ICD-10-CM Code For Neurodevelopmental Disorders Related To Specific Genetic Pathogenic Variants: Group Overview

The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group QA0 includes neurodevelopmental disorders attributed to specific pathogenic genetic variants, covering conditions that impair cognitive, behavioral, communication, motor, and social development. These ICD-10-CM diagnosis codes are used to document clinical presentations, genetic etiology, severity of developmental impairment, and associated neurologic or systemic involvement. Accurate coding within the ICD-10-CM QA0 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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ICD-10-CM QA0: Neurodevelopmental Disorders Related To Specific Genetic Pathogenic Variants Overview

This group represents neurodevelopmental disorders caused by specific pathogenic genetic variants that primarily affect brain development, cognition, behavior, and neurodevelopmental function. These diagnoses target the nervous system and developmental domains across the lifespan. Accurate coding matters for appropriate claim processing and documentation of the genetic etiology influencing clinical management and resource use.

When to Use

Use codes from this group when a neurodevelopmental disorder has been attributed to a confirmed pathogenic genetic variant or when documentation explicitly links developmental impairments to a specific genetic etiology. These codes are appropriate for encounters where the genetic cause is relevant to clinical management, prognosis, or billing and where documentation supports the association.

ICD-10-CM Codes

13 rows

ICD-10-CM Code	Description
QA0.0101	SCN2A-related neurodevelopmental disorder
QA0.0102	CACNA1A-related neurodevelopmental disorder
QA0.0109	Neurodevelopmental disorder related to pathogenic variant in other ion channel gene
QA0.011	Neurodevelopmental disorders, related to pathogenic variants in glutamate receptor genes
QA0.012	Neurodevelopmental disorders, related to pathogenic variants in other receptor genes
QA0.0131	SLC6A1-related disorder
QA0.0139	Neurodevelopmental disorder, related to pathogenic variant in other transporter or solute carrier gene
QA0.0141	Syntaxin-binding protein 1-related disorder
QA0.0142	DLG4-related synaptopathy
QA0.0149	Neurodevelopmental disorder, related to pathogenic variant in other synapse related gene
QA0.0151	FOXG1 syndrome
QA0.0159	Neurodevelopmental disorder, related to other genes associated with transcription and gene expression
QA0.8	Other neurodevelopmental disorders related to pathogenic variants in other specific genes

DRG Codes

3 rows

DRG Code	Description
564	Other Musculoskeletal System and Connective Tissue Diagnoses with MCC
565	Other Musculoskeletal System and Connective Tissue Diagnoses with CC
566	Other Musculoskeletal System and Connective Tissue Diagnoses without CC/MCC

Typical Clinical Scenarios

A 6-month-old infant is brought to pediatric neurology by parents for delayed developmental milestones including poor head control, absent social smiling, and failure to meet motor milestones. Genetic testing reveals a pathogenic single-gene variant known to cause a neurodevelopmental disorder with early-onset global developmental delay; the visit documents the genetic etiology as the primary diagnosis guiding prognosis and family counseling. Typical codes: QA0.0101, QA0.0109
A school-age child with known intellectual disability and refractory epilepsy presents for a routine multidisciplinary clinic visit to assess ongoing cognitive decline and optimize supportive therapies. The child’s established genetic pathogenic variant is recorded as the underlying cause of the neurodevelopmental disorder and coexisting neurologic complications are managed as sequelae of that genetic diagnosis. Typical codes: QA0.011, QA0.0139
An adult with a previously undiagnosed neurodevelopmental disorder is hospitalized after an acute behavioral crisis and aggression; inpatient evaluation, including chromosomal microarray and targeted sequencing, identifies a pathogenic variant explaining lifelong cognitive impairment and recent psychiatric manifestations. The genetic diagnosis is assigned to explain the chronic neurodevelopmental condition and to inform discharge planning and referral to specialized services. Typical codes: QA0.0142, QA0.8

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-CM Codes

13 rows

ICD-10-CM Code	Description
QA0.0101	SCN2A-related neurodevelopmental disorder
QA0.0102	CACNA1A-related neurodevelopmental disorder
QA0.0109	Neurodevelopmental disorder related to pathogenic variant in other ion channel gene
QA0.011	Neurodevelopmental disorders, related to pathogenic variants in glutamate receptor genes
QA0.012	Neurodevelopmental disorders, related to pathogenic variants in other receptor genes
QA0.0131	SLC6A1-related disorder
QA0.0139	Neurodevelopmental disorder, related to pathogenic variant in other transporter or solute carrier gene
QA0.0141	Syntaxin-binding protein 1-related disorder
QA0.0142	DLG4-related synaptopathy
QA0.0149	Neurodevelopmental disorder, related to pathogenic variant in other synapse related gene
QA0.0151	FOXG1 syndrome
QA0.0159	Neurodevelopmental disorder, related to other genes associated with transcription and gene expression
QA0.8	Other neurodevelopmental disorders related to pathogenic variants in other specific genes

DRG Codes

3 rows

DRG Code	Description
564	Other Musculoskeletal System and Connective Tissue Diagnoses with MCC
565	Other Musculoskeletal System and Connective Tissue Diagnoses with CC
566	Other Musculoskeletal System and Connective Tissue Diagnoses without CC/MCC

Typical Clinical Scenarios

A 6-month-old infant is brought to pediatric neurology by parents for delayed developmental milestones including poor head control, absent social smiling, and failure to meet motor milestones. Genetic testing reveals a pathogenic single-gene variant known to cause a neurodevelopmental disorder with early-onset global developmental delay; the visit documents the genetic etiology as the primary diagnosis guiding prognosis and family counseling. Typical codes: QA0.0101, QA0.0109
A school-age child with known intellectual disability and refractory epilepsy presents for a routine multidisciplinary clinic visit to assess ongoing cognitive decline and optimize supportive therapies. The child’s established genetic pathogenic variant is recorded as the underlying cause of the neurodevelopmental disorder and coexisting neurologic complications are managed as sequelae of that genetic diagnosis. Typical codes: QA0.011, QA0.0139
An adult with a previously undiagnosed neurodevelopmental disorder is hospitalized after an acute behavioral crisis and aggression; inpatient evaluation, including chromosomal microarray and targeted sequencing, identifies a pathogenic variant explaining lifelong cognitive impairment and recent psychiatric manifestations. The genetic diagnosis is assigned to explain the chronic neurodevelopmental condition and to inform discharge planning and referral to specialized services. Typical codes: QA0.0142, QA0.8

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-CM Code For Neurodevelopmental Disorders Related To Specific Genetic Pathogenic Variants: Group Overview

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ICD-10-CM QA0: Neurodevelopmental Disorders Related To Specific Genetic Pathogenic Variants Overview

ICD-10-CM Code For Neurodevelopmental Disorders Related To Specific Genetic Pathogenic Variants: Group Overview

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ICD-10-CM QA0: Neurodevelopmental Disorders Related To Specific Genetic Pathogenic Variants Overview

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Which disorders are included in the ICD-10-CM QA0 group?

How does coding within the QA0 group support clinical documentation and claims?

What specific genes or gene categories are represented by `QA0.0101` through `QA0.0159`?

Are there related DRGs to consider when billing for QA0-coded diagnoses?

What clinical domains do QA0 diagnoses primarily affect?

References

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Which disorders are included in the ICD-10-CM QA0 group?

How does coding within the QA0 group support clinical documentation and claims?

What specific genes or gene categories are represented by `QA0.0101` through `QA0.0159`?

Are there related DRGs to consider when billing for QA0-coded diagnoses?

What clinical domains do QA0 diagnoses primarily affect?

References