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    v1.0.31
    OpenPayerBilling CodesMiscellaneous Medical ServicesHCPCS hcpcs-m0223-bebtelovimab-intravenous-injection-home-monitoring
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    HCPCS M0223: Intravenous Bebtelovimab with Home Monitoring

    HCPCS Level II code M0223 describes an intravenous injection of bebtelovimab with included injection and post-administration monitoring provided in the patient’s home or residence (including a beneficiary’s home designated provider-based during the COVID-19 public health emergency); service type: infusion/IV therapeutic administration with monitoring; typical site of service: patient home or residence with home-based post-administration observation.

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    Table of contents

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    Clinical & Coding Specifications

    Clinical Context

    A home infusion nurse visits an adult beneficiary recently diagnosed with mild-to-moderate COVID-19 who is at high risk for progression to severe disease (for example, advanced age, immunocompromise, or multiple chronic comorbidities). The clinician orders a single-dose intravenous monoclonal antibody, bebtelovimab, to be administered in the patient’s home. Prior to infusion the nurse verifies identity, documents informed consent and allergies, assesses vital signs, and establishes IV access. The nurse prepares and administers M0223 per product monograph, observes the patient during and for a monitored post-administration period for infusion reactions, documents the infusion start and stop times, and provides discharge instructions. If the beneficiary’s residence is temporarily made provider-based to the hospital during the COVID-19 Public Health Emergency, the same home-based workflow and monitoring requirements apply under M0223. Typical workflow steps: pre-visit remote screening, in-home nursing visit for medication verification and IV administration, continuous clinical observation during infusion, post-infusion monitoring for adverse events, and documentation of administration, monitoring, and any interventions performed.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96365Intravenous infusion, therapeutic, prophylactic, or diagnostic; initial, up to 1 hourMay be used when documenting concurrent IV infusion services if payer requires CPT-level reporting alongside HCPCS billing.
    96366Intravenous infusion, each additional hourUse if extended infusion or prolonged monitoring beyond the initial hour is medically necessary and reported.
    96372Therapeutic, prophylactic, or diagnostic injection (SC, IM)Not used for IV bebtelovimab but may appear in the record for other contemporaneous injections.
    36415Collection of venous blood by venipunctureOften performed prior to or during the visit for baseline labs or safety monitoring.
    99024Postoperative follow-up visit, routine; global period not specified (sometimes used for post-procedure monitoring)May be used in some settings to document post-infusion follow-up communications or visits when billable.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207RC0000X
    207L00000X
    364SN0000X
    261QM0850X
    213ES0103X
    363L00000X
    207ZN0500X
    207WX0009X

    Related ICD-10-CM Codes

    27 rows

    ICD-10-CM CodeDescription
    B34.2Coronavirus infection, unspecified
    B97.29Other coronavirus as the cause of diseases classified elsewhere
    D50.9Iron deficiency anemia, unspecified
    D68.9Coagulation defect, unspecified
    E66.9Obesity, unspecified
    J12.89Other viral pneumonia
    J12.9Viral pneumonia, unspecified
    J18.9Pneumonia, unspecified organism
    J20.9Acute bronchitis, unspecified
    J21.9Acute bronchiolitis, unspecified

    Showing 1–10 of 27

    Related Codes

    HCPCS-M0075-CELLULAR-THERAPY-PROCESSING-PROVISION

    HCPCS Level II M0075: Cellular Therapy

    HCPCS-M0076-PROLOTHERAPY-INJECTION-THERAPY

    HCPCS Level II M0076: Prolotherapy

    HCPCS-M0100-INTRAGASTRIC-HYPOTHERMIA-GASTRIC-FREEZING

    HCPCS Level II M0100: Intragastric Hypothermia (Gastric Freezing)

    HCPCS-M0201-IN-HOME-VACCINE-ADMINISTRATION

    HCPCS Level II M0201: In-Home Vaccine Administration

    HCPCS-M0220-TIXAGEVIMAB-CILGAVIMAB-PRE-EXPOSURE-PROPHYLAXIS

    HCPCS Level II M0220: Tixagevimab and Cilgavimab Pre-Exposure Prophylaxis

    HCPCS-M0221-TIXAGEVIMAB-CILGAVIMAB-PRE-EXPOSURE-PROPHYLAXIS-HOME-ADMINISTRATION

    HCPCS M0221: Tixagevimab and Cilgavimab Pre-Exposure Prophylaxis

    HCPCS-M0222-BEBTELOVIMAB-INTRAVENOUS-INJECTION-MONITORING

    HCPCS Level II M0222: Bebtelovimab Intravenous Injection with Monitoring

    HCPCS-M0224-PEMIVIBART-PRE-EXPOSURE-PROPHYLAXIS-INFUSION

    HCPCS M0224: Pemivibart Intravenous Infusion for Pre-Exposure Prophylaxis

    HCPCS-M0233-TOCILIZUMAB-INFUSION-COVID19-HOSPITALIZED-ADULTS

    HCPCS Level II M0233: Tocilizumab-aazg IV Infusion, First Dose

    HCPCS-M0234-TOCILIZUMAB-INFUSION-HOSPITALIZED-COVID19

    HCPCS Level II M0234: Tocilizumab Infusion for Hospitalized Adults with COVID-19

    Showing 1–10 of 27

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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