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    v1.0.28
    OpenPayerBilling CodesDrugs Administered Other than Oral MethodHCPCS hcpcs-j0583-bivalirudin-injection-1mg
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    HCPCS Level II J0583: Injection, bivalirudin, 1 mg

    HCPCS Level II code J0583 describes an injectable anticoagulant product, bivalirudin dosed per 1 mg for use as an intravenous medication; the service type is medication administration and the typical site of service is an inpatient hospital or outpatient infusion/ambulatory setting where anticoagulant infusions or procedural anticoagulation are provided.

    For related coverage guidance, see recent payer policy updates: Epithelial Cell Cytology in Breast Cancer Risk Assessment, B-Hemolytic Streptococcus Testing, Human Immunodeficiency Virus (HIV) — Coverage Criteria for Testing and Resistance Assays.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is a 65-year-old male admitted to the cardiac catheterization laboratory for percutaneous coronary intervention (PCI) following an acute coronary syndrome. The interventional cardiology team orders anticoagulation with bivalirudin administered intravenously as a weight-based infusion and bolus for procedural anticoagulation and thrombosis prevention. Pharmacy prepares unit doses of bivalirudin; billing is submitted per milligram using J0583 for the actual quantity administered. The usual workflow: pre-procedure consent and verification, weight-based dose calculation, medication preparation by pharmacy or nursing, administration in the cath lab by registered nurses under the direction of the cardiologist, monitoring of activated clotting times or per institutional protocol, documentation of dose, time, and any waste (reported with modifier JW when applicable), and post-procedure monitoring in the recovery area or coronary care unit.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    92928Percutaneous transluminal coronary angioplasty, single major coronary artery; with stent placementFrequently performed procedure during which J0583 bivalirudin is administered for intraprocedural anticoagulation.
    93458Catheter placement in coronary artery for coronary angiography including intraprocedural imaging and hemodynamic measurements with percutaneous coronary intervention when performedDiagnostic and interventional catheter procedures during which bivalirudin is commonly used.
    93000Electrocardiogram, routine ECG with at least 12 leads; with interpretation and reportPre- and post-procedure ECG monitoring commonly performed in the same encounter where bivalirudin is administered.
    36415Collection of venous blood by venipunctureLabs such as activated clotting times or chemistries drawn before/after administration of an anticoagulant.
    99152Moderate sedation services provided by the same physician performing the procedure (report per sedation rules)Sedation services that may occur alongside PCI where bivalirudin is used (report only if applicable and per payer guidelines).

    Related Modifiers

    6 rows

    ModifierDescriptionWhen to Use
    59Modifier 59 indicates a distinct procedural service when two procedures that are not normally billed together are clinically and procedurally separate. The CPT definition (as reiterated by CMS)…- Use modifier -59 to report a distinct procedural service when documentation supports that the procedure reported is not normally billed together with another service on the same day because of a…
    76Modifier -76, Repeat Procedure or Service by Same Physician or Other Qualified Health Care Professional, is appended when the same provider performs an identical, medically necessary procedure or…- Use modifier -76 when the same physician or other qualified health care professional performs an identical procedure or service a second (or subsequent) time on the same date of service and the…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    2084P0800XPsychiatry PhysicianA Psychiatrist specializes in the prevention, diagnosis, and treatment of mental disorders, emotional disorders, psychotic disorders, mood disorders, …
    207RC0000XCardiovascular Disease PhysicianAn internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions such as heart attacks and life-threaten…
    363A00000XPhysician AssistantA physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
    163W00000XRegistered Nurse(1) A registered nurse is a person qualified by graduation from an accredited nursing school (depending upon schooling, a registered nurse may receive…
    281PC2000XChildren's Chronic Disease HospitalHospitals · Chronic Disease Hospital
    2251C2600XCardiopulmonary Physical TherapistA licensed physical therapist, including but not limited to an individual who is a Board Certified Specialist in Cardiovascular & Pulmonary Physical T…
    1744R1102XResearch Study SpecialistOther Service Providers · Specialist
    207SM0001XMolecular Genetic Pathology (Medical Genetics) PhysicianA board certified subspecialty, the molecular genetic pathologist is expert in the principles, theory and technologies of molecular biology and molecu…

    Related ICD-10-CM Codes

    30 rows

    ICD-10-CM CodeDescription
    B20Human immunodeficiency virus [HIV] disease
    D68.9Coagulation defect, unspecified
    E11.9Type 2 diabetes mellitus without complications
    I20.0Unstable angina
    I21.09ST elevation (STEMI) myocardial infarction involving other coronary artery of anterior wall
    I21.3ST elevation (STEMI) myocardial infarction of unspecified site
    I22.9Subsequent ST elevation (STEMI) myocardial infarction of unspecified site
    I25.110Atherosclerotic heart disease of native coronary artery with unstable angina pectoris
    I25.119Atherosclerotic heart disease of native coronary artery with unspecified angina pectoris
    I25.810Atherosclerosis of coronary artery bypass graft(s) without angina pectoris

    Showing 1–10 of 30

    Related Payer Policy Updates

    Specialty: Hematology/Oncology1 / 3

    1 rows

    PolicyPayerEffective Date
    Epithelial Cell Cytology in Breast Cancer Risk AssessmentOscar Health2026-10-01

    Related Codes

    HCPCS-J0013-ESKETAMINE-NASAL-SPRAY-1MG

    HCPCS Level II J0013: Esketamine Nasal Spray, 1 mg

    HCPCS-J0120-INJECTION-TETRACYCLINE-250MG

    HCPCS Level II J0120: Injection, Tetracycline, up to 250 mg

    HCPCS-J0121-OMADACYCLINE-INJECTION-1MG

    HCPCS Level II J0121: Omadacycline Injection, 1 mg

    HCPCS-J0122-ERAVACYCLINE-INJECTION-1MG

    HCPCS Level II J0122: Injection, eravacycline, 1 mg

    HCPCS-J0129-ABATACEPT-INJECTION-10MG-PHYSICIAN-SUPERVISED

    HCPCS Level II J0129: Abatacept Injection, 10 mg

    HCPCS-J0130-INJECTION-ABCIXIMAB-10MG

    HCPCS Level II J0130: Injection abciximab, 10 mg

    HCPCS-J0131-INJECTION-ACETAMINOPHEN-10MG-PARENTERAL-ANALGESIC

    HCPCS Level II J0131: Injection, Acetaminophen 10 mg

    HCPCS-J0132-INJECTION-ACETYLCYSTEINE-100MG-INJECTABLE-MEDICATION

    HCPCS Level II J0132: Injection, Acetylcysteine 100 mg

    HCPCS-J0133-ACYCLOVIR-INJECTION-5MG

    HCPCS Level II J0133: Injection, Acyclovir 5 mg

    HCPCS-J0134-ACETAMINOPHEN-INJECTION-FRESENIUS-KABI-10MG

    HCPCS Level II J0134: Injection, Acetaminophen (10 mg)

    Showing 1–10 of 991

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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