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    OpenPayerBilling CodesPathology and Laboratory ServicesHCPCS hcpcs-p9071-pathogen-reduced-frozen-single-donor-plasma
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    HCPCS P9071: Plasma (single donor), pathogen reduced, frozen, each unit

    HCPCS Level II code P9071 describes a unit of single-donor plasma that has undergone pathogen reduction and is provided frozen; the service is the supply of pathogen-reduced frozen plasma for transfusion or other clinical use, typically managed by hospital blood banks, transfusion services, or hospital-based outpatient infusion centers where blood products are stored and issued.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Antibody-Drug Conjugates.

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    Clinical & Coding Specifications

    Clinical Context

    A 62-year-old male with end-stage liver disease and active gastrointestinal bleeding is admitted to the hospital. He is coagulopathic with an elevated INR and low fibrinogen; the transfusion medicine team orders P9071 (Plasma (single donor), pathogen reduced, frozen, each unit) to support hemostasis. The blood bank issues thawed, pathogen-reduced single-donor plasma units; units are transported to the operating room for an emergent endoscopic intervention and to the intensive care unit for ongoing resuscitation. Documentation includes indication, unit lot number, pathogen-reduction method, pre- and post-transfusion coagulation results, patient consent where required, and transfusion reaction monitoring notes. Billing occurs under the hospital outpatient or inpatient billing system depending on site of care, with applicable modifiers appended for circumstances such as professional component, reduced services, or bilateral procedures when relevant.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    36430Transfusion, blood or blood components, intravenous; per unit volume non-autologousUsed to report the administration of each unit of plasma in outpatient or inpatient settings alongside billing for the plasma product P9071
    86152Coagulation studies; thrombin time or fibrinogen (Clauss)Laboratory testing used before or after plasma transfusion to assess coagulation status and response to P9071
    85300Prothrombin timeCommon pre- and post-transfusion coagulation test to document INR changes after plasma administration
    36440Injection of a non-therapeutic substance; infusion of blood products via central line, per infusionUsed when plasma is infused through a central venous catheter; documents access-specific administration
    36495Collection of blood from a patient (e.g., for transfusion reaction workup), each specimenUsed when additional blood is drawn for transfusion reaction evaluation following administration of P9071

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    80CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
    82Modifier 82 is appended to a surgical CPT code to indicate that an attending physician acted as an assistant because a qualified resident surgeon was unavailable. In teaching hospitals it documents…- When to use: Append modifier 82 in teaching-hospital settings to indicate a physician served as an assistant surgeon because a qualified resident surgeon was unavailable (includes situations where…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207P00000XEmergency Medicine PhysicianAn emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospit…
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    163W00000XRegistered Nurse(1) A registered nurse is a person qualified by graduation from an accredited nursing school (depending upon schooling, a registered nurse may receive…
    208100000XPhysical Medicine & Rehabilitation PhysicianPhysical medicine and rehabilitation, also referred to as rehabilitation medicine, is the medical specialty concerned with diagnosing, evaluating, and…
    2355A2700XAudiology AssistantSpeech, Language and Hearing Service Providers · Specialist/Technologist
    282E00000XLong Term Care HospitalLong-term care hospitals (LTCHs) furnish extended medical and rehabilitative care to individuals who are clinically complex and have multiple acute or…
    163WX0106XOccupational Health Registered NurseNursing Service Providers · Registered Nurse

    Related ICD-10-CM Codes

    24 rows

    ICD-10-CM CodeDescription
    B18.2Chronic viral hepatitis C
    C91.00Acute lymphoblastic leukemia not having achieved remission
    C92.00Acute myeloblastic leukemia, not having achieved remission
    C95.90Leukemia, unspecified not having achieved remission
    D56.1Beta thalassemia
    D61.9Aplastic anemia, unspecified
    D62Acute posthemorrhagic anemia
    D63.1Anemia in chronic kidney disease
    D64.9Anemia, unspecified
    D65Disseminated intravascular coagulation [defibrination syndrome]

    Showing 1–10 of 24

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 4

    4 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01

    Related Codes

    HCPCS-LEVEL-II-P2029-CONGO-RED-BLOOD-TEST

    HCPCS P2029: Congo red, blood

    HCPCS-P2028-CEPHALIN-FLOCCULATION-BLOOD

    HCPCS Level II P2028: Cephalin Flocculation, Blood

    HCPCS-P2031-HAIR-ANALYSIS-EXCLUDING-ARSENIC

    HCPCS P2031: Hair Analysis (Excluding Arsenic)

    HCPCS-P2033-THYMOL-TURBIDITY-BLOOD-LAB-TEST

    HCPCS P2033: Thymol Turbidity, Blood

    HCPCS-P2038-MUCOPROTEIN-BLOOD-SEROMUCOID-LAB-TEST

    HCPCS Level II P2038: Mucoprotein (Seromucoid) Blood Test

    HCPCS-P3000-SCREENING-PAP-SMEAR-TECHNICIAN-SUPERVISED

    HCPCS Level II P3000: Screening Papanicolaou Smear by Technician

    HCPCS-P3001-SCREENING-PAP-SMEAR-CERVICAL-VAGINAL

    HCPCS Level II P3001: Screening Papanicolaou Smear, Up to Three Smears

    HCPCS-P7001-QUANTITATIVE-URINE-BACTERIAL-CULTURE-SENSITIVITY

    HCPCS P7001: Urine Bacterial Culture, Quantitative with Sensitivity

    HCPCS-P9010-WHOLE-BLOOD-TRANSFUSION-PER-UNIT

    HCPCS Level II P9010: Blood (whole) for Transfusion, per Unit

    HCPCS-P9011-BLOOD-SPLIT-UNIT

    HCPCS Level II P9011: Blood, Split Unit

    Showing 1–10 of 58

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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