ICD-10-PCS Code For Circulatory: Procedure Code Group Overview

The International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) code group XXE5 includes procedures performed to measure physiological function in the circulatory system. These ICD-10-PCS codes are used for inpatient documentation when a quantitative assessment of coronary artery blood flow is performed to evaluate physiological status. Accurate coding within the ICD-10-PCS XXE5 group is essential for proper inpatient reimbursement, as it captures the measurement performed and supports clinical documentation accuracy.

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Circulatory Measurement Procedure Overview

Procedures in this group involve measurement of physiological function within the circulatory system, specifically quantifying coronary artery flow using diagnostic techniques. These measurements determine the level of blood flow at a point in time and support clinical decision-making during inpatient stays. Accurate ICD-10-PCS coding for these measurement procedures is important for documenting the physiological assessment and for appropriate inpatient reimbursement.

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
X	Section	New Technology
X	Body System	Physiological Systems
E	Operation	Measurement
5	Body Part	Circulatory

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ICD-10-PCS Code For Circulatory: Procedure Code Group Overview

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Circulatory Measurement Procedure Overview

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
X	Section	New Technology
X	Body System	Physiological Systems
E	Operation	Measurement
5	Body Part	Circulatory

When to Use

Use a code from this group when a quantitative flow measurement of a coronary artery is obtained during an inpatient encounter. These codes apply when the clinical action is a measurement of physiological function rather than treatment or device placement.

ICD-10-PCS Codes

9 rows

ICD-10-PCS Code	Description
XXE5X2A	Measurement of Infection, Phenotypic Fully Automated Rapid Susceptibility Technology with Controlled Inoculum, New Technology Group 10
XXE5X38	Measurement of Infection, Whole Blood Reverse Transcription and Quantitative Real-time Polymerase Chain Reaction, New Technology Group 8
XXE5X4A	Measurement of Infection, Positive Blood Culture Small Molecule Sensor Array Technology, New Technology Group 10
XXE5X5A	Measurement of Immune Response, Whole Blood Cellular Assessment via Microfluidic Deformability, New Technology Group 10
XXE5XBB	Measurement of Infection and Immune Response, Gene Expression Testing System, New Technology Group 11
XXE5XR7	Measurement of Infection, Mechanical Initial Specimen Diversion Technique Using Active Negative Pressure, New Technology Group 7
XXE5XT7	Measurement of Intracranial Arterial Flow, Whole Blood mRNA, New Technology Group 7
XXE5XV7	Measurement of Infection, Serum/Plasma Nanoparticle Fluorescence SARS-CoV-2 Antibody Detection, New Technology Group 7
XXE5XY9	Measurement of Infection, Other Positive Blood/Isolated Colonies Bimodal Phenotypic Susceptibility Technology, New Technology Group 9

Typical Clinical Scenarios

An older patient is admitted with acute chest pain and high-risk non-ST-elevation myocardial infarction findings on troponin and ECG; during inpatient coronary angiography to evaluate for ischemia, quantitative physiologic assessment of coronary artery flow is performed to guide revascularization decisions. Typical codes: XXE5XT7.
A middle-aged patient with stable angina scheduled for inpatient elective diagnostic coronary angiography undergoes quantitative flow ratio assessment to determine physiologic significance of an intermediate coronary lesion identified on imaging, informing whether percutaneous intervention is needed during the same hospitalization. Typical codes: XXE5XT7.
A patient previously treated with coronary stenting presents with recurrent angina after several months; during readmission for evaluation of suspected in-stent restenosis, invasive measurement of coronary arterial flow is performed to quantify flow impairment and differentiate restenosis from microvascular causes. Typical codes: XXE5XT7.

Related Codes

XXE0-CENTRAL-NERVOUS-MEASUREMENT

ICD-10-PCS Code For Central Nervous: Procedure Code Group Overview

XXE2-CARDIAC-MEASUREMENT

ICD-10-PCS Code for Cardiac: Procedure Code Group Overview

XXE3-ARTERIAL-MEASUREMENT

ICD-10-PCS Code For Arterial: Procedure Code Group Overview

XXE9-NOSE-MEASUREMENT

ICD-10-PCS Code For Nose: Procedure Code Group Overview

XXEZ-PHYSIOLOGICAL-FUNCTION-DETERMINATION-PHYSIOLOGICAL-SYSTEMS

ICD-10-PCS Code For Physiological Systems: Procedure Code Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-PCS Codes

9 rows

ICD-10-PCS Code	Description
XXE5X2A	Measurement of Infection, Phenotypic Fully Automated Rapid Susceptibility Technology with Controlled Inoculum, New Technology Group 10
XXE5X38	Measurement of Infection, Whole Blood Reverse Transcription and Quantitative Real-time Polymerase Chain Reaction, New Technology Group 8
XXE5X4A	Measurement of Infection, Positive Blood Culture Small Molecule Sensor Array Technology, New Technology Group 10
XXE5X5A	Measurement of Immune Response, Whole Blood Cellular Assessment via Microfluidic Deformability, New Technology Group 10
XXE5XBB	Measurement of Infection and Immune Response, Gene Expression Testing System, New Technology Group 11
XXE5XR7	Measurement of Infection, Mechanical Initial Specimen Diversion Technique Using Active Negative Pressure, New Technology Group 7
XXE5XT7	Measurement of Intracranial Arterial Flow, Whole Blood mRNA, New Technology Group 7
XXE5XV7	Measurement of Infection, Serum/Plasma Nanoparticle Fluorescence SARS-CoV-2 Antibody Detection, New Technology Group 7
XXE5XY9	Measurement of Infection, Other Positive Blood/Isolated Colonies Bimodal Phenotypic Susceptibility Technology, New Technology Group 9

Typical Clinical Scenarios

An older patient is admitted with acute chest pain and high-risk non-ST-elevation myocardial infarction findings on troponin and ECG; during inpatient coronary angiography to evaluate for ischemia, quantitative physiologic assessment of coronary artery flow is performed to guide revascularization decisions. Typical codes: XXE5XT7.
A middle-aged patient with stable angina scheduled for inpatient elective diagnostic coronary angiography undergoes quantitative flow ratio assessment to determine physiologic significance of an intermediate coronary lesion identified on imaging, informing whether percutaneous intervention is needed during the same hospitalization. Typical codes: XXE5XT7.
A patient previously treated with coronary stenting presents with recurrent angina after several months; during readmission for evaluation of suspected in-stent restenosis, invasive measurement of coronary arterial flow is performed to quantify flow impairment and differentiate restenosis from microvascular causes. Typical codes: XXE5XT7.

Related Codes

XXE0-CENTRAL-NERVOUS-MEASUREMENT

ICD-10-PCS Code For Central Nervous: Procedure Code Group Overview

XXE2-CARDIAC-MEASUREMENT

ICD-10-PCS Code for Cardiac: Procedure Code Group Overview

XXE3-ARTERIAL-MEASUREMENT

ICD-10-PCS Code For Arterial: Procedure Code Group Overview

XXE9-NOSE-MEASUREMENT

ICD-10-PCS Code For Nose: Procedure Code Group Overview

XXEZ-PHYSIOLOGICAL-FUNCTION-DETERMINATION-PHYSIOLOGICAL-SYSTEMS

ICD-10-PCS Code For Physiological Systems: Procedure Code Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-PCS Code For Circulatory: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Circulatory: Procedure Code Group Overview policy alerts

Circulatory Measurement Procedure Overview

Code Attributes

ICD-10-PCS Code For Circulatory: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Circulatory: Procedure Code Group Overview policy alerts

Circulatory Measurement Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

Which procedures are included in the ICD-10-PCS code group XXE5?

What is the primary clinical purpose of procedures in XXE5?

How should XXE5 codes be used in inpatient documentation?

What are the code attributes defined for the XXE5 group?

Are there related DRGs listed for the XXE5 code group?

References

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

Which procedures are included in the ICD-10-PCS code group XXE5?

What is the primary clinical purpose of procedures in XXE5?

How should XXE5 codes be used in inpatient documentation?

What are the code attributes defined for the XXE5 group?

Are there related DRGs listed for the XXE5 code group?

References