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    v1.0.28
    OpenPayerBilling CodesDrugs Administered Other than Oral MethodHCPCS hcpcs-j2780-ranitidine-injection-25mg
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    HCPCS Level II J2780: Injection, ranitidine hydrochloride 25 mg

    HCPCS Level II code J2780 describes an injection of ranitidine hydrochloride 25 mg, a single-dose parenteral antacid/H2-receptor antagonist medication typically administered as an intravenous or intramuscular injection for acute management of gastric acidity or related conditions; the service type is pharmacologic injection, and the typical site of service is hospital inpatient, emergency department, or outpatient infusion/clinic setting.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult presenting to an urgent care clinic or hospital emergency department with acute gastrointestinal bleeding, severe gastritis, peptic ulcer disease with active bleeding, or as premedication before endoscopic procedures. The clinician documents intravenous administration of J2780 (injection, ranitidine hydrochloride, 25 mg) when a rapid H2-receptor antagonist effect is required to reduce gastric acid secretion and stabilize the patient prior to diagnostic or therapeutic intervention. The workflow includes assessment of allergy status and current medications, establishing IV access, ordering J2780 on the medication administration record, administering the dose per facility protocol, monitoring vital signs and response, and documenting the medication name, dose, route, time, lot number, and administering clinician. Ranitidine injection is often used when oral administration is not possible or when a parenteral H2 blocker is preferred for acute management. The medication may be given alone or as part of resuscitation and stabilization prior to endoscopy or surgery.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96365Intravenous infusion, for therapy, prophylaxis, or diagnosis; initial, up to 1 hourMay be reported when IV ranitidine is administered as an infusion and infusion services meet the CPT definition and documentation requirements.
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularNot typically used for IV ranitidine; included when alternative routes are used or for similar single-drug injection services in the same encounter.
    43235Upper gastrointestinal endoscopy including esophagus, stomach, and either the duodenum and/or jejunum, diagnostic, with biopsyOften performed after stabilization with J2780 for active upper GI bleeding or erosive disease; ranitidine may be given pre- or post-procedure.
    43255Upper gastrointestinal endoscopy with control of bleeding, any methodRanitidine administration may occur in the same encounter for acid suppression when endoscopic hemostasis is performed.
    99070Supplies and materials (except spectacles), provided by the physician over and above those usually included with the office visit or other services)Used to bill for additional supplies associated with IV medication administration when allowed by payer policy.

    Related Modifiers

    8 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    363A00000XPhysician AssistantA physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
    208M00000XHospitalist PhysicianHospitalists are physicians whose primary professional focus is the general medical care of hospitalized patients. Their activities include patient ca…
    224900000XMastectomy FitterAn individual trained in the fitting and adjusting of breast prostheses and management of post-mastectomy prostheses services.
    320800000XMental Illness Community Based Residential Treatment FacilityA home-like residential facility providing psychiatric treatment and psycho/social rehabilitative services to individuals diagnosed with mental illnes…
    207ZI0100XImmunopathology PhysicianA pathologist who specializes in the diagnosis of immunologic diseases.
    2471V0105XVascular Sonography Radiologic TechnologistA radiologic technologist who specializes in vascular sonography and is trained in the use of ultrasound equipment to image veins and arteries, which …

    Related Codes

    HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

    HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

    HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

    HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

    HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

    HCPCS Level II J0121: Omadacycline Injection, 1 mg

    HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

    HCPCS Level II J0122: Injection, eravacycline, 1 mg

    HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

    HCPCS Level II J0129: Abatacept Injection, 10 mg

    HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

    HCPCS Level II J0130: Injection abciximab, 10 mg

    HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

    HCPCS Level II J0131: Injection, Acetaminophen 10 mg

    HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

    HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

    HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

    HCPCS Level II J0133: Injection, Acyclovir 5 mg

    HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

    HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

    Showing 1–10 of 991

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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