbursement?

Which DRGs may be related to diagnoses coded from the B10 group?

What clinical scenarios are documented using B10 group diagnosis codes?

References