Radiation Treatment for Selected Nononcologic Indications
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Defines Aetna's medical necessity, investigational determinations, and related coding for use of radiation therapy for selected non-cancer conditions (e.g., keloids, heterotopic ossification, Ledderhose disease, pterygium) and identifies devices/techniques considered investigational.
No material clinical or coverage changes in this revision.
Coverage Criteria and Determinations
Medically Necessary Indications
Covered when ALL of the following are met:
See policy statement; timing required for adjuvant RT.
Policy identifies specific high-risk features.
Policy specifies conventional therapy failure as prerequisite.
Policy states beta irradiation is medically necessary for pterygium not amenable to medical management.
Experimental / Investigational
Considered experimental and investigational:
Policy explicitly designates TRASER as experimental/investigational.
Policy explicitly designates ablative radiotherapy for arrhythmia as experimental/investigational.
Keloids — evidence-supported contexts
Keloids — clinical settings where radiotherapy (brachytherapy or electron/superficial X-ray) has been used and outcomes reported:
Multiple observational and prospective series summarized in policy.
Reported by De Cicco et al and others.
Nasal telangiectasias — TRASER
Nasal telangiectasias — TRASER device evaluations:
Policy notes preliminary findings and need for larger, well-designed studies.
Cardiac ablation (arrhythmia)
Ablative radiotherapy for cardiac arrhythmia — investigational use:
Policy summarizes early case series demonstrating large VT burden reduction but calls for further study.
Focal epilepsy
Radiotherapy for drug-resistant non-neoplastic focal epilepsy:
Policy cites systematic review and emphasizes limited quality of evidence.
Ledderhose disease
Ledderhose disease (plantar fibromatosis):
Policy summarizes observational cohort outcomes and typical dosing schemes.
Stereotactic/ablative radiotherapy delivery codes are not covered for the nononcologic indications addressed in this policy. Specifically, CPT codes 77373 (stereotactic body radiation therapy, treatment delivery, per fraction) and 77435 (stereotactic body radiation therapy, treatment management, per treatment course) are listed as not covered for the indications in this Clinical Policy Bulletin. Covered radiation delivery and brachytherapy codes (e.g., CPT 77401‑77417, 77767‑77772, 77778) remain available when the policy’s medically necessary selection criteria are met.
Evidence for radiotherapy in drug‑resistant, non‑neoplastic focal epilepsy is limited and heterogeneous. A systematic review identified small, low‑level studies (total n≈170) with an average of 58% of patients reporting no or rare seizures after radiotherapy, but the review rated the evidence as level 4 and noted that 20% of patients ultimately required subsequent surgery for complications or persistent seizures. Authors conclude that prospective randomized trials are needed before routine adoption.
This Clinical Policy Bulletin provides a partial, general description of plan or program benefits and is intended to assist with administration of benefits. It does not constitute a contract, guarantee coverage, or replace plan‑specific provisions. Coverage determinations remain subject to the terms of the member’s plan, applicable administrative rules, and any applicable prior authorization requirements.
The TRASER device (Total Reflection Amplification of Spontaneous Emission Radiation) and ablative radiotherapy for cardiac arrhythmia are considered experimental and investigational because effectiveness has not been established; use of these approaches for nasal telangiectasias or cardiac arrhythmia is therefore not supported as medically necessary by this policy.
Several preliminary reports and small series have described early outcomes for novel indications such as noninvasive cardiac radio‑ablation (single‑fraction SBRT ~25 Gy) and radiotherapy for focal epilepsy. These publications show promising reductions in arrhythmia burden and seizure frequency in selected patients, but sample sizes are small, follow‑up limited, and authors emphasize the need for larger, controlled studies before these approaches can be considered established therapies.
Coding and Dose Examples
| 77401-77417 | Radiation treatment delivery [includes beta irradiation] |
| 77767-77772 | Remote afterloading high dose rate radionuclide skin surface brachytherapy, includes basic dosimetry, when performed |
| 77778 | Interstitial radiation source application, complex, includes supervision, handling, loading of radiation source, when performed |
| 77373 | Stereotactic body radiation therapy, treatment delivery, per fraction to 1 or more lesions, including image guidance, entire course not to exceed 5 fractions [ablative radiotherapy] |
| 77435 | Stereotactic body radiation therapy, treatment management, per treatment course, to 1 or more lesions, including image guidance, entire course not to exceed 5 fractions [ablative radiotherapy] |
| TRASER | No specific code |
| L91.0 | Hypertrophic scar [keloid] |
| M08.1 | |
| M45.0-M45.9 | Ankylosing spondylitis |
| M48.00-M48.08 | Spinal stenosis |
| M72.2 | Plantar fascial fibromatosis |
| S06.0x0+-S06.9x9+ | Intracranial injury |
| I78.1 | Nevus, non-neoplastic [nasal telangiectasias] |
| I49.01-I49.9 | Other cardiac arrhythmias |
| No codes listed |
Provider Actions, Prior Authorization & Billing
Coding and Billing Guidance
Prior authorization and coding implications: Radiation delivery CPT codes (77401-77417, 77767-77772, 77778) are covered when the policy's selection/medical necessity criteria are met (e.g., keloid excision with RT within 7 days, heterotopic ossification prevention in high-risk persons, Ledderhose disease after failure of conservative therapy). When billing, include applicable CPT/HCPCS and ICD-10 codes and document the treatment intent (adjunctive post-op for keloid, prophylaxis for heterotopic ossification, or treatment for Ledderhose disease).
- Covered CPT ranges (when criteria met): 77401-77417, 77767-77772, 77778
- ICD-10 examples supporting coverage when criteria met: L91.0 (keloid), M72.2 (plantar fascial fibromatosis), M45.x (ankylosing spondylitis), S06.x (intracranial injury) for HO risk factors
- Keloid: radiation as adjunctive therapy within 7 days post-excision when keloid removal is medically necessary per CPB 0031
Prior Authorization — Case-by-Case Review
Prior authorization: case-by-case review is likely for novel or nonstandard indications (for example, radiotherapy for drug-resistant epilepsy or SBRT for cardiac arrhythmia); consult Aetna Clinical Policy Bulletin and plan provisions for any required prior authorization processes.
- Novel/nonstandard indications (e.g., cardiac arrhythmia ablation with radiotherapy, TRASER device use) will generally require individual review
- Consult applicable plan prior authorization requirements and the Aetna Clinical Policy Bulletin notes linked in the policy
Prior Authorization Requirements
Prior authorization requirements: Providers must follow the member's plan benefits and any Clinical Policy Bulletin instructions. Prior authorization may be required per plan; when in doubt, obtain pre-service review documentation to substantiate medical necessity.
- Refer to Aetna Clinical Policy Bulletin and the member's plan provisions for specific prior authorization processes
- Obtain pre-service review when required by the plan to avoid claim denials
Experimental / Not Covered Techniques
Experimental/investigational exclusions: Use of the TRASER device and ablative radiotherapy for cardiac arrhythmia are considered experimental/investigational and are not covered because effectiveness has not been established.
- TRASER (Total Reflection Amplification of Spontaneous Emission Radiation) — experimental/investigational for nasal telangiectasias
- Ablative radiotherapy for cardiac arrhythmia (e.g., SBRT for VT) — experimental/investigational; associated CPT codes for SBRT (77373, 77435) are not covered for this indication
Clinical Documentation Requirements
Documentation expectations: Clinical documentation must support the diagnosis, prior conservative treatments tried, and treatment intent. For Ledderhose disease and other benign indications, document failure of conventional therapies and rationale for radiotherapy (including prior injections, medications, or conservative measures).
- Document diagnosis with appropriate ICD-10 code and clinical findings
- Document conservative therapies attempted (e.g., tamoxifen, verapamil, steroid injections, shoe inserts, shockwave therapy) and their failure or intolerance
- For keloid RT, document timing of excision and that RT is delivered within 7 days post-excision as adjunctive therapy
Ledderhose (Plantar Fibromatosis) — Provider Actions
Ledderhose-specific provider actions: Radiation therapy may be medically necessary for plantar fibromatosis when conventional treatments have failed. Expect documentation of prior conservative measures and clear treatment intent; RT dosing/fields should be consistent with published practices (e.g., en face electrons, typical dose schemes noted in literature).
- Indication: Plantar fascial fibromatosis (Ledderhose disease) — consider RT after failure of conservative measures
- Document prior conservative and operative treatments and rationale for RT; record dose/fractionation and treatment field details in chart
Conservative Measures, Documentation & Denial Risk
Conservative measures and denial risk: Conservative treatments should be attempted for Ledderhose and other benign conditions prior to radiotherapy. There are no explicit denial triggers listed in this portion of the document beyond the listed experimental/investigational exclusions; however, failure to document prior conservative care or to meet the policy's selection criteria may increase risk of denial.
- Conservative measures examples: steroid injections, tamoxifen, verapamil, shoe inserts, extracorporeal shockwave therapy
- No explicit insurer-specific prior-authorization triggers are described in this document segment; follow plan rules and bulletin guidance
- Lack of adequate documentation of prior therapies and medical necessity is a common reason for claim denial
Administrative Notes
Administrative/provider notes: Preserve policy history and follow plan benefits and Clinical Policy Bulletin guidance for any operational questions. This section does not list additional explicit denial triggers beyond those noted above.
- Policy effective date: 2001-08-14; last review 07/27/2023; next review 06/13/2024
- Refer to Clinical Policy Bulletin Notes and plan-specific administrative procedures for submission and appeals
Background and Context
Keloids are benign dermal proliferations arising after skin injury and are notable for high recurrence after excision alone (reported recurrence rates of 45–100%). Adjuvant post‑operative radiation administered promptly after excision reduces recurrence; studies and consensus reporting suggest a biologically effective dose of at least BED ≥ 30 Gy is associated with improved prevention of keloid recurrence when delivered as adjunctive therapy within the early postoperative window.
Definitions and Key Terms
Policy Dates and Revision History
Policy became effective.
Policy was last reviewed.
Next scheduled policy review date.
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