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    v1.0.28
    OpenPayerBilling CodesTemporary National Codes (Non-Medicare)HCPCS hcpcs-s0013-esketamine-nasal-spray-1mg
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    HCPCS S0013: Esketamine Nasal Spray, 1 mg

    HCPCS Level II code S0013 represents esketamine nasal spray, 1 mg, used as a medication administration billing code for intranasal esketamine therapy; the service type is medication administration / drug supply and the typical site of service is outpatient clinic or behavioral health facility where supervised intranasal dosing occurs.

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    Table of contents

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    • Billing CodesCPT, HCPCS, DRG & more
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    • ModifiersCPT modifiers & usage
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    Clinical & Coding Specifications

    Clinical Context

    A 38-year-old adult with treatment-resistant major depressive disorder presents to an outpatient specialty clinic for supervised administration of intranasal esketamine. The patient has failed multiple oral antidepressant trials and meets clinical criteria for esketamine therapy under a risk evaluation and mitigation strategy (REMS) program. On arrival, nursing completes baseline vital signs, brief cognitive and dissociation scales, and confirms no recent benzodiazepine or opioid use. A prescriber (psychiatrist) documents the indication, reviews consent, and orders S0013 (esketamine, nasal spray, 1 mg) with the appropriate dose and monitoring plan.

    The medication is prepared and administered in the clinic by a registered nurse or qualified clinician. The patient self-administers the prescribed number of sprays under direct supervision; the clinician documents lot numbers, number of milligrams delivered, and any partial doses (apply modifier as appropriate). The patient remains in the clinic for at least two hours for monitoring for sedation, dissociation, blood pressure changes, and respiratory status. Post-observation documentation includes vital signs, adverse effects, counseling provided, and plan for follow-up maintenance dosing or referral. Typical visit frequency is induction (twice weekly) followed by tapering to weekly or monthly maintenance per protocol.

    Typical site of service: outpatient infusion/medication administration unit, psychiatric clinic, or ambulatory specialty center with REMS-compliant monitoring.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    99213Office or other outpatient visit for the evaluation and management of an established patient, typically 15 minutesUsed for the prescriber visit documenting indication, informed consent, and treatment planning prior to or during the esketamine visit.
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularOften used in billing for supervised drug administration services when local payer guidance maps intranasal administration to an injection/administration code (check payer rules).
    99024Postoperative follow-up visit global service (excluded when global applies)Rarely used; may apply to formal post-treatment follow-up visits outside typical per-visit reporting — use per payer policy.
    93000Electrocardiogram, routine ECG with at least 12 leads; with interpretation and reportPerformed when cardiovascular monitoring is indicated pre- or post-administration for patients with cardiac risk factors.
    99406Smoking and tobacco use cessation counseling visit, intermediate, greater than 3 minutes up to 10 minutesBehavioral counseling codes like this or depression counseling codes may be billed alongside medication management when separate, documented counseling is provided.

    Note: Specific CPT mapping and payer rules for billing S0013 may vary by insurer; confirm E/M and drug administration coding requirements with each payor.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    2084P0800XPsychiatry PhysicianA Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
    363L00000XNurse Practitioner(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
    164W00000XLicensed Practical NurseAn individual with post-high school vocational training and practical experience in the provision of nursing care at a level less than that required f…
    261QM2500XMedical Specialty Clinic/CenterAn entity, facility, or distinct part of a facility providing diagnostic, treatment, and prescriptive services related to a specific area of medical s…
    2472B0301XBiomedical Engineering TechnicianNone
    224ZR0403XDriving and Community Mobility Occupational Therapy AssistantOccupational therapy assistants contribute to the completion of an individualized occupational therapy driving and community mobility evaluation by ad…
    1835C0206XCardiology PharmacistA licensed pharmacist who has demonstrated specialized knowledge and skill in direct patient care to ensure safe and effective use of medications in p…

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    F06.31Mood disorder due to known physiological condition with depressive features
    F32.0Major depressive disorder, single episode, mild
    F32.1Major depressive disorder, single episode, moderate
    F32.2Major depressive disorder, single episode, severe without psychotic features
    F32.3Major depressive disorder, single episode, severe with psychotic features
    F32.ADepression, unspecified
    F33.0Major depressive disorder, recurrent, mild
    F33.1Major depressive disorder, recurrent, moderate
    F33.2Major depressive disorder, recurrent severe without psychotic features
    F33.3Major depressive disorder, recurrent, severe with psychotic symptoms

    Showing 1–10 of 27

    Related Codes

    HCPCS-LEVEL-II-S2152-SOLID-ORGAN-TRANSPLANTATION-GLOBAL-CARE

    HCPCS Level II S2152: Solid Organ Procurement and Transplantation

    HCPCS-LEVEL-II-S2266-INDUCED-ABORTION-29-TO-31-WEEKS

    HCPCS Level II S2266: Induced Abortion, 29 to 31 Weeks

    HCPCS-LEVEL-II-S3630-EOSINOPHIL-COUNT-BLOOD-DIRECT

    HCPCS Level II S3630: Eosinophil Count, Blood, Direct

    HCPCS-LEVEL-II-S4017-INCOMPLETE-ART-CYCLE-CANCELLED-PRIOR-TO-STIMULATION

    HCPCS Level II S4017: Incomplete Cycle — Cancelled Prior to Stimulation

    HCPCS-LEVEL-II-S8055-ULTRASOUND-GUIDANCE-MULTIFETAL-REDUCTION-TC

    HCPCS Level II S8055: Ultrasound Guidance for Multifetal Pregnancy Reduction

    HCPCS-LEVEL-II-S8940-EQUESTRIAN-HIPPOTHERAPY-PER-SESSION

    HCPCS Level II S8940: Equestrian/Hippotherapy, Per Session

    HCPCS-LEVEL-II-S9024-PARANASAL-SINUS-ULTRASOUND

    HCPCS Level II S9024: Paranasal Sinus Ultrasound

    HCPCS-LEVEL-II-S9366-HOME-TPN-1-2L-PER-DAY-HOME-INFUSION

    HCPCS Level II S9366: Home Infusion TPN, 1–2 L/day

    HCPCS-LEVEL-II-S9446-GROUP-PATIENT-EDUCATION-NON-PHYSICIAN

    HCPCS S9446: Patient Education, Non-Physician Provider, Group, Per Session

    HCPCS-LEVEL-II-S9451-EXERCISE-CLASS-NON-PHYSICIAN-SESSION

    HCPCS S9451: Exercise Classes, Non-Physician Provider, Per Session

    Showing 1–10 of 532

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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