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    v1.0.31
    OpenPayerBilling CodesTemporary National Codes (Non-Medicare)HCPCS hcpcs-s0148-pegylated-interferon-alfa-2b-10-mcg-injection
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    HCPCS Level II S0148: Pegylated Interferon Alfa-2b Injection, 10 mcg

    HCPCS Level II code S0148 describes the administration of an injection of pegylated interferon alfa-2b, 10 mcg, a biologic antiviral therapy typically billed for subcutaneous injection procedures; service type: therapeutic injection/biologic administration; typical site of service: outpatient clinic or physician office for injectable therapy.

    For related coverage guidance, see recent payer policy updates: Non-Emergency Facility to Facility Transfers, Non-Emergency Facility to Facility Transfers, Medical Necessity Guidelines Non-Emergency Transportation.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult with a chronic viral infection (for example, certain hepatitis B or off-label oncology indications) under specialist care who requires supervised administration of a long-acting, pegylated interferon alfa-2b injection. The patient presents to an outpatient infusion or injection clinic, specialty pharmacy clinic, or an ambulatory clinic staffed by a hematology/oncology or infectious disease provider. Prior to the visit, the provider documents indication, baseline blood counts and liver function tests, and a medication reconciliation. At the visit the nurse verifies informed consent, reviews allergies, inspects the injection site, prepares S0148 (Injection, pegylated interferon alfa-2b, 10 mcg) per manufacturer and institutional protocol, and administers subcutaneously. Observation for acute adverse reactions occurs for a brief period; the visit note documents lot number, expiration, route, dose, and injector. Subsequent follow-up visits monitor laboratory response, adverse effects (flu-like symptoms, cytopenias, thyroid dysfunction, mood changes), and dosing intervals. Billing uses S0148 for the drug product; appropriate HCPCS modifiers (for example, those indicating professional/technical circumstances, discarded drug, or service disruptions) are appended as clinically applicable.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularCommonly billed for the professional administration of a subcutaneous injection when facility billing separates drug and administration.
    36415Collection of venous blood by venipuncturePerformed before or during therapy visits for baseline and monitoring laboratory studies.
    85025Complete blood count (CBC) with automated differentialRoutine monitoring test to detect cytopenias associated with interferon therapy.
    84443Thyroid stimulating hormone (TSH) assayUsed to monitor thyroid function due to risk of interferon-induced thyroid dysfunction.
    99070Supplies and materials (e.g., bandages, syringes) used directly by providerUsed to capture billable supplies when separate from drug code billing.

    Related Modifiers

    5 rows

    ModifierDescriptionWhen to Use
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RH0000X
    208D00000X
    363L00000X
    363A00000X
    335V00000X
    164X00000X
    172M00000X
    207ZB0001X

    Related ICD-10-CM Codes

    28 rows

    ICD-10-CM CodeDescription
    B15.9Hepatitis A without hepatic coma
    B16.9Acute hepatitis B without delta-agent and without hepatic coma
    B18.1Chronic viral hepatitis B without delta-agent
    B18.2Chronic viral hepatitis C
    B20Human immunodeficiency virus [HIV] disease
    C91.00Acute lymphoblastic leukemia not having achieved remission
    C92.90Myeloid leukemia, unspecified, not having achieved remission
    D61.9Aplastic anemia, unspecified
    D70.9Neutropenia, unspecified
    E83.52Hypercalcemia

    Showing 1–10 of 28

    Related Payer Policy Updates

    Specialty: Emergency & Medical Transportation1 / 3

    10 rows

    PolicyPayerEffective Date
    Non-Emergency Facility to Facility TransfersCareSource Georgia2026-11-01
    Non-Emergency Facility to Facility Transferscaresourcegeorgia2026-11-01
    Medical Necessity Guidelines Non-Emergency TransportationMass General Brigham Health Plan2026-11-01
    Non-Emergent Transportation Medical PolicyHealth-New-England2026-11-01
    Non-Emergency Facility to Facility Transfershap_caresource_mi_coordinated_health2026-11-01
    Ambulance and Medical Transport Services (Ground, Air and Water) Corporate Medical Policybcbsvermont2026-10-01
    Emergency Air/Water Ambulance Services Medical GuidelineWPS Health Insurance2026-10-01
    Non-Emergent Ambulance ServicesConnectiCare2026-09-11
    Fixed Wing Air Ambulance TransportCigna2026-08-15
    Air AmbulanceAmbetter Georgia2026-08-01

    Related Codes

    HCPCS-LEVEL-II-S2152-SOLID-ORGAN-TRANSPLANTATION-GLOBAL-CARE

    HCPCS Level II S2152: Solid Organ Procurement and Transplantation

    HCPCS-LEVEL-II-S2266-INDUCED-ABORTION-29-TO-31-WEEKS

    HCPCS Level II S2266: Induced Abortion, 29 to 31 Weeks

    HCPCS-LEVEL-II-S3630-EOSINOPHIL-COUNT-BLOOD-DIRECT

    HCPCS Level II S3630: Eosinophil Count, Blood, Direct

    HCPCS-LEVEL-II-S4017-INCOMPLETE-ART-CYCLE-CANCELLED-PRIOR-TO-STIMULATION

    HCPCS Level II S4017: Incomplete Cycle — Cancelled Prior to Stimulation

    HCPCS-LEVEL-II-S8055-ULTRASOUND-GUIDANCE-MULTIFETAL-REDUCTION-TC

    HCPCS Level II S8055: Ultrasound Guidance for Multifetal Pregnancy Reduction

    HCPCS-LEVEL-II-S8940-EQUESTRIAN-HIPPOTHERAPY-PER-SESSION

    HCPCS Level II S8940: Equestrian/Hippotherapy, Per Session

    HCPCS-LEVEL-II-S9024-PARANASAL-SINUS-ULTRASOUND

    HCPCS Level II S9024: Paranasal Sinus Ultrasound

    HCPCS-LEVEL-II-S9366-HOME-TPN-1-2L-PER-DAY-HOME-INFUSION

    HCPCS Level II S9366: Home Infusion TPN, 1–2 L/day

    HCPCS-LEVEL-II-S9446-GROUP-PATIENT-EDUCATION-NON-PHYSICIAN

    HCPCS S9446: Patient Education, Non-Physician Provider, Group, Per Session

    HCPCS-LEVEL-II-S9451-EXERCISE-CLASS-NON-PHYSICIAN-SESSION

    HCPCS S9451: Exercise Classes, Non-Physician Provider, Per Session

    Showing 1–10 of 532

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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