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    v1.0.28
    OpenPayerBilling CodesGeneral symptoms and signsICD-10-CM r59-enlarged-lymph-nodes
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    ICD-10-CM Code For Enlarged Lymph Nodes: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group R59 includes diagnoses for enlarged lymph nodes, including regional and generalized lymphadenopathy and unspecified lymph node enlargement, covering presentations from localized to systemic lymph node enlargement. These ICD-10-CM diagnosis codes are used to document clinical findings of lymph node enlargement, capturing location, extent, and whether the finding is specified or unspecified. Accurate coding within the ICD-10-CM R59 group supports proper claim adjudication.

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    ICD-10-CM R59: Enlarged Lymph Nodes Overview

    The diagnoses in the ICD-10-CM R59 group represent enlargement of lymph nodes (lymphadenopathy) detected in various anatomic regions and as generalized lymphadenopathy. These codes target the lymphatic system and are used when enlargement is a presenting sign rather than a confirmed underlying malignant or infectious cause. Accurate coding matters for correct claim adjudication and to ensure clinical records reflect the extent and location of lymph node involvement.

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    When to Use

    Use a code from this group when the clinical documentation describes lymph node enlargement as a sign or finding and the documentation specifies the location or indicates generalized involvement. These codes are appropriate when enlargement is recorded but a definitive underlying cause, such as neoplasm or specific infection, is not coded in the same encounter.

    ICD-10-CM Codes

    3 rows

    ICD-10-CM CodeDescription
    R59.0Localized enlarged lymph nodes
    R59.1Generalized enlarged lymph nodes
    R59.9Enlarged lymph nodes, unspecified

    DRG Codes

    3 rows

    DRG CodeDescription
    814Reticuloendothelial and Immunity Disorders with MCC
    815Reticuloendothelial and Immunity Disorders with CC
    816Reticuloendothelial and Immunity Disorders without CC/MCC

    Typical Clinical Scenarios

    • A 7-year-old child presents to the pediatric clinic with a 3-day history of fever, sore throat, and tender, swollen cervical lymph nodes palpable along the anterior chain. The clinician documents localized lymphadenopathy related to an acute infectious process after examining the nodes and noting erythema and tenderness, so an enlarged lymph node diagnosis is assigned for the regional finding. Typical codes: R59.0, R59.9
    • A 62-year-old smoker with a 40-pack-year history is evaluated in an outpatient oncology clinic after noticing a painless, firm supraclavicular mass that has progressively enlarged over 6 weeks; imaging suggests an isolated enlarged lymph node suspicious for malignancy. Because the node is persistent and suspicious for neoplastic involvement, an enlarged lymph node diagnosis is used while further diagnostic workup (biopsy, imaging) is pursued. Typical codes: R59.1, R59.9
    • A 35-year-old patient with known HIV infection presents for routine care and is found to have generalized, non-tender lymph node enlargement on physical exam without acute infectious symptoms. The finding is documented as generalized lymphadenopathy as a comorbidity affecting the patient’s overall care and monitoring. Typical codes: R59.9

    Related Codes

    R50-FEVER-OF-OTHER-AND-UNKNOWN-ORIGIN

    ICD-10-CM Code For Fever Of Other And Unknown Origin: Group Overview

    R51-HEADACHE

    ICD-10-CM Code For Headache: Group Overview

    R52-PAIN-UNSPECIFIED

    ICD-10-CM Code For Pain Unspecified: Group Overview

    R53-MALAISE-AND-FATIGUE

    ICD-10-CM Code For Malaise And Fatigue: Group Overview

    R54-AGE-RELATED-PHYSICAL-DEBILITY

    ICD-10-CM Code For Age Related Physical Debility: Group Overview

    R55-SYNCOPE-AND-COLLAPSE

    ICD-10-CM Code For Syncope And Collapse: Group Overview

    R56-CONVULSIONS-NOT-ELSEWHERE-CLASSIFIED

    ICD-10-CM Code For Convulsions Not Elsewhere Classified: Group Overview

    R57-SHOCK-NOT-ELSEWHERE-CLASSIFIED

    ICD-10-CM Code For Shock Not Elsewhere Classified: Group Overview

    R58-HEMORRHAGE-NOT-ELSEWHERE-CLASSIFIED

    ICD-10-CM Code For Hemorrhage Not Elsewhere Classified: Group Overview

    R60-EDEMA-NOT-ELSEWHERE-CLASSIFIED

    ICD-10-CM Code For Edema Not Elsewhere Classified: Group Overview

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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