Summary & Overview
HCPCS S1016: Non-PVC Intravenous Administration Set
HCPCS Level II code S1016 denotes a non-PVC intravenous administration set used when drugs are unstable in polyvinyl chloride (PVC), such as paclitaxel. This supply-level code matters nationally because it ensures appropriate identification and billing for specialized infusion disposables required for safe chemotherapy and select IV therapies. Proper coding supports clinical safety, inventory management, and accurate reimbursement for infusion services using non-PVC materials.
Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of this code's clinical purpose, typical sites of service, and the operational implications for infusion providers. The publication summarizes common modifier usage and payer considerations where available, outlines clinical context for non-PVC use, and highlights what readers should expect when documenting and charging for the administration set. Data not available in the input is noted where applicable. This national-level summary is intended for revenue cycle, oncology pharmacy, and infusion clinic stakeholders who need to align clinical supply use with billing practice.
Billing Code Overview
HCPCS Level II code S1016 describes a non-PVC intravenous administration set intended for use with medications that are not stable in polyvinyl chloride, for example paclitaxel. The code covers the administration set itself rather than the drug content.
Service Type: Infusion supply / infusion administration accessory
Typical Site of Service: Hospital infusion center, outpatient infusion clinic, physician office infusion suite, and oncology centers where intravenous chemotherapy or other IV agents requiring non-PVC materials are administered.
Clinical & Coding Specifications
Clinical Context
A patient receiving an intravenous chemotherapeutic agent that is unstable in polyvinyl chloride (PVC) tubing requires a non-PVC administration set to prevent drug adsorption, leaching of plasticizers, or loss of potency. Typical patients include adults undergoing treatment with agents such as paclitaxel for breast, ovarian, or lung malignancies. The clinical workflow begins with medication preparation in pharmacy using non-PVC compatible materials, verification by a pharmacist, and labeling. In the infusion clinic or hospital infusion center, a registered nurse selects a S1016 non-PVC IV administration set, inspects the packaging and integrity, documents lot number and use on the medication administration record, primes the line with compatible solution, connects to the central venous catheter or peripheral IV, programs the infusion pump to the prescribed rate, and monitors the patient for infusion-related reactions. Post-infusion, the nurse disposes of the set per hazardous waste procedures and documents completion of the infusion and any adverse events.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
00 | No modifier | Use when no other modifier applies to the service billed with S1016. |