HCPCS Level II J2267: Mirikizumab-mrkz Injection, 1 mg

HCPCS Level II code J2267 describes an injectable biologic product, mirikizumab-mrkz, dosed as 1 mg per unit, used for subcutaneous or intramuscular administration in outpatient infusion clinics, physician offices, or ambulatory care settings where biologic injections are given. This HCPCS Level II code is assigned to the drug itself for billing drug administration and product reporting separate from the procedure for giving the injection, and is used in claims to indicate dispensing of mirikizumab-mrkz at the specified unit strength for clinical services involving biologic therapy.

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HCPCS Level II J2267: Mirikizumab-mrkz Injection, 1 mg

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Get alerted when payer policies referencing J2267 are released or updated.

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Clinical & Coding Specifications

Clinical Context

A typical patient is a 28–55-year-old adult with moderate to severe plaque psoriasis or active ulcerative colitis who has been prescribed subcutaneous biologic therapy with mirikizumab-mrkz. The patient presents to an outpatient infusion/ injection clinic, ambulatory surgery center, or physician office for administration of the prescribed dose. The clinician—commonly a dermatologist, gastroenterologist, or registered nurse—verifies the medication order, performs a pre-injection assessment (including allergies, recent infections, and pregnancy status), documents baseline vital signs, and prepares the prefilled syringe or vial containing mirikizumab-mrkz. The medication is administered subcutaneously; the injection site is observed for immediate adverse reaction for 15–30 minutes per clinic protocol. Post-administration documentation includes lot number, NDC when available, date/time, route, dose in mg, administering provider taxonomy, and any patient education provided regarding delayed adverse effects and follow-up dosing schedule. Billing uses the HCPCS Level II code J2267 reported per milligram of mirikizumab-mrkz administered, with appropriate modifier(s) to reflect circumstances such as split/shared services, billing for discarded drug, or unrelated services during the same encounter.

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	Commonly billed for the professional administration of a subcutaneous biologic like `mirikizumab-mrkz` when payer allows separate administration coding.
`96401`	Chemotherapy administration, subcutaneous or intramuscular; non-hormonal antineoplastic	May be used in specialized billing contexts when payers require a chemotherapy administration code for biologic agents with similar administration requirements; verify payer policy.
`99070`	Supplies and materials (e.g., drugs, trays) provided by the physician over and above those usually included with the office visit or procedure	Used to bill for additional supplies related to injection if payer permits.
`99406`	Data not available in the input.	Data not available in the input.
`99213`	Office or other outpatient visit for the evaluation and management of an established patient, typically 15 minutes	Often billed on the same day for evaluation related to initiation or monitoring of biologic therapy, when medically necessary and documented.
`99001`	Data not available in the input.	Data not available in the input.

Related Modifiers

5 rows

Modifier	Description	When to Use
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
23	Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…	- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RH0000X	Hematology (Internal Medicine) Physician	An internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
207LP2900X	Pain Medicine (Anesthesiology) Physician	An anesthesiologist who provides a high level of care, either as a primary physician or consultant, for patients experiencing problems with acute, chr…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
374U00000X	Home Health Aide	A person trained to assist public health nurses, home health nurses, and other health professionals in the bedside care of patients in their homes.
172V00000X	Community Health Worker	Community health workers (CHW) are lay members of communities who work either for pay or as volunteers in association with the local health care syste…
261QM2500X	Medical Specialty Clinic/Center	An entity, facility, or distinct part of a facility providing diagnostic, treatment, and prescriptive services related to a specific area of medical s…
163WC0400X	Case Management Registered Nurse	Nursing Service Providers · Registered Nurse
171M00000X	Case Manager/Care Coordinator	A person who provides case management services and assists an individual in gaining access to needed medical, social, educational, and/or other servic…

Related ICD-10-CM Codes

24 rows

ICD-10-CM Code	Description
B18.2	Chronic viral hepatitis C
D89.89	Other specified disorders involving the immune mechanism, not elsewhere classified
E66.9	Obesity, unspecified
K50.10	Crohn's disease of large intestine without complications
K50.111	Crohn's disease of large intestine with rectal bleeding
K50.112	Crohn's disease of large intestine with intestinal obstruction
K50.90	Crohn's disease, unspecified, without complications
K50.919	Crohn's disease, unspecified, with unspecified complications
K51.90	Ulcerative colitis, unspecified, without complications
L21.9	Seborrheic dermatitis, unspecified

Showing 1–10 of 24

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

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Clinical & Coding Specifications

Clinical Context

Related CPT Codes

CPT Code	Description	Relationship to This Procedure
`96372`	Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular	Commonly billed for the professional administration of a subcutaneous biologic like `mirikizumab-mrkz` when payer allows separate administration coding.
`96401`	Chemotherapy administration, subcutaneous or intramuscular; non-hormonal antineoplastic	May be used in specialized billing contexts when payers require a chemotherapy administration code for biologic agents with similar administration requirements; verify payer policy.
`99070`	Supplies and materials (e.g., drugs, trays) provided by the physician over and above those usually included with the office visit or procedure	Used to bill for additional supplies related to injection if payer permits.
`99406`	Data not available in the input.	Data not available in the input.
`99213`	Office or other outpatient visit for the evaluation and management of an established patient, typically 15 minutes	Often billed on the same day for evaluation related to initiation or monitoring of biologic therapy, when medically necessary and documented.
`99001`	Data not available in the input.	Data not available in the input.

Related Modifiers

5 rows

Modifier	Description	When to Use
62	Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…	- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
78	CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…	- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
80	CPT® Modifier 80 (Assistant Surgeon) is appended to a surgical CPT code when a physician (MD or DO) provides full, continuous assistance throughout the operative procedure. It is intended only for…	- Use CPT Modifier -80 when a physician (MD or DO) serves as an assistant surgeon and provides full, continuous assistance throughout the entire operative procedure; append -80 to the surgical CPT…
23	Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…	- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
52	Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…	- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…

Related Provider Taxonomies

8 rows

Taxonomy Code	Specialty	Notes
207RH0000X	Hematology (Internal Medicine) Physician	An internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, cl…
207LP2900X	Pain Medicine (Anesthesiology) Physician	An anesthesiologist who provides a high level of care, either as a primary physician or consultant, for patients experiencing problems with acute, chr…
207L00000X	Anesthesiology Physician	An anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
374U00000X	Home Health Aide	A person trained to assist public health nurses, home health nurses, and other health professionals in the bedside care of patients in their homes.
172V00000X	Community Health Worker	Community health workers (CHW) are lay members of communities who work either for pay or as volunteers in association with the local health care syste…
261QM2500X	Medical Specialty Clinic/Center	An entity, facility, or distinct part of a facility providing diagnostic, treatment, and prescriptive services related to a specific area of medical s…
163WC0400X	Case Management Registered Nurse	Nursing Service Providers · Registered Nurse
171M00000X	Case Manager/Care Coordinator	A person who provides case management services and assists an individual in gaining access to needed medical, social, educational, and/or other servic…

Related ICD-10-CM Codes

24 rows

ICD-10-CM Code	Description
B18.2	Chronic viral hepatitis C
D89.89	Other specified disorders involving the immune mechanism, not elsewhere classified
E66.9	Obesity, unspecified
K50.10	Crohn's disease of large intestine without complications
K50.111	Crohn's disease of large intestine with rectal bleeding
K50.112	Crohn's disease of large intestine with intestinal obstruction
K50.90	Crohn's disease, unspecified, without complications
K50.919	Crohn's disease, unspecified, with unspecified complications
K51.90	Ulcerative colitis, unspecified, without complications
L21.9	Seborrheic dermatitis, unspecified

Showing 1–10 of 24

Related Codes

HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

HCPCS Level II J0121: Omadacycline Injection, 1 mg

HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

HCPCS Level II J0122: Injection, eravacycline, 1 mg

HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

HCPCS Level II J0129: Abatacept Injection, 10 mg

HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

HCPCS Level II J0130: Injection abciximab, 10 mg

HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

HCPCS Level II J0131: Injection, Acetaminophen 10 mg

HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

HCPCS Level II J0133: Injection, Acyclovir 5 mg

HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

Showing 1–10 of 991

Frequently Asked Questions

References

1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.

Published by

Trek Health powers OpenPayer with a leading commercial payer intelligence platform, seamlessly converting fragmented payer data into actionable insights for provider organizations.

HCPCS Level II J2267: Mirikizumab-mrkz Injection, 1 mg

Sign up for hcpcs J2267 policy alerts

HCPCS Level II J2267: Mirikizumab-mrkz Injection, 1 mg

Sign up for hcpcs J2267 policy alerts

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS code J2267 represent and how is it billed?

Where is mirikizumab-mrkz (J2267) typically administered and what documentation is required?

Which modifiers should be considered when billing J2267?

Are there related CPT or other codes commonly billed with J2267?

What diagnoses and payers are commonly associated with billing J2267?

References

Clinical & Coding Specifications

Clinical Context

Related CPT Codes

Related Modifiers

Related Provider Taxonomies

Related ICD-10-CM Codes

Related Codes

What does HCPCS code J2267 represent and how is it billed?

Where is mirikizumab-mrkz (J2267) typically administered and what documentation is required?

Which modifiers should be considered when billing J2267?

Are there related CPT or other codes commonly billed with J2267?

What diagnoses and payers are commonly associated with billing J2267?

References