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    v1.0.31
    OpenPayerPolicy UpdatesPharmacy & Specialty DrugsWashington HCA CFTR Modulators PA | OpenPayer
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    CurrentWashington State Health Care AuthorityPolicy 45.30.00-2

    Cystic Fibrosis Agents (Oral)

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    This policy governs prior authorization and medical necessity for oral CFTR modulators used to treat cystic fibrosis under Washington Apple Health. It applies to providers requesting initial approval, transition therapy, or reauthorization for eligible Apple Health members.

    Policy Summary
    PayerWashington State Health Care Authority
    PolicyCystic Fibrosis Agents (Oral)
    Policy CodePolicy 45.30.00-2
    Change TypeMaterial revision
    Effective DateSep 1, 2025
    Next Review DateN/A
    Key ActionDocument cystic fibrosis, an eligible CFTR mutation, product-specific age requirements, baseline clinical testing, and CF specialist involvement for initial approval.
    SourceLink
    POLICY UPDATE CHANGES

    Alyftrek (vanzacaftor/tezacaftor/deutivacaftor) was added to the cystic fibrosis agents covered by the policy.

    The pediatric eye examination requirement was removed.

    The policy updated medical necessity language and minimum age indications for selected CFTR modulators.

    Trikafta granule formulations were added to the dosage and quantity limits.

    5Oral CFTR modulators addressed
    6 moInitial approval duration
    2

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    Preferred-agent failures generally required
    85%Supply depletion before Trikafta transition
    6 moMaximum age of liver function tests
    Child-Pugh CSevere hepatic impairment excluded