Summary & Overview
HCPCS Level II S0073: Injection, Aztreonam 500 mg
HCPCS Level II code S0073 denotes a 500 mg injection of aztreonam, an intravenous or intramuscular monobactam antibiotic used to treat susceptible Gram-negative infections. Nationally, codes for injectable antimicrobials matter for tracking outpatient antimicrobial use, billing consistency across sites of care, and ensuring appropriate coding for pharmacy-administered drugs.
Key payers covered in this analysis include Aetna, Blue Cross Blue Shield, Cigna Health, UnitedHealthcare, and Medicare. Readers will find a concise overview of clinical context for aztreonam injections, typical sites of service where S0073 is billed, and what stakeholders monitor when evaluating utilization and reimbursement for parenteral antibiotics. The publication outlines benchmark considerations for payers, common billing scenarios, and policy-relevant items such as coding clarity and site-of-service implications.
Where specific data elements were not provided, the publication notes that information is not available in the input and focuses on operational and policy-relevant takeaways that apply nationally.
Billing Code Overview
HCPCS Level II code S0073 represents injection, aztreonam, 500 mg. This code denotes a parenteral antimicrobial administration for an individual dose of aztreonam delivered by injection.
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Service type: Drug administration / parenteral antibiotic infusion or injection
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Typical site of service: Outpatient infusion center, physician office, clinic, or other outpatient facility
Data not available in the input for associated taxonomies, ICD-10 diagnoses, and related codes.
Clinical & Coding Specifications
Clinical Context
A typical patient is an adult with a documented gram-negative infection who is allergic to penicillins and cephalosporins, requiring parenteral monobactam therapy. The patient presents to an outpatient infusion center or emergency department for administration of S0073 (injection, aztreonam, 500 mg). Prior to dosing, a clinician reviews recent cultures, renal function (serum creatinine, eGFR), and allergy history; pharmacy verifies dose and prepares the medication under sterile technique. The injection is administered intravenously or via an existing peripheral or central line by a registered nurse; observation for infusion reaction occurs for the recommended monitoring period. Documentation includes indication, dose (multiples of 500 mg as appropriate), route, lot number, and patient tolerance. Typical sites of service are hospital outpatient infusion center, physician office, emergency department, or home infusion when supported by the payer and clinical plan of care.
Coding Specifications
| Modifier | Description | When to Use |
|---|---|---|
22 | Increased procedural services | Use when required work or complexity for administering S0073 substantially exceeds typical requirements (document rationale). |