HCPCS S9370: Home Intermittent Anti-Emetic Injection Therapy, Per Diem

HCPCS Level II code S9370 covers per diem administrative and professional pharmacy services, care coordination, and supplies and equipment associated with home-based intermittent anti-emetic injection therapy, with drugs and nursing visits billed separately. This code matters nationally as home infusion and supportive therapies expand for symptom management in oncology, palliative care, and other outpatient settings, affecting reimbursement workflows and care coordination across payers. Key payers addressed in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise explanation of what S9370 represents, the clinical and operational contexts for home intermittent anti-emetic injections, and what to watch for in payer coverage patterns and billing practice. The publication summarizes common modifiers and implementation considerations, highlights typical sites of service and service components, and identifies gaps where input data is not available. It also outlines implications for claims processing and documentation requirements tied to per diem administrative and pharmacy services. Data not available in the input is noted where applicable.

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Billing Code Overview

HCPCS Level II code S9370 describes home therapy, intermittent anti-emetic injection therapy; administrative services, professional pharmacy services, care coordination, and all necessary supplies and equipment (drugs and nursing visits coded separately), per diem. The primary service type is home-based supportive infusion/medication administration focused on intermittent anti-emetic injections. The typical site of service is the patients home, delivered through home health or home infusion programs. Data not available in the input.

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HCPCS S9370: Home Intermittent Anti-Emetic Injection Therapy, Per Diem

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Billing Code Overview

Clinical & Coding Specifications

Clinical Context

A typical patient is an adult oncology patient receiving outpatient home-based intermittent anti-emetic injection therapy to manage chemotherapy- or radiotherapy-induced nausea and vomiting. The patient has a prescription for parenteral anti-emetic medication administered intermittently in the home setting by a licensed infusion nurse or by a trained caregiver under professional pharmacy and care coordination oversight. Administrative services include pharmacy dispensing, coordination of nursing visits, scheduling, and supply delivery. Drugs and nursing visits are billed separately; S9370 represents the per diem administrative and professional pharmacy services for home intermittent anti-emetic injection therapy. Typical workflow: referral from oncology clinic to home infusion provider, prior authorization and medication preparation by pharmacy, scheduling of nurse visit(s), nurse arrives at patient home, documents pre‑administration assessment and administers anti-emetic injection, documents response and communicates with ordering clinician, and pharmacy handles medication reconciliation, return/ disposal of controlled substances and ongoing care coordination. Typical site of service is the patient’s residence (home) or other approved non‑facility home setting.

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`R11.0`	Nausea with vomiting	Primary symptom treated by intermittent anti-emetic injection therapy in the home.
`R11.2`	Nausea with vomiting, unspecified	Alternate code for nausea/vomiting episodes requiring parenteral anti-emetic therapy.
`C80.1`	Malignant (primary) neoplasm, unspecified site — metastatic disease	Patients with advanced malignancy often require home anti-emetic support during systemic therapy or palliative care.
`C50.9`	Malignant neoplasm of breast, unspecified	An example cancer diagnosis where chemotherapy-associated nausea may necessitate home anti-emetic injections.
`C61`	Malignant neoplasm of prostate	Another oncology diagnosis where intermittent anti-emetic therapy may be used during systemic treatment.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	Commonly used to report individual administration of an anti-emetic injection when billed separately from `S9370`.
`96413`	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug	May be reported when concurrent IV chemotherapy infusion is administered in the home; `S9370` remains the administrative per diem.
`96415`	Chemotherapy administration, each additional hour	Used when IV infusion time extends beyond initial hour during home chemotherapy administration context.
`99024`	Postoperative follow-up visit, routine postoperative care	Occasionally used for home follow-up assessment related to therapy administration when allowed by payer.
`99070`	Supplies and materials (except spectacles), provided by physician over and above those usually included with the office visit or other services	Used to bill additional supplies not included in `S9370` where payer permits; most supplies are included or billed separately per local policy.

Related Modifiers

8 rows

Modifier	Description	When to Use
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
51	Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…	- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
76	Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…	- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
82	Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…	- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
251B00000X	Case Management Agency	An organization that is responsible for providing case management services. The agency provides services which assist an individual in gaining access…
3336C0003X	Community/Retail Pharmacy	A pharmacy where pharmacists store, prepare, and dispense medicinal preparations and/or prescriptions for a local patient population in accordance wit…
367A00000X	Advanced Practice Midwife	Advanced practice midwifery encompasses the independent provision of care during pregnancy, childbirth, and the postpartum period; sexual and reproduc…
163W00000X	Registered Nurse	(1) A registered nurse is a person qualified by graduation from an accredited nursing school (depending upon schooling, a registered nurse may receive…
390200000X	Student in an Organized Health Care Education/Training Program	An individual who is enrolled in an organized health care education/training program leading to a degree, certification, registration, and/or licensur…
2355S0801X	Speech-Language Assistant	Speech, Language and Hearing Service Providers · Specialist/Technologist
111NT0100X	Thermography Chiropractor	The NUCC recommends this code not be used. Choose a more appropriate code.
364SP0809X	Adult Psychiatric/Mental Health Clinical Nurse Specialist	Physician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist

HCPCS Level II S2152: Solid Organ Transplantation Global Care

HCPCS-LEVEL-II-S2266-INDUCED-ABORTION-29-TO-31-WEEKS

HCPCS Level II S2266: Induced Abortion, 29 to 31 Weeks

HCPCS-LEVEL-II-S3630-EOSINOPHIL-COUNT-BLOOD-DIRECT

HCPCS Level II S3630: Eosinophil Count, Blood, Direct

HCPCS-LEVEL-II-S4017-INCOMPLETE-ART-CYCLE-CANCELLED-PRIOR-TO-STIMULATION

HCPCS Level II S4017: Incomplete ART Cycle, Cancelled Prior to Stimulation

HCPCS-LEVEL-II-S8055-ULTRASOUND-GUIDANCE-MULTIFETAL-REDUCTION-TC

HCPCS Level II S8055: Ultrasound Guidance for Multifetal Pregnancy Reduction, Technical Component

HCPCS-LEVEL-II-S8940-EQUESTRIAN-HIPPOTHERAPY-PER-SESSION

HCPCS Level II S8940: Equestrian/Hippotherapy, Per Session

HCPCS-LEVEL-II-S9024-PARANASAL-SINUS-ULTRASOUND

HCPCS Level II S9024: Paranasal Sinus Ultrasound

HCPCS-LEVEL-II-S9366-HOME-TPN-1-2L-PER-DAY-HOME-INFUSION

HCPCS Level II S9366: Home TPN, 1–2 L/day, Per Diem

HCPCS-LEVEL-II-S9446-GROUP-PATIENT-EDUCATION-NON-PHYSICIAN

HCPCS Level II S9446: Group Patient Education by Non-Physician Provider

HCPCS-LEVEL-II-S9451-EXERCISE-CLASS-NON-PHYSICIAN-SESSION

HCPCS Level II S9451: Exercise Classes by Non-Physician Provider, Per Session

Showing 1–10 of 532

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Clinical & Coding Specifications

Clinical Context

Related Diagnoses

ICD-10 Code	Description	Clinical Relevance
`R11.0`	Nausea with vomiting	Primary symptom treated by intermittent anti-emetic injection therapy in the home.
`R11.2`	Nausea with vomiting, unspecified	Alternate code for nausea/vomiting episodes requiring parenteral anti-emetic therapy.
`C80.1`	Malignant (primary) neoplasm, unspecified site — metastatic disease	Patients with advanced malignancy often require home anti-emetic support during systemic therapy or palliative care.
`C50.9`	Malignant neoplasm of breast, unspecified	An example cancer diagnosis where chemotherapy-associated nausea may necessitate home anti-emetic injections.
`C61`	Malignant neoplasm of prostate	Another oncology diagnosis where intermittent anti-emetic therapy may be used during systemic treatment.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	Commonly used to report individual administration of an anti-emetic injection when billed separately from `S9370`.
`96413`	Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug	May be reported when concurrent IV chemotherapy infusion is administered in the home; `S9370` remains the administrative per diem.
`96415`	Chemotherapy administration, each additional hour	Used when IV infusion time extends beyond initial hour during home chemotherapy administration context.
`99024`	Postoperative follow-up visit, routine postoperative care	Occasionally used for home follow-up assessment related to therapy administration when allowed by payer.
`99070`	Supplies and materials (except spectacles), provided by physician over and above those usually included with the office visit or other services	Used to bill additional supplies not included in `S9370` where payer permits; most supplies are included or billed separately per local policy.

Related Modifiers

8 rows

Modifier	Description	When to Use
22	Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…	- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
26	Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…	- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
51	Modifier –51 (Multiple Procedures) is used when the same provider performs multiple procedures in the same session to identify secondary, non‑exempt procedures and indicate payment reduction logic…	- Use modifier -51 when the same provider performs multiple distinct procedures during the same patient encounter: report the highest‑valued procedure first (no modifier) and append -51 to…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
59	Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…	- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
76	Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…	- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
82	Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…	- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
251B00000X	Case Management Agency	An organization that is responsible for providing case management services. The agency provides services which assist an individual in gaining access…
3336C0003X	Community/Retail Pharmacy	A pharmacy where pharmacists store, prepare, and dispense medicinal preparations and/or prescriptions for a local patient population in accordance wit…
367A00000X	Advanced Practice Midwife	Advanced practice midwifery encompasses the independent provision of care during pregnancy, childbirth, and the postpartum period; sexual and reproduc…
163W00000X	Registered Nurse	(1) A registered nurse is a person qualified by graduation from an accredited nursing school (depending upon schooling, a registered nurse may receive…
390200000X	Student in an Organized Health Care Education/Training Program	An individual who is enrolled in an organized health care education/training program leading to a degree, certification, registration, and/or licensur…
2355S0801X	Speech-Language Assistant	Speech, Language and Hearing Service Providers · Specialist/Technologist
111NT0100X	Thermography Chiropractor	The NUCC recommends this code not be used. Choose a more appropriate code.
364SP0809X	Adult Psychiatric/Mental Health Clinical Nurse Specialist	Physician Assistants & Advanced Practice Nursing Providers · Clinical Nurse Specialist

HCPCS Level II S2152: Solid Organ Transplantation Global Care

HCPCS-LEVEL-II-S2266-INDUCED-ABORTION-29-TO-31-WEEKS

HCPCS Level II S2266: Induced Abortion, 29 to 31 Weeks

HCPCS-LEVEL-II-S3630-EOSINOPHIL-COUNT-BLOOD-DIRECT

HCPCS Level II S3630: Eosinophil Count, Blood, Direct

HCPCS-LEVEL-II-S4017-INCOMPLETE-ART-CYCLE-CANCELLED-PRIOR-TO-STIMULATION

HCPCS Level II S4017: Incomplete ART Cycle, Cancelled Prior to Stimulation

HCPCS-LEVEL-II-S8055-ULTRASOUND-GUIDANCE-MULTIFETAL-REDUCTION-TC

HCPCS Level II S8055: Ultrasound Guidance for Multifetal Pregnancy Reduction, Technical Component

HCPCS-LEVEL-II-S8940-EQUESTRIAN-HIPPOTHERAPY-PER-SESSION

HCPCS Level II S8940: Equestrian/Hippotherapy, Per Session

HCPCS-LEVEL-II-S9024-PARANASAL-SINUS-ULTRASOUND

HCPCS Level II S9024: Paranasal Sinus Ultrasound

HCPCS-LEVEL-II-S9366-HOME-TPN-1-2L-PER-DAY-HOME-INFUSION

HCPCS Level II S9366: Home TPN, 1–2 L/day, Per Diem

HCPCS-LEVEL-II-S9446-GROUP-PATIENT-EDUCATION-NON-PHYSICIAN

HCPCS Level II S9446: Group Patient Education by Non-Physician Provider

HCPCS-LEVEL-II-S9451-EXERCISE-CLASS-NON-PHYSICIAN-SESSION

HCPCS Level II S9451: Exercise Classes by Non-Physician Provider, Per Session

Showing 1–10 of 532

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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HCPCS S9370: Home Intermittent Anti-Emetic Injection Therapy, Per Diem

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Billing Code Overview

OpenPayer

HCPCS S9370: Home Intermittent Anti-Emetic Injection Therapy, Per Diem

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Billing Code Overview

Clinical & Coding Specifications

Clinical Context

Related Diagnoses

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References

Clinical & Coding Specifications

Clinical Context

Related Diagnoses

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related Codes

References