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    v1.0.30
    OpenPayerBilling CodesTemporary National Codes (Non-Medicare)HCPCS hcpcs-s9351-home-anti-emetic-infusion-administrative-pharmacy-services-per-diem
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    HCPCS Level II S9351: Home Anti-Emetic Infusion Therapy, Per Diem

    HCPCS Level II code S9351 describes a per diem home infusion therapy service for continuous or intermittent anti-emetic infusion therapy that includes administrative services, professional pharmacy services, care coordination, and all necessary supplies and equipment (drugs and visits billed separately); service type: home infusion therapy administration and pharmacy support; typical site of service: patient residence/home infusion setting.

    For related coverage guidance, see recent payer policy updates: Ambulance and Medical Transport Services (Ground, Air and Water) Corporate Medical Policy, Emergency Air/Water Ambulance Services Medical Guideline, Non-Emergent Ambulance Services.

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    Clinical & Coding Specifications

    Clinical Context

    A common scenario for S9351 involves an adult oncology patient with chemotherapy-induced nausea and vomiting (CINV) uncontrolled by oral or intermittent antiemetics who requires continuous or intermittent subcutaneous or intravenous anti-emetic infusion at home. The patient typically has frequent emesis despite oral agents, orthostatic symptoms from dehydration, and a central venous catheter or peripheral IV access placed during an earlier inpatient stay or outpatient infusion center visit. A specialty pharmacy coordinates delivery of infusion pumps, tubing, and anti-emetic drug vials; a home health or infusion nurse teaches pump operation, performs initial setup and competency checks, and provides routine visits for line care and infusion troubleshooting. Professional pharmacy services include compounding, dose verification, medication counseling, 24/7 clinical support, and care coordination with the oncology team. Drugs and individual nursing visits are billed separately; S9351 reimburses the per diem administrative and supply bundle for continuous or intermittent home anti-emetic infusion therapy. Typical site of service is the patient’s residence (home infusion).

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96365Intravenous infusion, therapeutic, prophylactic, or diagnostic; initial, up to 1 hourMay be used in clinic or hospital to initiate anti-emetic infusion prior to discharge to home for S9351 per diem coverage
    96366Intravenous infusion, each additional hour (list separately in addition to code for primary infusion)Represents prolonged infusion time billed in facility/outpatient setting when infusion duration extends beyond initial hour prior to home transition
    99601Home infusion therapy services requiring per visit professional servicesMay be billed for individual home infusion nursing visits separate from the S9351 per diem administrative bundle (drugs and visits billed separately)
    36561Insertion of tunneled centrally inserted central venous catheter, without subcutaneous port or pump, age 5 years or olderProcedure that may precede home infusion therapy to provide durable venous access for continuous anti-emetic infusion
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularUsed for bolus anti-emetic injections that may accompany or substitute for infusion on specific days; billed separate from S9351
    74470Radiological supervision and interpretation, venography, extremity, single viewOccasionally performed to evaluate line complications prior to ongoing home infusion; ancillary to the home infusion workflow

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    174400000X
    163W00000X
    207RC0000X
    208000000X
    227800000X
    3747A0650X
    261Q00000X
    246YC3302X

    Related ICD-10-CM Codes

    29 rows

    ICD-10-CM CodeDescription
    A09Infectious gastroenteritis and colitis, unspecified
    C16.9Malignant neoplasm of stomach, unspecified
    C17.9Malignant neoplasm of small intestine, unspecified
    C18.9Malignant neoplasm of colon, unspecified
    C78.7Secondary malignant neoplasm of liver and intrahepatic bile duct
    C80.1Malignant (primary) neoplasm, unspecified
    D86.9Sarcoidosis, unspecified
    E86.0Dehydration
    E86.1Hypovolemia
    F50.9Eating disorder, unspecified

    Showing 1–10 of 29

    Related Payer Policy Updates

    Specialty: Emergency & Medical Transportation1 / 3

    10 rows

    PolicyPayerEffective Date
    Ambulance and Medical Transport Services (Ground, Air and Water) Corporate Medical Policybcbsvermont2026-10-01
    Emergency Air/Water Ambulance Services Medical GuidelineWPS Health Insurance2026-10-01
    Non-Emergent Ambulance ServicesConnectiCare2026-09-11
    Fixed Wing Air Ambulance TransportCigna2026-08-15
    Air AmbulanceAmbetter Georgia2026-08-01
    Ambulance Services (for New Mexico Only)UnitedHealthcare2026-08-01
    Ambulance Services (for Tennessee Only)UnitedHealthcare2026-08-01
    Clinical Policy: Air AmbulanceAmbetter Nevada2026-08-01
    Air AmbulanceCentene2026-08-01
    Clinical Policy: Air AmbulanceArizona Complete Health2026-08-01

    Related Codes

    HCPCS-LEVEL-II-S2152-SOLID-ORGAN-TRANSPLANTATION-GLOBAL-CARE

    HCPCS Level II S2152: Solid Organ Procurement and Transplantation

    HCPCS-LEVEL-II-S2266-INDUCED-ABORTION-29-TO-31-WEEKS

    HCPCS Level II S2266: Induced Abortion, 29 to 31 Weeks

    HCPCS-LEVEL-II-S3630-EOSINOPHIL-COUNT-BLOOD-DIRECT

    HCPCS Level II S3630: Eosinophil Count, Blood, Direct

    HCPCS-LEVEL-II-S4017-INCOMPLETE-ART-CYCLE-CANCELLED-PRIOR-TO-STIMULATION

    HCPCS Level II S4017: Incomplete Cycle — Cancelled Prior to Stimulation

    HCPCS-LEVEL-II-S8055-ULTRASOUND-GUIDANCE-MULTIFETAL-REDUCTION-TC

    HCPCS Level II S8055: Ultrasound Guidance for Multifetal Pregnancy Reduction

    HCPCS-LEVEL-II-S8940-EQUESTRIAN-HIPPOTHERAPY-PER-SESSION

    HCPCS Level II S8940: Equestrian/Hippotherapy, Per Session

    HCPCS-LEVEL-II-S9024-PARANASAL-SINUS-ULTRASOUND

    HCPCS Level II S9024: Paranasal Sinus Ultrasound

    HCPCS-LEVEL-II-S9366-HOME-TPN-1-2L-PER-DAY-HOME-INFUSION

    HCPCS Level II S9366: Home Infusion TPN, 1–2 L/day

    HCPCS-LEVEL-II-S9446-GROUP-PATIENT-EDUCATION-NON-PHYSICIAN

    HCPCS S9446: Patient Education, Non-Physician Provider, Group, Per Session

    HCPCS-LEVEL-II-S9451-EXERCISE-CLASS-NON-PHYSICIAN-SESSION

    HCPCS S9451: Exercise Classes, Non-Physician Provider, Per Session

    Showing 1–10 of 532

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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