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    OpenPayerBilling CodesDermatitis and eczemaICD-10-CM l27-dermatitis-due-to-substances-taken-internally
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    ICD-10-CM Code For Dermatitis Due To Substances Taken Internally: Group Overview

    The International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) code group L27 includes dermatitis caused by substances taken internally, such as drug eruptions, systemic medication reactions, and other internally sourced agents producing toxic or allergic skin responses. These ICD-10-CM diagnosis codes are used to document clinical scenarios ranging from localized maculopapular rashes to generalized exfoliative or vesiculobullous reactions, capturing severity, distribution, and systemic involvement relevant to this group. Accurate coding within the ICD-10-CM L27 group supports proper claim adjudication, complete clinical documentation, and appropriate reimbursement.

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    ICD-10-CM L27: Dermatitis Due To Substances Taken Internally Overview

    This group covers dermatitis caused by systemic medications, drugs, or other internally ingested substances affecting the skin and related integumentary structures. It targets immune-mediated or toxic cutaneous reactions and their severity, distribution, and complications. Accurate coding matters for proper clinical documentation and reimbursement because it distinguishes drug-related skin reactions from other dermatitis etiologies.

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    When to Use

    Use a code from this group when a clinician documents dermatitis as caused by a medication or other internally ingested substance and that causal relationship is established or suspected. Select the code that reflects the documented clinical presentation and severity, including any specified systemic involvement or complications.

    ICD-10-CM Codes

    5 rows

    ICD-10-CM CodeDescription
    L27.0Generalized skin eruption due to drugs and medicaments taken internally
    L27.1Localized skin eruption due to drugs and medicaments taken internally
    L27.2Dermatitis due to ingested food
    L27.8Dermatitis due to other substances taken internally
    L27.9Dermatitis due to unspecified substance taken internally

    DRG Codes

    4 rows

    DRG CodeDescription
    606Minor Skin Disorders with MCC
    607Minor Skin Disorders without MCC
    791Prematurity with Major Problems
    793Full Term Neonate with Major Problems

    Typical Clinical Scenarios

    • A middle-aged patient presents to urgent care with sudden widespread urticaria and pruritic erythematous maculopapular rash after taking a newly prescribed oral antibiotic two days earlier; symptoms began several hours after ingestion and include facial flushing and intense itching without mucosal involvement. A diagnosis from this group is assigned because the dermatitis is temporally related to an internally taken medication and represents an acute drug-related skin reaction. Typical codes: L27.0, L27.1
    • An older adult with chronic kidney disease reports recurrent eczematous eruptions and generalized pruritus that flare after starting an oral iron supplement several weeks ago; lesions are persistent despite topical emollients and are evaluated in an outpatient dermatology clinic. This scenario leads to a code from this group because the eczema-like dermatitis is attributable to a substance taken internally and is a subacute/chronic presentation requiring outpatient management. Typical codes: L27.2, L27.8
    • A hospitalized patient develops a severe widespread exfoliative and blistering dermatitis during admission after initiation of an antiepileptic medication; the skin reaction complicates the inpatient course and prompts dermatology consultation and modification of the medication regimen. A code from this group is used because the dermatitis is caused by an internally administered drug and is a significant inpatient complication/comorbidity affecting care. Typical codes: L27.1, L27.8

    Related Codes

    L20-ATOPIC-DERMATITIS

    ICD-10-CM Code For Atopic Dermatitis: Group Overview

    L21-SEBORRHEIC-DERMATITIS

    ICD-10-CM Code For Seborrheic Dermatitis: Group Overview

    L22-DIAPER-DERMATITIS

    ICD-10-CM Code For Diaper Dermatitis: Group Overview

    L23-ALLERGIC-CONTACT-DERMATITIS

    ICD-10-CM Code For Allergic Contact Dermatitis: Group Overview

    L24-IRRITANT-CONTACT-DERMATITIS

    ICD-10-CM Code For Irritant Contact Dermatitis: Group Overview

    L25-UNSPECIFIED-CONTACT-DERMATITIS

    ICD-10-CM Code For Unspecified Contact Dermatitis: Group Overview

    L26-EXFOLIATIVE-DERMATITIS

    ICD-10-CM Code For Exfoliative Dermatitis: Group Overview

    L28-LICHEN-SIMPLEX-CHRONICUS-AND-PRURIGO

    ICD-10-CM Code For Lichen Simplex Chronicus And Prurigo: Group Overview

    L29-PRURITUS

    ICD-10-CM Code For Pruritus: Group Overview

    L30-OTHER-AND-UNSPECIFIED-DERMATITIS

    ICD-10-CM Code For Other And Unspecified Dermatitis: Group Overview

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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