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    v1.0.30
    OpenPayerBilling CodesMiscellaneous Medical ServicesHCPCS hcpcs-m0075-cellular-therapy-processing-provision
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    HCPCS Level II M0075: Cellular Therapy

    HCPCS Level II code M0075 represents cellular therapy services, typically involving the preparation, handling, or administration of cellular products for therapeutic use; service type is cellular therapy procedures and the typical site of service is hospital outpatient departments, ambulatory surgical centers, or specialized infusion/ cell-therapy clinics.

    For related coverage guidance, see recent payer policy updates: Skilled Nursing and Skilled Rehabilitation Services (Outpatient), Habilitation and Rehabilitation Therapy (Occupational, Physical, and Speech) (for New Mexico Only), Physical Therapy/Medicine Corporate Medical Policy.

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    Clinical & Coding Specifications

    Clinical Context

    A 45-year-old patient with relapsed diffuse large B-cell lymphoma is evaluated for autologous cellular therapy using harvested and processed peripheral blood stem cells. The patient presents to an outpatient apheresis unit for cell collection, then to a specialized cell-processing laboratory for manipulation and cryopreservation, and later to an inpatient hematology/oncology unit for high-dose chemotherapy and reinfusion of the cellular product. The clinical workflow includes: pre-procedure eligibility assessment and informed consent; vascular access placement (central venous catheter or large-bore peripheral access) for apheresis; mobilization of stem cells with granulocyte-colony stimulating factor (G-CSF) with or without plerixafor; apheresis collection sessions to obtain the cellular product; cell processing, testing, and cryopreservation in a licensed cell-processing facility; storage and release testing; conditioning regimen administration; and reinfusion of the cellular therapy product with post-infusion monitoring for infusion reactions, engraftment, and infectious complications. Typical sites of service include outpatient apheresis centers, hospital-based cell-processing laboratories, and inpatient bone marrow transplant units. The patient scenario may require coordination with blood bank, pathology, and specialty pharmacy services for product tracking, chain-of-custody documentation, and payer authorization for cellular therapy services.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    38240Hematopoietic progenitor cell (HPC), autologous; allogeneic transplantation, bone marrow or peripheral blood, harvesting for transplantationUsed for the harvest/collection of stem cells for autologous or allogeneic transplantation; precedes processing and cryopreservation.
    36511Collection of blood for transfusion or cell separation (apheresis); for therapeutic apheresis procedures or collection of blood componentsUsed for apheresis collection sessions to obtain peripheral blood stem cells for cellular therapy.
    38205Bone marrow harvest for transplantation; from iliac crest, percutaneous, with or without general anesthesiaUsed if marrow harvest is performed instead of peripheral blood collection as the source of cellular product.
    38206Bone marrow harvest for transplantation; with open techniqueUsed for open surgical harvests when required for cellular therapy product procurement.
    38207Bone marrow harvest for transplantation; multiple separately identified harvests (List separately in addition to code for primary procedure)Used for additional harvest sessions when multiple collections are clinically necessary.
    38999Unlisted procedure, hemic, lymphatic, spleen (use when a specific CPT for a unique cell processing procedure is unavailable)Used for novel or highly specialized cell processing or manipulation procedures not described by existing CPT codes; requires documentation and potential prior authorization.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RH0000X
    364S00000X
    282N00000X
    363A00000X
    163WC2100X
    175T00000X
    207YX0602X
    2080S0010X

    Related Payer Policy Updates

    Specialty: Physical Medicine, Rehab & Therapies1 / 3

    10 rows

    PolicyPayerEffective Date
    Skilled Nursing and Skilled Rehabilitation Services (Outpatient)Anthem2026-10-01
    Habilitation and Rehabilitation Therapy (Occupational, Physical, and Speech) (for New Mexico Only)UnitedHealthcare2026-10-01
    Physical Therapy/Medicine Corporate Medical Policybcbsvermont2026-10-01
    Speech Language Pathology/Therapy Services Corporate Medical Policybcbsvermont2026-10-01
    Cognitive Rehabilitation Corporate Medical Policybcbsvermont2026-10-01
    Occupational Therapy Corporate Medical Policybcbsvermont2026-10-01
    Biomagnetic TherapyConnectiCare2026-09-11
    Habilitation and Rehabilitation Therapy (Occupational, Physical, and Speech) (for Idaho Only)UnitedHealthcare2026-09-01
    Rehabilitation Services (Physical, Occupational, and Speech Therapy)UnitedHealthcare2026-09-01
    Manipulative Therapy (for Tennessee Only)UnitedHealthcare2026-09-01

    Related Codes

    HCPCS-M0076-PROLOTHERAPY-INJECTION-THERAPY

    HCPCS Level II M0076: Prolotherapy

    HCPCS-M0100-INTRAGASTRIC-HYPOTHERMIA-GASTRIC-FREEZING

    HCPCS Level II M0100: Intragastric Hypothermia (Gastric Freezing)

    HCPCS-M0201-IN-HOME-VACCINE-ADMINISTRATION

    HCPCS Level II M0201: In-Home Vaccine Administration

    HCPCS-M0220-TIXAGEVIMAB-CILGAVIMAB-PRE-EXPOSURE-PROPHYLAXIS

    HCPCS Level II M0220: Tixagevimab and Cilgavimab Pre-Exposure Prophylaxis

    HCPCS-M0221-TIXAGEVIMAB-CILGAVIMAB-PRE-EXPOSURE-PROPHYLAXIS-HOME-ADMINISTRATION

    HCPCS M0221: Tixagevimab and Cilgavimab Pre-Exposure Prophylaxis

    HCPCS-M0222-BEBTELOVIMAB-INTRAVENOUS-INJECTION-MONITORING

    HCPCS Level II M0222: Bebtelovimab Intravenous Injection with Monitoring

    HCPCS-M0223-BEBTELOVIMAB-INTRAVENOUS-INJECTION-HOME-MONITORING

    HCPCS M0223: Intravenous Bebtelovimab with Home Monitoring

    HCPCS-M0224-PEMIVIBART-PRE-EXPOSURE-PROPHYLAXIS-INFUSION

    HCPCS M0224: Pemivibart Intravenous Infusion for Pre-Exposure Prophylaxis

    HCPCS-M0233-TOCILIZUMAB-INFUSION-COVID19-HOSPITALIZED-ADULTS

    HCPCS Level II M0233: Tocilizumab-aazg IV Infusion, First Dose

    HCPCS-M0234-TOCILIZUMAB-INFUSION-HOSPITALIZED-COVID19

    HCPCS Level II M0234: Tocilizumab Infusion for Hospitalized Adults with COVID-19

    Showing 1–10 of 27

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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