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    v1.0.28
    OpenPayerBilling CodesDrugs Administered Other than Oral MethodHCPCS hcpcs-j1230-methadone-injection-10mg
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    HCPCS J1230: Injection, Methadone HCl up to 10 mg

    HCPCS Level II code J1230 describes an injectable medication service for methadone hydrochloride, up to 10 mg, typically billed when a clinician administers a controlled opioid agent; the service type is injectable medication administration and the typical site of service is outpatient clinic or hospital outpatient department where parenteral controlled-substance injections are provided.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only), Antibody-Drug Conjugates.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult enrolled in an outpatient medication-assisted treatment (MAT) program for opioid use disorder who presents to a clinic for directly observed therapy. The patient has a history of opioid dependence and is receiving methadone as part of a structured maintenance plan. At arrival, nursing staff verify identity, perform brief vitals and withdrawal assessment, review the current treatment plan and medication dose, and confirm consent for supervised administration. The clinic prepares a single-dose injectable methadone formulation labeled as J1230 (injection, methadone HCl, up to 10 mg). A licensed clinician or authorized dispenser administers the intramuscular or subcutaneous injection per facility protocol, documents lot number and dose on the medication administration record, observes the patient for adverse reaction for the required monitoring period, and records the encounter in the electronic health record. Billing is submitted using J1230 with applicable modifiers to indicate circumstances such as professional component, unusual services, or patient status changes. Typical sites of service include outpatient opioid treatment programs, ambulatory clinics, community health centers, and hospital outpatient departments. Typical documentation includes indication (opioid dependence), signed consent for methadone therapy, dosage administered, route, site, lot number, supervising provider, and post-administration observations.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    96372Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscularCommonly billed for administration of injectable medications when payer requires a CPT for the administration in addition to the drug HCPCS code J1230.

    | 99070 | Supplies and materials (except spectacles), provided by the physician over and above those usually included with the office visit or procedure (list drugs, trays, supplies) | Used to report additional disposable supplies associated with injection preparation and administration when payers allow.

    | 99406 | Smoking and tobacco use cessation counseling visits, intermediate, greater than 3 minutes up to 10 minutes | Often part of behavioral interventions delivered in the same visit for patients in substance use treatment programs (billed separately when applicable).

    | 99407 | Smoking and tobacco use cessation counseling, intensive, greater than 10 minutes | Used when longer counseling sessions occur alongside methadone administration as part of comprehensive care.

    | G2086 | Submission of patient-specific opioid treatment plan (example G-code used in some programs) | Used in certain opioid treatment program workflows to reflect care management and treatment planning alongside medication administration.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…
    78CPT modifier -78 indicates an unplanned, related return to the operating or procedure room by the same provider during the global postoperative period. It is appended when treatment for a…- Use modifier -78 when an unplanned, related complication during the original procedure’s global postoperative period requires the patient to return to a formal operating or procedure room and the…
    91Modifier 91 — “Repeat Clinical Diagnostic Laboratory Test” — is appended when the exact same CPT laboratory test is performed more than once for the same patient on the same day because serial,…- Use modifier 91 when the exact same CPT laboratory test is performed more than once on the same patient on the same date because serial or repeated testing is medically necessary to monitor…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    208000000XPediatrics PhysicianA pediatrician is concerned with the physical, emotional and social health of children from birth to young adulthood. Care encompasses a broad spectru…
    208D00000XGeneral Practice PhysicianA physician who specializes in the general practice of diagnosing, treating, and managing patients with a variety of illnesses and conditions.
    207Q00000XFamily Medicine PhysicianFamily Medicine is the medical specialty which is concerned with the total health care of the individual and the family. It is the specialty in breadt…
    363A00000XPhysician AssistantA physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
    363L00000XNurse Practitioner(1) A registered nurse provider with a graduate degree in nursing prepared for advanced practice involving independent and interdependent decision mak…
    174MM1900XMedical Research VeterinarianOther Service Providers · Veterinarian
    332G00000XEye BankAn eye bank procures and distributes eyes for transplant, education and research. To promote patient safety, donated eyes and donor medial histories a…
    231HA2400XAssistive Technology Practitioner AudiologistSpeech, Language and Hearing Service Providers · Audiologist

    Related ICD-10-CM Codes

    26 rows

    ICD-10-CM CodeDescription
    F10.20Alcohol dependence, uncomplicated
    F11.10Opioid abuse, uncomplicated
    F11.14Opioid abuse with opioid-induced mood disorder
    F11.150Opioid abuse with opioid-induced psychotic disorder with delusions
    F11.20Opioid dependence, uncomplicated
    F11.21Opioid dependence, in remission
    F11.23Opioid dependence with withdrawal
    F11.24Opioid dependence with opioid-induced mood disorder
    F11.29Opioid dependence with unspecified opioid-induced disorder
    F11.90Opioid use, unspecified, uncomplicated

    Showing 1–10 of 26

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    4 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01
    Chemotherapy Observation or Inpatient Hospitalization (for New Mexico Only)UnitedHealthcare2026-08-01
    Antibody-Drug ConjugatesPremera Bluecross2026-08-01
    Umbilical Cord Blood Harvesting and Storage for Future Use (for Indiana Only)UnitedHealthcare2026-08-01

    Related Codes

    HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

    HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

    HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

    HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

    HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

    HCPCS Level II J0121: Omadacycline Injection, 1 mg

    HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

    HCPCS Level II J0122: Injection, eravacycline, 1 mg

    HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

    HCPCS Level II J0129: Abatacept Injection, 10 mg

    HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

    HCPCS Level II J0130: Injection abciximab, 10 mg

    HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

    HCPCS Level II J0131: Injection, Acetaminophen 10 mg

    HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

    HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

    HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

    HCPCS Level II J0133: Injection, Acyclovir 5 mg

    HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

    HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

    Showing 1–10 of 991

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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