ICD-10-CM Code For Disorders Resulting From Impaired Renal Tubular Function: Group Overview

The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group N25 includes disorders resulting from impaired renal tubular function, such as renal tubular acidosis and other tubular transport defects that affect electrolyte and acid-base balance. These ICD-10-CM diagnosis codes are used to document clinical scenarios involving tubular dysfunction, capturing disease severity, organ involvement, or clinical complexity relevant to this group. Accurate coding within the ICD-10-CM N25 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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ICD-10-CM N25: Disorders Resulting From Impaired Renal Tubular Function Overview

The ICD-10-CM N25 group includes disorders that arise from dysfunction of the renal tubules, affecting acid-base, electrolyte, and water handling by the kidneys. These conditions target the renal tubular system and can lead to systemic metabolic disturbances and chronic kidney disease progression. Accurate coding matters because it captures the clinical complexity and supports proper reimbursement and longitudinal patient management.

When to Use

Use a code from this group when clinical documentation indicates impaired renal tubular function confirmed by laboratory or clinical findings, such as persistent metabolic acidosis with appropriate urinary findings or documented tubular transport defects. Select the most specific code that reflects the type of tubular dysfunction and any associated complications or chronicity.

ICD-10-CM Codes

5 rows

ICD-10-CM Code	Description
N25.0	Renal osteodystrophy
N25.1	Nephrogenic diabetes insipidus
N25.81	Secondary hyperparathyroidism of renal origin
N25.89	Other disorders resulting from impaired renal tubular function
N25.9	Disorder resulting from impaired renal tubular function, unspecified

DRG Codes

3 rows

DRG Code	Description
698	Other Kidney and Urinary Tract Diagnoses with MCC
699	Other Kidney and Urinary Tract Diagnoses with CC
700	Other Kidney and Urinary Tract Diagnoses without CC/MCC

Typical Clinical Scenarios

An adult presents to the emergency department with sudden onset polyuria, polydipsia, and signs of volume depletion after ingestion of a new nephrotoxic medication; laboratory tests show hypernatremia with inappropriately dilute urine and elevated serum creatinine, consistent with acute tubular dysfunction of concentrating ability. The emergency team assigns a diagnosis reflecting an acute impairment of renal tubular function affecting water handling. Typical codes: N25.0, N25.9
A pediatric patient with a history of inherited tubular disorder is followed in nephrology clinic for chronic issues including rickets, growth failure, metabolic acidosis, and ongoing electrolyte wasting despite therapy. The chronic multisystem manifestations arising from congenital tubular defects prompt assignment of a code indicating long-standing tubular dysfunction and its metabolic consequences. Typical codes: N25.1, N25.9
An adult with long-standing chronic kidney disease develops persistent hypophosphatemia and bone pain; evaluation attributes these complications to proximal tubular phosphate wasting as a comorbidity of the renal disorder. The clinician documents a specific tubular dysfunction diagnosis to capture associated metabolic bone disease and tubular phosphate loss. Typical codes: N25.81, N25.89

Related Codes

N26-UNSPECIFIED-CONTRACTED-KIDNEY

ICD-10-CM Code For Unspecified Contracted Kidney: Group Overview

N27-SMALL-KIDNEY-OF-UNKNOWN-CAUSE

ICD-10-CM Code For Small Kidney Of Unknown Cause: Group Overview

N28-OTHER-DISORDERS-OF-KIDNEY-AND-URETER

ICD-10-CM Code For Other Disorders Of Kidney And Ureter: Group Overview

N29-OTHER-DISORDERS-OF-KIDNEY-AND-URETER

ICD-10-CM Code For Other Disorders Of Kidney And Ureter In Diseases Classified Elsewhere: Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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When to Use

ICD-10-CM Codes

5 rows

ICD-10-CM Code	Description
N25.0	Renal osteodystrophy
N25.1	Nephrogenic diabetes insipidus
N25.81	Secondary hyperparathyroidism of renal origin
N25.89	Other disorders resulting from impaired renal tubular function
N25.9	Disorder resulting from impaired renal tubular function, unspecified

DRG Codes

3 rows

DRG Code	Description
698	Other Kidney and Urinary Tract Diagnoses with MCC
699	Other Kidney and Urinary Tract Diagnoses with CC
700	Other Kidney and Urinary Tract Diagnoses without CC/MCC

Typical Clinical Scenarios

An adult presents to the emergency department with sudden onset polyuria, polydipsia, and signs of volume depletion after ingestion of a new nephrotoxic medication; laboratory tests show hypernatremia with inappropriately dilute urine and elevated serum creatinine, consistent with acute tubular dysfunction of concentrating ability. The emergency team assigns a diagnosis reflecting an acute impairment of renal tubular function affecting water handling. Typical codes: N25.0, N25.9
A pediatric patient with a history of inherited tubular disorder is followed in nephrology clinic for chronic issues including rickets, growth failure, metabolic acidosis, and ongoing electrolyte wasting despite therapy. The chronic multisystem manifestations arising from congenital tubular defects prompt assignment of a code indicating long-standing tubular dysfunction and its metabolic consequences. Typical codes: N25.1, N25.9
An adult with long-standing chronic kidney disease develops persistent hypophosphatemia and bone pain; evaluation attributes these complications to proximal tubular phosphate wasting as a comorbidity of the renal disorder. The clinician documents a specific tubular dysfunction diagnosis to capture associated metabolic bone disease and tubular phosphate loss. Typical codes: N25.81, N25.89

Related Codes

N26-UNSPECIFIED-CONTRACTED-KIDNEY

ICD-10-CM Code For Unspecified Contracted Kidney: Group Overview

N27-SMALL-KIDNEY-OF-UNKNOWN-CAUSE

ICD-10-CM Code For Small Kidney Of Unknown Cause: Group Overview

N28-OTHER-DISORDERS-OF-KIDNEY-AND-URETER

ICD-10-CM Code For Other Disorders Of Kidney And Ureter: Group Overview

N29-OTHER-DISORDERS-OF-KIDNEY-AND-URETER

ICD-10-CM Code For Other Disorders Of Kidney And Ureter In Diseases Classified Elsewhere: Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

ICD-10-CM Code For Disorders Resulting From Impaired Renal Tubular Function: Group Overview

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ICD-10-CM N25: Disorders Resulting From Impaired Renal Tubular Function Overview

ICD-10-CM Code For Disorders Resulting From Impaired Renal Tubular Function: Group Overview

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ICD-10-CM N25: Disorders Resulting From Impaired Renal Tubular Function Overview

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which conditions are included in ICD-10-CM group `N25`?

Why is accurate coding within `N25` important for billing and clinical documentation?

How does `N25` relate to DRG assignment?

Can `N25` codes indicate disease severity or organ involvement?

Does the `N25` group cover acid-base and electrolyte disturbances?

References

When to Use

ICD-10-CM Codes

DRG Codes

Typical Clinical Scenarios

Related Codes

Which conditions are included in ICD-10-CM group `N25`?

Why is accurate coding within `N25` important for billing and clinical documentation?

How does `N25` relate to DRG assignment?

Can `N25` codes indicate disease severity or organ involvement?

Does the `N25` group cover acid-base and electrolyte disturbances?

References