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    v1.0.28
    OpenPayerBilling CodesMiscellaneous Medical ServicesHCPCS hcpcs-m0241-casirivimab-imdevimab-home-infusion-injection-monitoring
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    HCPCS Level II M0241: Casirivimab and Imdevimab Infusion or Injection with Home Monitoring

    HCPCS Level II code M0241 describes an intravenous infusion or subcutaneous injection of casirivimab and imdevimab that includes the infusion or injection procedure plus post-administration monitoring provided in the patient’s home or residence (including a home made provider-based to a hospital during the COVID-19 public health emergency) for subsequent repeat doses; service type: monoclonal antibody administration with monitoring; typical site of service: patient home or residence with post-administration monitoring.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A 68-year-old patient with multiple chronic conditions (for example, chronic obstructive pulmonary disease and type 2 diabetes) is diagnosed with early mild-to-moderate COVID-19 after a positive SARS-CoV-2 test and meets high-risk criteria for progression to severe disease. The patient is unable or prefers not to travel to an outpatient infusion center. A licensed clinician orders monoclonal antibody therapy consisting of casirivimab and imdevimab to be administered via intravenous infusion or subcutaneous injection at the patient’s home or residence. A qualified infusion nurse visits the home, performs pre-infusion assessment (vital signs, allergy review, informed consent confirmation), establishes IV access or prepares subcutaneous injections, administers the medication per protocol, and provides post-administration monitoring for infusion-related reactions for the required observation period. Documentation includes consent, medication lot numbers and doses, start and stop times, pre- and post-vital signs, any adverse events and interventions, and disposition. When the patient’s home has been made provider-based to the hospital during the public health emergency, billing follows the same code for home-based administration with monitoring. Subsequent repeat doses for the same therapeutic course are billed using the same HCPCS Level II code M0241 as specified for repeat administrations.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96365Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hourMay be used in facility reporting of the infusion component when local payer policy requires CPT reporting alongside HCPCS for infusion time tracking.
    96366Intravenous infusion; each additional hourUsed when infusion extends beyond the initial hour and time-based billing is required by the payer.
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularMay apply for reporting subcutaneous injection administration of medication when required.
    36415Collection of venous blood by venipuncturePerformed before or after infusion for baseline labs, serology, or safety monitoring when clinically indicated.
    99024Postoperative follow-up visit, routine; during global periodMay be used by some payers for follow-up evaluation related to the infusion if applicable under their policies.

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    225XM0800XMental Health Occupational TherapistOccupational therapists provide treatment for people recovering from a mental or physical illness to regain their independence and stability and to en…
    207RA0201XAllergy & Immunology (Internal Medicine) PhysicianAn internist doctor of osteopathy that specializes in the treatment of allergy and immunologic disorders. A doctor of osteopathy that is board eligib…
    172A00000XDriverA person employed to operate a motor vehicle as a carrier of persons or property.
    2472D0500XDarkroom TechnicianNone
    363LS0200XSchool Nurse PractitionerPhysician Assistants & Advanced Practice Nursing Providers · Nurse Practitioner
    207ND0101XMOHS-Micrographic Surgery PhysicianThe highly-trained surgeons that perform Mohs Micrographic Surgery are specialists both in dermatology and pathology. With their extensive knowledge o…

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    B97.29Other coronavirus as the cause of diseases classified elsewhere
    D50.9Iron deficiency anemia, unspecified
    E11.9Type 2 diabetes mellitus without complications
    F41.9Anxiety disorder, unspecified
    I10Essential (primary) hypertension
    J12.82Pneumonia due to coronavirus disease 2019
    J18.9Pneumonia, unspecified organism
    J22Unspecified acute lower respiratory infection
    J80Acute respiratory distress syndrome
    J96.00Acute respiratory failure, unspecified whether with hypoxia or hypercapnia

    Showing 1–10 of 27

    Related Codes

    HCPCS-M0075-CELLULAR-THERAPY-PROCESSING-PROVISION

    HCPCS Level II M0075: Cellular Therapy

    HCPCS-M0076-PROLOTHERAPY-INJECTION-THERAPY

    HCPCS Level II M0076: Prolotherapy

    HCPCS-M0100-INTRAGASTRIC-HYPOTHERMIA-GASTRIC-FREEZING

    HCPCS Level II M0100: Intragastric Hypothermia (Gastric Freezing)

    HCPCS-M0201-IN-HOME-VACCINE-ADMINISTRATION

    HCPCS Level II M0201: In-Home Vaccine Administration

    HCPCS-M0220-TIXAGEVIMAB-CILGAVIMAB-PRE-EXPOSURE-PROPHYLAXIS

    HCPCS Level II M0220: Tixagevimab and Cilgavimab Pre-Exposure Prophylaxis

    HCPCS-M0221-TIXAGEVIMAB-CILGAVIMAB-PRE-EXPOSURE-PROPHYLAXIS-HOME-ADMINISTRATION

    HCPCS M0221: Tixagevimab and Cilgavimab Pre-Exposure Prophylaxis

    HCPCS-M0222-BEBTELOVIMAB-INTRAVENOUS-INJECTION-MONITORING

    HCPCS Level II M0222: Bebtelovimab Intravenous Injection with Monitoring

    HCPCS-M0223-BEBTELOVIMAB-INTRAVENOUS-INJECTION-HOME-MONITORING

    HCPCS M0223: Intravenous Bebtelovimab with Home Monitoring

    HCPCS-M0224-PEMIVIBART-PRE-EXPOSURE-PROPHYLAXIS-INFUSION

    HCPCS M0224: Pemivibart Intravenous Infusion for Pre-Exposure Prophylaxis

    HCPCS-M0233-TOCILIZUMAB-INFUSION-COVID19-HOSPITALIZED-ADULTS

    HCPCS Level II M0233: Tocilizumab-aazg IV Infusion, First Dose

    Showing 1–10 of 27

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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