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    v1.0.30
    OpenPayerBilling CodesMiscellaneous Medical ServicesHCPCS hcpcs-m0100-intragastric-hypothermia-gastric-freezing
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    HCPCS Level II M0100: Intragastric Hypothermia (Gastric Freezing)

    HCPCS Level II code M0100 describes intragastric hypothermia using gastric freezing, a therapeutic procedure that applies controlled cooling within the stomach to achieve local hypothermia; the service is a specialized endoscopic or interventional gastroenterology procedure typically performed in an inpatient or outpatient hospital setting or an endoscopy suite.

    For related coverage guidance, see recent payer policy updates: Skilled Nursing and Skilled Rehabilitation Services (Outpatient), Habilitation and Rehabilitation Therapy (Occupational, Physical, and Speech) (for New Mexico Only), Physical Therapy/Medicine Corporate Medical Policy.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient for M0100 (intragastric hypothermia using gastric freezing) is an adult with severe hypermetabolic state, refractory intracranial hypertension with elevated core temperature, or select post-cardiac arrest patients for targeted temperature modulation when intragastric cooling is chosen. The patient is evaluated by the critical care team and/or interventional gastroenterology or critical care proceduralist. Pre-procedure assessment includes review of indications, contraindications, coagulation status, and recent imaging or endoscopy as appropriate. The procedure is performed in an inpatient setting — commonly an intensive care unit or a monitored procedural suite — under moderate sedation or general anesthesia depending on patient stability. A nasogastric or orogastric approach is used to position the gastric cooling device under direct visualization or with imaging guidance; device activation achieves controlled intragastric hypothermia. Continuous monitoring of core temperature, hemodynamics, and potential complications (bleeding, aspiration, gastric mucosal injury) occurs during therapy. Documentation includes indication, informed consent, device type, insertion method, sedation/anesthesia, temperature targets and duration, any adjunctive measures, and post-procedure plan for device removal and rewarming protocols.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    43238Esophagogastroduodenoscopy, flexible, transoral; with biopsy, single or multipleMay be used before or during device placement for evaluation or guiding intragastric device insertion
    43239Esophagogastroduodenoscopy, flexible, transoral; with directed submucosal injection(s), any substanceMay be used adjunctively if endoscopic maneuvers are required during device placement or control of gastric mucosa
    99152Moderate sedation services provided by the physician or other qualified health care professional, initial 15 minutesUsed when moderate sedation is provided by the billing clinician for device placement in a non-anesthetized patient
    01402Anesthesia for procedures on esophagus and stomach; not otherwise specifiedUse when general anesthesia is provided for intragastric device placement and reported by anesthesia providers
    99155Moderate sedation services by the same physician performing the procedure, additional 15 minutesUse for prolonged sedation time when the proceduralist also provides moderate sedation and timing exceeds base increments

    Related Modifiers

    10 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    26Modifier 26 (Professional Component) identifies and bills only the professional portion of a split service — the physician’s interpretation, report, and medical judgment — when the technical…- Use CPT Modifier -26 when you are billing only the professional component (PC) of a split‑bill eligible service—i.e., you performed the physician interpretation, medical judgment and prepared a…
    32Modifier 32 (Mandated Services) indicates that a CPT-coded service was required by a third party—such as an insurer, school, state agency, or court. The AMA defines it as denoting services mandated…- Use Modifier 32 when a service or procedure was explicitly mandated by a third party (for example an insurer requiring a second opinion, a school requiring a sports physical, a state agency or…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…

    Related Provider Taxonomies

    8 rows

    Taxonomy Code
    207P00000X
    208000000X
    207L00000X
    363L00000X
    363A00000X
    163WN1003X
    156FX1202X
    253Z00000X

    Related Payer Policy Updates

    Specialty: Physical Medicine, Rehab & Therapies1 / 3

    10 rows

    PolicyPayerEffective Date
    Skilled Nursing and Skilled Rehabilitation Services (Outpatient)Anthem2026-10-01
    Habilitation and Rehabilitation Therapy (Occupational, Physical, and Speech) (for New Mexico Only)UnitedHealthcare2026-10-01
    Physical Therapy/Medicine Corporate Medical Policybcbsvermont2026-10-01
    Speech Language Pathology/Therapy Services Corporate Medical Policybcbsvermont2026-10-01
    Cognitive Rehabilitation Corporate Medical Policybcbsvermont2026-10-01
    Occupational Therapy Corporate Medical Policybcbsvermont2026-10-01
    Biomagnetic TherapyConnectiCare2026-09-11
    Habilitation and Rehabilitation Therapy (Occupational, Physical, and Speech) (for Idaho Only)UnitedHealthcare2026-09-01
    Rehabilitation Services (Physical, Occupational, and Speech Therapy)UnitedHealthcare2026-09-01
    Manipulative Therapy (for Tennessee Only)UnitedHealthcare2026-09-01

    Related Codes

    HCPCS-M0075-CELLULAR-THERAPY-PROCESSING-PROVISION

    HCPCS Level II M0075: Cellular Therapy

    HCPCS-M0076-PROLOTHERAPY-INJECTION-THERAPY

    HCPCS Level II M0076: Prolotherapy

    HCPCS-M0201-IN-HOME-VACCINE-ADMINISTRATION

    HCPCS Level II M0201: In-Home Vaccine Administration

    HCPCS-M0220-TIXAGEVIMAB-CILGAVIMAB-PRE-EXPOSURE-PROPHYLAXIS

    HCPCS Level II M0220: Tixagevimab and Cilgavimab Pre-Exposure Prophylaxis

    HCPCS-M0221-TIXAGEVIMAB-CILGAVIMAB-PRE-EXPOSURE-PROPHYLAXIS-HOME-ADMINISTRATION

    HCPCS M0221: Tixagevimab and Cilgavimab Pre-Exposure Prophylaxis

    HCPCS-M0222-BEBTELOVIMAB-INTRAVENOUS-INJECTION-MONITORING

    HCPCS Level II M0222: Bebtelovimab Intravenous Injection with Monitoring

    HCPCS-M0223-BEBTELOVIMAB-INTRAVENOUS-INJECTION-HOME-MONITORING

    HCPCS M0223: Intravenous Bebtelovimab with Home Monitoring

    HCPCS-M0224-PEMIVIBART-PRE-EXPOSURE-PROPHYLAXIS-INFUSION

    HCPCS M0224: Pemivibart Intravenous Infusion for Pre-Exposure Prophylaxis

    HCPCS-M0233-TOCILIZUMAB-INFUSION-COVID19-HOSPITALIZED-ADULTS

    HCPCS Level II M0233: Tocilizumab-aazg IV Infusion, First Dose

    HCPCS-M0234-TOCILIZUMAB-INFUSION-HOSPITALIZED-COVID19

    HCPCS Level II M0234: Tocilizumab Infusion for Hospitalized Adults with COVID-19

    Showing 1–10 of 27

    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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