ICD-10-PCS Code For Naloxone: Procedure Code Group Overview

The International Classification of Diseases, Tenth Revision, Procedure Coding System (ICD-10-PCS) code group HZ85 includes procedures performed to manage medication therapy for naloxone in substance abuse treatment. These ICD-10-PCS codes are used for inpatient documentation when clinicians monitor, adjust, or otherwise manage naloxone dosing and administration during treatment for opioid overdose or dependence. Accurate coding within the ICD-10-PCS HZ85 group is essential for proper inpatient reimbursement, as it captures the medication management provided and supports clinical documentation accuracy.

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Naloxone Medication Management Procedure Overview

Procedures in this group involve medication management specifically for naloxone as part of substance abuse treatment. These actions focus on monitoring and adjusting naloxone therapy rather than targeting an anatomical body system. Accurate coding of these medication management procedures ensures inpatient records reflect the clinical management provided and supports appropriate case mix and payment.

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
H	Section	Substance Abuse Treatment
Z	Body System	None
8	Operation	Medication Management
5	Body Part	Naloxone

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ICD-10-PCS Code For Naloxone: Procedure Code Group Overview

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Naloxone Medication Management Procedure Overview

Code Attributes

Character	ICD-10-PCS Category	Code Group Details
H	Section	Substance Abuse Treatment
Z	Body System	None
8	Operation	Medication Management
5	Body Part	Naloxone

When to Use

Use a code from this group when naloxone therapy is actively managed during an inpatient stay, including dosing adjustments or monitoring of response. Do not use these codes for single-dose administration without documented management activities.

ICD-10-PCS Codes

1 rows

ICD-10-PCS Code	Description
HZ85ZZZ	Medication Management for Substance Abuse Treatment, Naloxone

Typical Clinical Scenarios

A middle-aged patient is admitted from the emergency department after reversal of an opioid overdose with naloxone in the field. During the inpatient stay the clinical team monitors the patient’s respiratory status and consciousness level and actively adjusts naloxone dosing and infusion rate to prevent recurrent respiratory depression while managing opioid withdrawal symptoms. A medication management entry is documented to reflect ongoing titration and supervision of naloxone therapy. Typical codes: HZ85ZZZ
A patient with a history of opioid dependence is admitted for medically supervised withdrawal and initiation of a naloxone-based protocol to reduce overdose risk upon discharge. During the planned inpatient stay clinicians monitor response to naloxone prophylactic dosing, assess for precipitated withdrawal, and adjust therapy as needed to optimize safety before discharge planning. The documentation reflects scheduled monitoring and dose adjustments as part of inpatient medication management. Typical codes: HZ85ZZZ
A patient previously started on naloxone infusion develops recurrent sedation and intermittent hypoventilation after a change in opioid analgesic dosing, necessitating reassessment. Inpatient clinicians alter the naloxone administration parameters, closely monitor for recurrent signs of overdose and withdrawal, and document changes to the naloxone management plan to address the complication of medication interaction and fluctuating clinical status. Typical codes: HZ85ZZZ

ICD-10-PCS Code For Nicotine Replacement: Procedure Code Group Overview

HZ81-METHADONE-MAINTENANCE-MEDICATION-MANAGEMENT

ICD-10-PCS Code For Methadone Maintenance: Procedure Code Group Overview

HZ82-LEVO-ALPHA-ACETYL-METHADOL-MEDICATION-MANAGEMENT

ICD-10-PCS Code For Levo-alpha-acetyl-methadol: Procedure Code Group Overview

HZ83-ANTABUSE-MEDICATION-MANAGEMENT

ICD-10-PCS Code for Antabuse: Procedure Code Group Overview

HZ84-NALTREXONE-MEDICATION-MANAGEMENT

ICD-10-PCS Code For Naltrexone: Procedure Code Group Overview

HZ86-CLONIDINE-MEDICATION-MANAGEMENT

ICD-10-PCS Code For Clonidine: Procedure Code Group Overview

HZ87-BUPROPION-MEDICATION-MANAGEMENT

ICD-10-PCS Code For Bupropion: Procedure Code Group Overview

HZ88-PSYCHIATRIC-MEDICATION-MEDICATION-MANAGEMENT

ICD-10-PCS Code For Psychiatric Medication: Procedure Code Group Overview

HZ89-OTHER-REPLACEMENT-MEDICATION-MEDICATION-MANAGEMENT

ICD-10-PCS Code For Other Replacement Medication: Procedure Code Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Trek Health ingests and normalizes Transparency in Coverage data and payer policy updates to give provider organizations a clear view of how commercial reimbursement behaves across markets, payers, and services. Our platform transforms raw payer disclosures into structured intelligence that supports contract evaluation, payer negotiations, and service line strategy. By combining market benchmarks with ongoing policy visibility, Trek helps teams identify variability, risk, and opportunity in commercial reimbursement. The result is faster insight, stronger negotiating positions, and more informed financial decisions.

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When to Use

ICD-10-PCS Codes

1 rows

ICD-10-PCS Code	Description
HZ85ZZZ	Medication Management for Substance Abuse Treatment, Naloxone

Typical Clinical Scenarios

A middle-aged patient is admitted from the emergency department after reversal of an opioid overdose with naloxone in the field. During the inpatient stay the clinical team monitors the patient’s respiratory status and consciousness level and actively adjusts naloxone dosing and infusion rate to prevent recurrent respiratory depression while managing opioid withdrawal symptoms. A medication management entry is documented to reflect ongoing titration and supervision of naloxone therapy. Typical codes: HZ85ZZZ
A patient with a history of opioid dependence is admitted for medically supervised withdrawal and initiation of a naloxone-based protocol to reduce overdose risk upon discharge. During the planned inpatient stay clinicians monitor response to naloxone prophylactic dosing, assess for precipitated withdrawal, and adjust therapy as needed to optimize safety before discharge planning. The documentation reflects scheduled monitoring and dose adjustments as part of inpatient medication management. Typical codes: HZ85ZZZ
A patient previously started on naloxone infusion develops recurrent sedation and intermittent hypoventilation after a change in opioid analgesic dosing, necessitating reassessment. Inpatient clinicians alter the naloxone administration parameters, closely monitor for recurrent signs of overdose and withdrawal, and document changes to the naloxone management plan to address the complication of medication interaction and fluctuating clinical status. Typical codes: HZ85ZZZ

ICD-10-PCS Code For Nicotine Replacement: Procedure Code Group Overview

HZ81-METHADONE-MAINTENANCE-MEDICATION-MANAGEMENT

ICD-10-PCS Code For Methadone Maintenance: Procedure Code Group Overview

HZ82-LEVO-ALPHA-ACETYL-METHADOL-MEDICATION-MANAGEMENT

ICD-10-PCS Code For Levo-alpha-acetyl-methadol: Procedure Code Group Overview

HZ83-ANTABUSE-MEDICATION-MANAGEMENT

ICD-10-PCS Code for Antabuse: Procedure Code Group Overview

HZ84-NALTREXONE-MEDICATION-MANAGEMENT

ICD-10-PCS Code For Naltrexone: Procedure Code Group Overview

HZ86-CLONIDINE-MEDICATION-MANAGEMENT

ICD-10-PCS Code For Clonidine: Procedure Code Group Overview

HZ87-BUPROPION-MEDICATION-MANAGEMENT

ICD-10-PCS Code For Bupropion: Procedure Code Group Overview

HZ88-PSYCHIATRIC-MEDICATION-MEDICATION-MANAGEMENT

ICD-10-PCS Code For Psychiatric Medication: Procedure Code Group Overview

HZ89-OTHER-REPLACEMENT-MEDICATION-MEDICATION-MANAGEMENT

ICD-10-PCS Code For Other Replacement Medication: Procedure Code Group Overview

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

OpenPayer

ICD-10-PCS Code For Naloxone: Procedure Code Group Overview

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Naloxone Medication Management Procedure Overview

Code Attributes

OpenPayer

ICD-10-PCS Code For Naloxone: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Naloxone: Procedure Code Group Overview policy alerts

Naloxone Medication Management Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

References

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

References

ICD-10-PCS Code For Naloxone: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Naloxone: Procedure Code Group Overview policy alerts

Naloxone Medication Management Procedure Overview

Code Attributes

ICD-10-PCS Code For Naloxone: Procedure Code Group Overview

Sign up for ICD-10-PCS Code For Naloxone: Procedure Code Group Overview policy alerts

Naloxone Medication Management Procedure Overview

Code Attributes

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

What is the purpose of the ICD-10-PCS code group HZ85?

Which specific code represents naloxone medication management in this group?

What are the code attributes for procedures in HZ85?

How does accurate coding in HZ85 affect inpatient records and payment?

Are there related DRGs listed for HZ85 codes?

References

When to Use

ICD-10-PCS Codes

Typical Clinical Scenarios

Related Codes

What is the purpose of the ICD-10-PCS code group HZ85?

Which specific code represents naloxone medication management in this group?

What are the code attributes for procedures in HZ85?

How does accurate coding in HZ85 affect inpatient records and payment?

Are there related DRGs listed for HZ85 codes?

References