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    v1.0.28
    OpenPayerBilling CodesOutpatient PPSHCPCS hcpcs-c2623-drug-coated-transluminal-angioplasty-catheter
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    HCPCS C2623: Drug-Coated Transluminal Angioplasty Catheter

    HCPCS Level II code C2623 describes a drug-coated transluminal angioplasty catheter used for percutaneous treatment of vascular stenosis; the service is a transluminal angioplasty procedure using a drug-coated catheter and is typically performed in an outpatient interventional radiology or cardiac catheterization lab setting.

    For related coverage guidance, see recent payer policy updates: Cardiac Computed Tomography (CCT)/Coronary Computed Tomographic Angiography (CCTA), Cardiovascular Disease Risk Assessment, Biomarkers for Myocardial Infarction and Chronic Heart Failure.

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    Clinical & Coding Specifications

    Clinical Context

    A typical patient is an adult with symptomatic peripheral arterial disease (PAD) of the lower extremity presenting with lifestyle-limiting claudication or critical limb ischemia (rest pain, non-healing ulcer or gangrene). The patient undergoes vascular evaluation with arterial duplex ultrasound and/or angiography documenting an atherosclerotic focal stenosis or short occlusive lesion in a femoropopliteal or infrapopliteal artery. After diagnostic angiography in an angiography suite or hybrid operating room, the interventionalist performs percutaneous transluminal angioplasty using a drug-coated balloon catheter (C2623) to reduce restenosis risk. The workflow includes vascular access (commonly common femoral artery), lesion crossing with guidewire and catheter, pre-dilation or lesion preparation as indicated, deployment of the drug-coated angioplasty catheter with inflation per manufacturer instructions, post-dilation if needed, completion angiography to confirm flow and absence of complication, hemostasis via closure device or manual compression, post-procedure monitoring in PACU or ambulatory recovery, and discharge with antiplatelet therapy and follow-up vascular clinic visit. Typical site of service is an outpatient interventional radiology or vascular surgery suite, ambulatory surgery center, or hospital outpatient department. The procedure is performed by specialists such as interventional cardiology, interventional radiology, or vascular surgery for patients with arterial atherosclerotic disease threatening limb perfusion or causing significant functional impairment.

    Related CPT Codes

    CPT CodeDescriptionRelationship to This Procedure
    93458Catheter placement in coronary artery for revascularization, including angioplasty beyond coronary arteries — Note: cardiac coronary code listed as an exampleNot typically used for peripheral procedures; listed only when coronary and peripheral interventions are performed in the same session (use appropriate peripheral CPTs instead)
    37220Revascularization, endovascular, open or percutaneous, femoral/popliteal artery, unilateral; atherectomy, with or without angioplastyMay be performed in conjunction with drug-coated balloon angioplasty if atherectomy is required for lesion preparation
    37224Revascularization, endovascular, femoral/popliteal, including angioplasty, stent placement when performed; with transluminal balloon angioplastyCommonly reported for peripheral angioplasty procedures; drug-coated balloon supply C2623 accompanies angioplasty codes when billed as device supply
    35226Bypass graft, femoropopliteal, with prosthesis; single segmentSurgical bypass alternative for severe multilevel disease when endovascular therapy is not suitable
    35476Percutaneous transluminal angioplasty, tibial/peroneal artery, unilateral, including radiological supervision and interpretationRelevant for infrapopliteal lesions where drug-coated balloons are used; often billed with device supply codes
    36147Introduction of catheter, aorta, abdominal, for diagnostic purposes or radiological supervisionDiagnostic angiography codes for arterial access and imaging that often precede therapeutic use of C2623

    Related Modifiers

    7 rows

    ModifierDescriptionWhen to Use
    22Modifier –22 (Increased Procedural Services) is used when a reported procedure is substantially more extensive than normally required. The CPT Manual and CMS state it may be appended only when the…- When to use: Append modifier -22 to a procedural CPT code when the service performed is substantially more extensive than the usual service described by that code — i.e., the procedure required…
    52Modifier ‑52 (Reduced Services) indicates that a service or procedure was partially reduced or omitted at the provider’s discretion, allowing reporting of the basic procedure number with a qualifier…- Use modifier -52 when a physician or qualified health professional electively reduces or omits part of a procedure or service (for example, performing fewer required views or omitting a portion of…
    53Modifier 53 (Discontinued Procedure) signals that a surgical or diagnostic service was begun by the physician but terminated because of extenuating circumstances that threatened the patient’s…- Use modifier -53 when a physician/qualified healthcare professional has started a surgical or diagnostic procedure (e.g., anesthesia administered, incision or scope insertion) and then discontinues…
    54Modifier ‑54 (“Surgical care only”) is appended to a CPT surgical procedure when the reporting surgeon performs the intraoperative (surgical) component but does not furnish the preoperative and/or…- Use modifier -54 when the reporting surgeon provided only the intraoperative (surgical) component of a procedure and preoperative and/or postoperative management has been or will be provided by…
    55Modifier –55 indicates the billing provider furnished only postoperative management for a procedure that has a global surgical period. According to AAPC, this modifier is appended to the same CPT…- Use modifier -55 when billing the same CPT surgical code that has a 10- or 90-day global period and you, as a provider other than the original surgeon, furnished ONLY postoperative management (no…
    56Modifier ‑56 indicates the reporting provider furnished only the preoperative management for a surgical procedure and did not perform the intraoperative or postoperative care. It is used in…- Use Modifier -56 when a provider performs only the preoperative management in a split‑care situation (one physician manages preop care while a different physician performs the intraoperative…
    62Modifier 62 indicates that two surgeons function as co‑surgeons, each performing distinct parts of the same primary surgical procedure. It is appended to the primary procedure code (and any…- Use modifier -62 when two surgeons act as co‑surgeons (both primary surgeons) on a single definitive primary procedure, each performing distinct parts of the same surgical procedure (append -62 to…

    Related Provider Taxonomies

    8 rows

    Taxonomy CodeSpecialtyNotes
    208600000XSurgery PhysicianA general surgeon has expertise related to the diagnosis - preoperative, operative and postoperative management - and management of complications of s…
    207L00000XAnesthesiology PhysicianAn anesthesiologist is trained to provide pain relief and maintenance, or restoration, of a stable condition during and immediately following an opera…
    363A00000XPhysician AssistantA physician assistant is a person who has successfully completed an accredited education program for physician assistant, is licensed by the state and…
    173000000XLegal MedicineThe specialty areas of medicine concerned with matters of, and relations with, substantive law and legal institutions; such as the conduct of medical …
    275N00000XMedicare Defined Swing Bed Hospital UnitA unit of a hospital that has a Medicare provider agreement and has been granted approval from HCFA to provide post-hospital extended care services an…
    125Q00000XOral Medicine DentistryOral Medicine is the specialty of dentistry responsible for the oral health care of medically complex patients and for the diagnosis and management of…
    171R00000XInterpreterAn Interpreter is a person who translates oral communication between two or more people. This includes translating from one language to another or in…
    133VN1005XRenal Nutrition Registered DietitianAn individual who is a Board Certified Specialist in Renal Nutrition and works directly with adult and/or pediatric patients with acute kidney injury,…

    Related Payer Policy Updates

    Specialty: Cardiology1 / 3

    10 rows

    PolicyPayerEffective Date
    Cardiac Computed Tomography (CCT)/Coronary Computed Tomographic Angiography (CCTA)univerahealthcare2026-10-15
    Cardiovascular Disease Risk AssessmentOscar Health2026-10-01
    Biomarkers for Myocardial Infarction and Chronic Heart FailureOscar Health2026-10-01
    Multiple Procedure Payment Reduction for Diagnostic Cardiovascular ProceduresBlue Cross Blue Shield - Maine2026-10-01
    Cardiovascular Disease Risk Assessmentblue cross blue shield - louisiana2026-09-15
    Cardiovascular Disease Risk AssessmentBlue Cross Blue Shield - New Mexico2026-09-04
    Computed Tomography to Detect Coronary Artery CalcificationBluecross Idaho2026-09-01
    Intracoronary Drug Delivery Balloon ProceduresBlue Cross Blue Shield - Rhode Island2026-09-01
    Cardiac Imaging Guidelinesevicore2026-09-01
    Percutaneous Left Atrial Appendage Closure Device for Stroke PreventionAmbetter Georgia2026-08-26

    Related Codes

    HCPCS-C1713-IMPLANTABLE-ANCHOR-SCREW-BONE-FIXATION

    HCPCS C1713: Anchor/Screw for Bone or Soft Tissue Fixation (Implantable)

    HCPCS-C1714-TRANSLUMINAL-DIRECTIONAL-ATHERECTOMY-CATHETER

    HCPCS C1714: Catheter, transluminal atherectomy, directional

    HCPCS-C1715-BRACHYTHERAPY-NEEDLE

    HCPCS C1715: Brachytherapy Needle

    HCPCS-C1716-BRACHYTHERAPY-GOLD-198-SOURCE

    HCPCS C1716: Brachytherapy Source, Gold-198, Per Source

    HCPCS-C1717-HDR-BRACHYTHERAPY-IRIDIUM-192-SOURCE

    HCPCS C1717: HDR Iridium-192 Brachytherapy Source, Per Source

    HCPCS-C1719-BRACHYTHERAPY-IRIDIUM-192-SOURCE-NON-STRANDED

    HCPCS C1719: Brachytherapy Source, Iridium-192, Non-Stranded

    HCPCS-C1721-IMPLANTABLE-DUAL-CHAMBER-CARDIOVERTER-DEFIBRILLATOR

    HCPCS C1721: Cardioverter-Defibrillator, Dual Chamber (Implantable)

    HCPCS-C1724-ROTATIONAL-TRANSLUMINAL-ATHERECTOMY-CATHETER

    HCPCS Level II C1724: Rotational Transluminal Atherectomy Catheter

    HCPCS-C1725-TRANSLUMINAL-ANGIOPLASTY-CATHETER-NON-LASER

    HCPCS Level II C1725: Transluminal Angioplasty Catheter, Non-Laser

    HCPCS-C1726-NON-VASCULAR-BALLOON-DILATATION-CATHETER

    HCPCS C1726: Catheter, Balloon Dilatation, Non-Vascular

    Showing 1–10 of 603

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    Frequently Asked Questions

    References

    1. 1.CPT® Codes and Descriptions. AAPC. Retrieved Aug 11, 2026.Maintains the CPT code set's official descriptions and guidelines, licensed from the American Medical Association, used as the definitional source for CPT codes on this page.
    2. 2.HCPCS Quarterly Update. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's quarterly release of HCPCS Level II codes and short/long descriptors, the source for HCPCS code definitions and update history.
    3. 3.ICD-10-CM Full Code List. Centers for Medicare & Medicaid Services (CMS). Retrieved Aug 11, 2026.CMS's complete ICD-10-CM diagnosis code list, used to cross-reference diagnosis codes associated with this procedure or service.
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