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    v1.0.28
    OpenPayerBilling CodesMiscellaneous Medical ServicesHCPCS hcpcs-m0244-casirivimab-imdevimab-home-administration
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    HCPCS M0244: Casirivimab and Imdevimab Home Infusion/Injection

    HCPCS Level II code M0244 describes the provision of an intravenous infusion or subcutaneous injection of casirivimab and imdevimab with included post-administration monitoring provided in the beneficiary’s home or residence (including a home made provider-based to a hospital during the COVID-19 public health emergency); service type is monoclonal antibody administration with monitoring, and the typical site of service is the patient’s home or residence where infusion or injection and subsequent observation are delivered.

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    Table of contents

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    • Billing CodesCPT, HCPCS, DRG & more
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    Clinical & Coding Specifications

    Clinical Context

    A high-risk adult patient with recent confirmed SARS-CoV-2 infection, mild-to-moderate COVID-19 symptoms, and risk factors for progression (for example age >65, immunocompromise, chronic lung disease, or obesity) receives a single-dose monoclonal antibody therapy consisting of casirivimab and imdevimab via intravenous infusion or subcutaneous injection in the patient’s home. The clinical workflow begins with a remote or ambulatory assessment by a treating clinician (telehealth or in-office) who documents symptom onset, positive COVID-19 test, and qualifying risk factors. A home infusion team from a hospital or outpatient infusion provider arranges a home visit; the medication is prepared per facility protocol, transported under appropriate cold chain conditions, and administered in the residence. The encounter includes pre-administration verification of identity and consent, baseline vital signs and oxygen saturation, administration of the monoclonal antibody by an appropriate clinician or infusion nurse, and a post-administration monitoring period (typically 60 minutes) to observe for infusion reaction or anaphylaxis. Documentation includes start and stop times, lot numbers, administered route (intravenous infusion or subcutaneous injection), and any adverse events. Billing uses M0244 to capture the infusion/injection plus post-administration monitoring delivered in the home or other residence, including instances when the beneficiary’s home was made provider-based to the hospital during the public health emergency.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96365Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hourCommonly used for separate reporting of IV infusion administration time when institutional or payer policy requires CPT coding in addition to HCPCS Level II; documents infusion administration time for the first hour.
    96366Intravenous infusion, each additional hour (List separately in addition to code for primary procedure)Used when infusion administration continues beyond the initial hour and separate hourly reporting is required.
    36415Collection of venous blood by venipuncturePerformed prior to or during the infusion for baseline labs, serologies, or monitoring.
    99214Office or other outpatient visit, established patient, moderate complexityMay be used for the clinician evaluation that precedes the home infusion when an E/M visit is billed separately.
    99406Smoking and tobacco use cessation counseling, intermediate, greater than 3 minutes up to 10 minutesIncluded as an example of ancillary counseling codes sometimes billed in outpatient settings; not typically central to this infusion encounter.

    Related Modifiers

    9 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    163WS0200XSchool Registered NurseNursing Service Providers · Registered Nurse
    246XS1301XSonography Specialist/Technologist CardiovascularA cardiovascular sonography technologist operates special equipment to create images and conduct tests of the cardiovascular system. They work with ph…
    126800000XDental AssistantAn individual who may or may not have completed an accredited dental assisting education program and who aids the dentist in providing patient care se…
    1835P1300XPsychiatric PharmacistA licensed pharmacist who has demonstrated specialized knowledge and skill in optimizing care of patients with psychiatric illness by assessing and mo…
    101YP2500XProfessional CounselorBehavioral Health & Social Service Providers · Counselor
    227900000XRegistered Respiratory TherapistA Registered Respiratory Therapist (RRT) is an advanced therapist who has passed standardized written and clinical simulation examinations administere…
    2085R0204XVascular & Interventional Radiology PhysicianA radiologist who diagnoses and treats diseases by various radiologic imaging modalities. These include fluoroscopy, digital radiography, computed tom…
    207T00000XNeurological Surgery PhysicianA neurological surgeon provides the operative and non-operative management (i.e., prevention, diagnosis, evaluation, treatment, critical care, and reh…

    Related ICD-10-CM Codes

    28 rows

    ICD-10-CM CodeDescription
    B20Human immunodeficiency virus [HIV] disease
    B97.29Other coronavirus as the cause of diseases classified elsewhere
    C34.90Malignant neoplasm of unspecified part of unspecified bronchus or lung
    D50.9Iron deficiency anemia, unspecified
    D64.9Anemia, unspecified
    E11.9Type 2 diabetes mellitus without complications
    E66.9Obesity, unspecified
    I10Essential (primary) hypertension
    J12.82Pneumonia due to coronavirus disease 2019
    J18.9Pneumonia, unspecified organism

    Showing 1–10 of 28

    Related Codes

    HCPCS-M0075-CELLULAR-THERAPY-PROCESSING-PROVISION

    HCPCS Level II M0075: Cellular Therapy

    HCPCS-M0076-PROLOTHERAPY-INJECTION-THERAPY

    HCPCS Level II M0076: Prolotherapy

    HCPCS-M0100-INTRAGASTRIC-HYPOTHERMIA-GASTRIC-FREEZING

    HCPCS Level II M0100: Intragastric Hypothermia (Gastric Freezing)

    HCPCS-M0201-IN-HOME-VACCINE-ADMINISTRATION

    HCPCS Level II M0201: In-Home Vaccine Administration

    HCPCS-M0220-TIXAGEVIMAB-CILGAVIMAB-PRE-EXPOSURE-PROPHYLAXIS

    HCPCS Level II M0220: Tixagevimab and Cilgavimab Pre-Exposure Prophylaxis

    HCPCS-M0221-TIXAGEVIMAB-CILGAVIMAB-PRE-EXPOSURE-PROPHYLAXIS-HOME-ADMINISTRATION

    HCPCS M0221: Tixagevimab and Cilgavimab Pre-Exposure Prophylaxis

    HCPCS-M0222-BEBTELOVIMAB-INTRAVENOUS-INJECTION-MONITORING

    HCPCS Level II M0222: Bebtelovimab Intravenous Injection with Monitoring

    HCPCS-M0223-BEBTELOVIMAB-INTRAVENOUS-INJECTION-HOME-MONITORING

    HCPCS M0223: Intravenous Bebtelovimab with Home Monitoring

    HCPCS-M0224-PEMIVIBART-PRE-EXPOSURE-PROPHYLAXIS-INFUSION

    HCPCS M0224: Pemivibart Intravenous Infusion for Pre-Exposure Prophylaxis

    HCPCS-M0233-TOCILIZUMAB-INFUSION-COVID19-HOSPITALIZED-ADULTS

    HCPCS Level II M0233: Tocilizumab-aazg IV Infusion, First Dose

    Showing 1–10 of 27

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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