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    v1.0.28
    OpenPayerBilling CodesOutpatient PPSHCPCS hcpcs-c9290-bupivacaine-liposome-injection-1mg
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    HCPCS C9290: Bupivacaine Liposome Injection, 1 mg

    HCPCS Level II code C9290 represents an injectable formulation of bupivacaine liposome, billed per 1 mg unit for use as a long-acting local anesthetic; the service is an injection typically delivered in outpatient surgical, ambulatory surgery center, or procedural clinic settings for postoperative or regional analgesia.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult undergoing a scheduled soft-tissue or surgical procedure (for example, bunionectomy, open inguinal hernia repair, or shoulder arthroscopy) requiring long-acting local analgesia at the operative site. The surgeon or anesthesiologist administers C9290 (injection, bupivacaine liposome, 1 mg) intraoperatively or immediately postoperatively as part of a multimodal analgesia plan to provide extended-duration local anesthesia and reduce opioid use. The workflow includes verification of indication and informed consent, preparation of the liposomal bupivacaine dose by a licensed clinician or pharmacy, aseptic infiltration into the surgical site or perineural space as documented in the operative or anesthesia record, monitoring in the post-anesthesia care unit for expected local anesthetic effects and potential adverse reactions, and documentation of dose administered, site of infiltration, lot number, and any immediate complications. Billing uses HCPCS Level II code C9290 with any applicable modifier(s) to reflect unusual circumstances, administrative requirements, or payer-specific rules.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    64450Injection(s), anesthetic agent; other peripheral nerve or branchPeripheral nerve block techniques may be performed with or without concurrent infiltration of C9290 for prolonged analgesia.
    20610Arthrocentesis, aspiration and/or injection; major joint or bursa (e.g., shoulder)Joint or periarticular injections may be performed in conjunction with C9290 administration for extended local pain control in surgical or procedural settings.
    99070Supplies and materials (e.g., drugs requiring additional handling)Use to bill for separately payable supplies or expensive single-use drugs associated with administration of C9290 when payer policy allows.
    99140Regional anesthesia when performed with monitored anesthesia careDocumentation of regional techniques combined with C9290 administration may use this code for reporting additional anesthesia-related services.
    01999Unlisted procedure, anesthesiaWhen an anesthesia-related service associated with novel or nonstandard use of C9290 is provided and no specific CPT exists, 01999 may be used per payer guidance.

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    23Modifier -23 (Unusual Anesthesia) is used on anesthesia service CPT codes when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia…- Use modifier -23 only on anesthesia CPT codes (00100–01999) when a procedure that normally requires no anesthesia or only local anesthesia must be performed under general anesthesia because of…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    208600000XSurgery PhysicianA general surgeon has expertise related to the diagnosis - preoperative, operative and postoperative management - and management of complications of s…
    207T00000XNeurological Surgery PhysicianA neurological surgeon provides the operative and non-operative management (i.e., prevention, diagnosis, evaluation, treatment, critical care, and reh…
    207K00000XAllergy & Immunology PhysicianAn allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Select…
    363A00000XPhysician AssistantA physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
    261QE0700XEnd-Stage Renal Disease (ESRD) Treatment Clinic/CenterAmbulatory Health Care Facilities · Clinic/Center
    207RB0002XObesity Medicine (Internal Medicine) PhysicianA physician who specializes in the treatment of obesity demonstrates competency in and a thorough understanding of the treatment of obesity and the ge…
    261QM3000XMedically Fragile Infants and Children Day CareAn entity, facility, or distinct part of a facility specially equipped and staffed to provide care for medically fragile children with varied and comp…

    Related Codes

    HCPCS-C1713-IMPLANTABLE-ANCHOR-SCREW-BONE-FIXATION

    HCPCS C1713: Anchor/Screw for Bone or Soft Tissue Fixation (Implantable)

    HCPCS-C1714-TRANSLUMINAL-DIRECTIONAL-ATHERECTOMY-CATHETER

    HCPCS C1714: Catheter, transluminal atherectomy, directional

    HCPCS-C1715-BRACHYTHERAPY-NEEDLE

    HCPCS C1715: Brachytherapy Needle

    HCPCS-C1716-BRACHYTHERAPY-GOLD-198-SOURCE

    HCPCS C1716: Brachytherapy Source, Gold-198, Per Source

    HCPCS-C1717-HDR-BRACHYTHERAPY-IRIDIUM-192-SOURCE

    HCPCS C1717: HDR Iridium-192 Brachytherapy Source, Per Source

    HCPCS-C1719-BRACHYTHERAPY-IRIDIUM-192-SOURCE-NON-STRANDED

    HCPCS C1719: Brachytherapy Source, Iridium-192, Non-Stranded

    HCPCS-C1721-IMPLANTABLE-DUAL-CHAMBER-CARDIOVERTER-DEFIBRILLATOR

    HCPCS C1721: Cardioverter-Defibrillator, Dual Chamber (Implantable)

    HCPCS-C1724-ROTATIONAL-TRANSLUMINAL-ATHERECTOMY-CATHETER

    HCPCS Level II C1724: Rotational Transluminal Atherectomy Catheter

    HCPCS-C1725-TRANSLUMINAL-ANGIOPLASTY-CATHETER-NON-LASER

    HCPCS Level II C1725: Transluminal Angioplasty Catheter, Non-Laser

    HCPCS-C1726-NON-VASCULAR-BALLOON-DILATATION-CATHETER

    HCPCS C1726: Catheter, Balloon Dilatation, Non-Vascular

    Showing 1–10 of 603

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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