Medicare Advantage Part B Medical Drugs Step Therapy
Customize your policy alerts
Sign up for Bluecross Idaho Policy MP 5.01.610 alerts
Get alerted when Policy MP 5.01.610 changes without checking for updates manually.
Monitor payer policy activity
Defines preferred biologic and specialty drug products and step-therapy/preference rules for Blue Cross of Idaho Medicare Advantage Part B members; applies to providers requesting coverage for listed medical drugs under Medicare Advantage plans.
Q5165, Q5166, Q5167, and Q5171 were added as new non-preferred denosumab products in the coding section.
Q5161 and Q5162 were added as new non-preferred denosumab products earlier in the coding section.
Permanent billing code and description were added for Jobevne and J7322 description updated to include Hymovis One.
Coverage Criteria and Preferred Products
Antiangiogenic agents - bevacizumab
Preferred antiangiogenic agents (bevacizumab) are covered when ALL of the following are met:
Only preferred products are considered medically necessary unless the member has a documented contraindication, intolerance, or adverse response to all preferred products; has used all preferred products with minimal clinical response; or has been on the requested therapy within the last 365 days.
Botulinum Toxins
Preferred botulinum toxin products are covered when ALL of the following are met:
Only preferred products are considered medically necessary unless the member has a documented contraindication, intolerance, or adverse response to all preferred products; has used all preferred products with minimal clinical response; or has been on the requested therapy within the last 365 days.
Complement Inhibitors
Preferred complement inhibitors are covered when ALL of the following are met:
Only preferred products are considered medically necessary unless the member has a documented contraindication, intolerance, or adverse response to all preferred products; has used all preferred products with minimal clinical response; or has been on the requested therapy within the last 365 days.
Denosumab (osteoporosis and malignancy)
Preferred denosumab products are covered when ALL of the following are met:
Only preferred products are considered medically necessary unless the member has a documented contraindication, intolerance, or adverse response to all preferred products; has used all preferred products with minimal clinical response; or has been on the requested therapy within the last 365 days.
Only preferred products are considered medically necessary unless the member has a documented contraindication, intolerance, or adverse response to all preferred products; has used all preferred products with minimal clinical response; or has been on the requested therapy within the last 365 days.
Monoclonal antibodies - rituximab and trastuzumab
Preferred monoclonal antibody products are covered when ALL of the following are met:
Only preferred products are considered medically necessary unless the member has a documented contraindication, intolerance, or adverse response to all preferred products; has used all preferred products with minimal clinical response; or has been on the requested therapy within the last 365 days.
Only preferred products are considered medically necessary unless the member has a documented contraindication, intolerance, or adverse response to all preferred products; has used all preferred products with minimal clinical response; or has been on the requested therapy within the last 365 days.
Pegylated Neutropenia Colony Stimulating Factors (PEG-CSF)
Preferred pegylated colony stimulating factors are covered when ALL of the following are met:
Only preferred products are considered medically necessary unless the member has a documented contraindication, intolerance, or adverse response to all preferred products; has used all preferred products with minimal clinical response; or has been on the requested therapy within the last 365 days.
Pulmonary Arterial Hypertension (PAH)
Preferred pulmonary arterial hypertension (treprostinil) products are covered when ALL of the following are met:
Only preferred products are considered medically necessary unless the member has a documented contraindication, intolerance, or adverse response to all preferred products; has used all preferred products with minimal clinical response; or has been on the requested therapy within the last 365 days.
Tumor necrosis factor-alpha (TNF-alpha) inhibitors - infliximab
Preferred infliximab products are covered when ALL of the following are met:
Only preferred products are considered medically necessary unless the member has a documented contraindication, intolerance, or adverse response to all preferred products; has used all preferred products with minimal clinical response; or has been on the requested therapy within the last 365 days.
Viscosupplements (hyaluronic acid)
Preferred viscosupplements are covered when ALL of the following are met:
Only preferred products are considered medically necessary unless the member has a documented contraindication, intolerance, or adverse response to all preferred products; has used all preferred products with minimal clinical response; or has been on the requested therapy within the last 365 days.
Coverage criteria
Preferred products may be considered medically necessary; non-preferred require meeting step therapy/prior authorization criteria
Only preferred products may be considered medically necessary unless exceptions apply.
Continuation of prior therapy within past 365 days qualifies.
Applies to Medicare Advantage Part B Medical Drugs Step Therapy.
Coverage under this medical policy is contingent on the member’s specific benefit plan and related contractual terms. Member-specific benefit plan documents supersede this medical policy where differences exist; providers must verify eligibility and the applicable benefit document before requesting coverage or submitting claims.
This policy applies only to Medicare Advantage plans. All other lines of business are excluded; do not apply this policy to commercial, Medicaid, or other non‑Medicare Advantage benefit plans.
Coding tables and code inclusions in this policy are provided for general reference only. The inclusion of a code does not guarantee member coverage or provider reimbursement. Final coverage and payment determinations depend on the member‑specific benefit plan documentation, applicable legal requirements, and other policies or guidelines.
Coding and Code Tables
| 00781-3420-80 | National Drug Code listed for Treprostinil |
| 00781-3425-80 | National Drug Code listed for Treprostinil |
| 00781-3427-80 | National Drug Code listed for Treprostinil |
| 00781-3430-80 | National Drug Code listed for Treprostinil |
| No codes listed |
| J9355 | Injection, trastuzumab, excludes biosimilar, 10 mg |
| J9356 | Injection, trastuzumab, 10 mg and hyaluronidase-oysk |
| Q5112 | Injection, trastuzumab-dttb (Ontruzant), biosimilar, 10 mg |
| Q5113 | Injection, trastuzumab-pkrb (Herzuma), biosimilar, 10 mg |
| Q5114 | Injection, Trastuzumab-dkst (Ogivri), biosimilar, 10 mg |
| Q5116 | Injection, trastuzumab-qyyp (Trazimera), biosimilar, 10 mg |
| Q5117 | Injection, trastuzumab-anns (Kanjinti), biosimilar, 10 mg |
| Q5146 | Injection, trastuzumab-strf (hercessi), biosimilar, 10 mg |
| J3285 | Injection, treprostinil, 1 mg (for PAH) |
| J7318 | Hyaluronan or derivative, Durolane, for intra-articular injection, 1 mg |
| J7320 | Hyaluronan or derivative, GenVisc 850, for intra-articular injection, 1 mg |
| J7321 | Hyaluronan or derivative, Hyalgan, Supartz or Visco-3, for intra-articular injection |
| J7322 | Hyaluronan or derivative, Hymovis or Hymovis One, for intra-articular injection, 1 mg |
| J7323 | Hyaluronan or derivative, Euflexxa, for intra-articular injection |
| J7324 | Hyaluronan or derivative, Orthovisc, for intra-articular injection |
| J7325 | Hyaluronan or derivative, Synvisc or Synvisc-One, for intra-articular injection, 1 mg |
| J7326 | Hyaluronan or derivative, Gel-One, for intra-articular injection |
| J7327 | Hyaluronan or derivative, Monovisc, for intra-articular injection |
| J7328 | Hyaluronan or derivative, GELSYN-3, for intra-articular injection, 0.1 mg |
Provider Actions, Prior Authorization, and Step Therapy
Preferred-product prior authorization requirement
Only preferred products listed for a drug class are considered medically necessary for Blue Cross of Idaho Medicare Advantage Plan members; requests for non-preferred products require documentation of a qualifying exception (documented contraindication, intolerance, or adverse response to all preferred products; history of use of all preferred products with minimal clinical response; or the member has been on the requested therapy within the last 365 days).
- Preferred products named in each drug class (e.g., Avastin, Zirabev; Dysport, Botox; Hyalgan, Hymovis, Hymovis One, etc.) are the medically necessary choices.
- Non-preferred product approval requires meeting one of the exception criteria listed above.
Prior authorization and step therapy for non-preferred viscosupplements
Prior authorization and step therapy apply to non-preferred viscosupplement products under Medicare Advantage Part B: only preferred viscosupplements are considered medically necessary unless an exception is documented (contraindication/intolerance/adverse response to all preferred products; failure of all preferred products; or member on requested therapy within past 365 days).
- Step therapy and preservice authorization are required when these medications are administered under the member's medical benefit in outpatient settings (office, home health, home infusion, outpatient hospital and dialysis, surgical day care).
- Exceptions to the preferred requirement follow the non-preferred product criteria (see policy).
Prior authorization guidance — follow benefit documents
This policy does not prescribe a specific prior authorization submission process; providers must follow Blue Cross of Idaho benefit documents and the policy's coverage sections to determine the applicable prior authorization procedures for a given member.
- Coverage determinations and prior authorization requirements are subject to the member-specific benefit plan document.
- Identify member eligibility and the member-specific benefit plan before initiating prior authorization.
Step therapy enforcement across drug classes
The policy enforces preferred-product step therapy across multiple Medicare Advantage Part B medical drug classes: providers should prescribe preferred products first and obtain prior authorization for non-preferred products unless an exception is met.
- Prescribe preferred product(s) for the drug class unless documented exception criteria are satisfied.
- Step edits will be applied consistent with the policy and utilization management systems.
Criteria permitting non-preferred product coverage
Non-preferred products may be covered only when one of the policy's step-therapy exception criteria is met: history of use of ALL preferred products with minimal clinical response; documented contraindication, intolerance, or adverse event(s) to ALL preferred products; or other documented medical reasons such as continuation of prior therapy within the last 365 days.
- A paid claim within the past 365 days for the requested therapy defines continuation of prior therapy.
- If preferred products lack an FDA-approved indication for the use, that may also permit non-preferred coverage per the policy.
Step therapy and product preference updates (policy history)
Policy history documents product preference and coding changes that may affect current step edits and product-preference enforcement; providers should verify current formulary/preference status before prescribing non-preferred agents.
- Recent history includes additions/removals of preferred and non-preferred products (e.g., Jobevne added as non-preferred bevacizumab; Hymovis One added as preferred viscosupplement).
- Coding updates effective 4/1/26 and 9/1/26 added several denosumab and other codes which may change step-edit behavior.
Verify member eligibility and benefit plan
Before applying this medical policy, identify member eligibility and the member-specific benefit plan; the member-specific benefit plan supersedes this medical policy when there is a conflict.
- Confirm the line of business—this policy applies to Medicare Advantage Part B only.
- Review related policies and the member's coverage terms prior to authorization or administration.
Documentation — support exceptions and prior authorization
Maintain clinical documentation per the policy's Documentation Requirements heading to support requests for non-preferred product coverage or continuation of therapy; the policy references documentation but does not list granular items in this section.
- Document prior trials, clinical response, contraindications/intolerances, and dates of prior therapy (to establish the 365‑day lookback).
- Retain records to support any prior authorization determinations.
Coding guidance note — codes are for reference only
Coding lists in the policy are provided for general reference only; inclusion of a code in the policy does not guarantee coverage or reimbursement—providers must follow member-specific benefit documentation and other applicable policies when submitting claims.
- Use the member's benefit plan and current coding guidance to determine billable codes and reimbursement.
- Policy coding tables do not replace benefit verification requirements.
Denial risk for non-preferred requests without exceptions
Requests for non-preferred products may be denied unless the member meets an allowed exception: documented contraindication/intolerance/adverse response to all preferred options; trial and inadequate response to all preferred products; or continuation of the requested therapy within the prior 365 days.
- Denial risk applies when non-preferred agents are requested without supporting documentation of these exceptions.
- Providers should include clinical rationale and evidence of prior trials when submitting authorizations.
Denial risk for non-authorized non-preferred therapy
If a provider administers a non-preferred therapy without obtaining prior authorization, Blue Cross of Idaho may deny claims for the non-authorized therapy.
- Obtain prior authorization before administering non-preferred medical-benefit drugs in applicable outpatient settings to avoid claim denials.
- This prior authorization requirement applies to all Medicare Advantage Plans.
Coverage contingent on member-specific benefit plan
Inclusion of a code in this policy's coding tables does not guarantee coverage or reimbursement; all coverage determinations are subject to the member-specific benefit plan document and other applicable policies and legal requirements.
- Verify coverage and reimbursement with the member's benefit plan before ordering or billing.
- Coding updates in the policy history (effective dates noted) may change coding options and preferences.
Initial Therapy Preference
Initial therapy
Initial therapy preference
Non-preferred product step therapy criteria apply as described in the policy.
Continuation and Ongoing Therapy
Continuation therapy exception
Continuation or ongoing therapy allowance
This is an exception to the preferred-product requirement and prevents forced switching for current users.
Continuation of prior therapy
Continuation of prior therapy — rules for maintaining current therapy without trial of preferred products
Example: new plan member or existing member with a paid claim within 365 days will not be required to switch to preferred product upon enrollment or policy update.
Step Therapy Rules and Tables
| Step | Requirement | When exception applies |
|---|---|---|
| 1 | ||
| Prescribe preferred product(s) for the drug class | ||
| Only if member has documented contraindication/intolerance/adverse response to all preferred products, has used all preferred products with minimal clinical response, or has been on the requested therapy within the last 365 days |
| Step | Requirement | Failure / coverage trigger |
|---|---|---|
| 1 | ||
| Trial and failure or intolerance of all preferred products required for coverage of a non-preferred product | ||
| History of use of ALL preferred products resulting in minimal clinical response; OR history of contraindication/intolerance/adverse events to ALL preferred products; OR continuation of prior therapy within the past 365 days; OR preferred product lacks an FDA-approved indication |
| Date | Policy history entry | Impact on step edits / preferences |
|---|---|---|
| 04/25/24 | ||
| Drug section replaced; changes effective 08/01/2024 including additions of non-preferred toxin and CSF codes | ||
| Updated preferred/non-preferred listings which may have required corresponding step edits (e.g., toxins, colony stimulating factors) |
Site of Care and Administration Settings
Preservice authorization required for outpatient medical benefit settings
When medications are administered under the member's medical benefit in outpatient settings (clinician/physician office, home health, home infusion, outpatient hospital and dialysis, or surgical day care), step therapy/preservice authorization is required.
- Clinician or physician office
- Home health care provider
- Home infusion therapy provider
- Outpatient hospital and dialysis settings
- Surgical day care
Biosimilar and Product Preference Notes
Bevacizumab (Jobevne) listed as non-preferred
Policy history lists Jobevne (bevacizumab-nwgd) as a non-preferred product added to the bevacizumab category.
Background and Scope
This policy groups multiple biologic and specialty drug classes and designates preferred products for Blue Cross of Idaho Medicare Advantage Part B members. Preferred products are considered medically necessary when prescribed for FDA‑accepted indications or as described in CMS‑approved compendia; non‑preferred products require meeting step‑therapy or prior authorization criteria unless an exception applies (for example, documented contraindication/intolerance/adverse response to all preferred options, inadequate clinical response to all preferred products, or the member has been on the requested therapy within the prior 365 days).
Definitions and Terms
Policy Revision History
Policy history may alter step therapy/product preference
Policy history documents changes to preferred and non‑preferred products across categories (e.g., toxins, infliximab, denosumab, bevacizumab) and coding updates; these history entries may affect current step edits and product preference enforcement.
Added Q5165, Q5166, Q5167, and Q5171 as new non-preferred denosumab products (coding updates effective 09/01/2026).
Added Q5161 and Q5162 as new non-preferred denosumab products (codes added effective 04/01/2026).
Updated viscosupplementation preferred products to include Hymovis One and added permanent billing code and description for Jobevne (bevacizumab-nwgd) in coding section (changes effective 04/01/2026).
Added Jobevne as a non-preferred bevacizumab product and made multiple updates to toxin, complement inhibitor, denosumab, and infliximab categories (changes effective 01/01/2026).
Updated preferred NDCs for infliximab and treprostinil, removed Monovisc and Orthovisc and added Euflexxa as preferred viscosupplement; changed preferred status for Remicade and added Infliximab and Avsola as preferred in infliximab category (changes effective 01/01/2025).
Added new code for non-preferred toxin Daxxify and a table showing FDA‑approved indications for toxins; clarified trastuzumab statements (changes effective 08/01/2024).
Policy added to prescription coverage as a new policy (Blue Cross of Idaho adopted policy effective 01/01/2024).
OpenPayer is powered by Trek Health's payer performance platform. Trek continuously ingests, validates, and normalizes Transparency in Coverage data alongside payer policies and other commercial payer data to create a structured payer intelligence foundation. OpenPayer uses this foundation to deliver personalized search results, dynamically generated policy pages, and tailored policy monitoring based on each user's payers, specialties, billing codes, and areas of interest. The same intelligence powers broader payer performance workflows, including reimbursement benchmarking, contract evaluation, payer negotiations, and financial decision-making.